A5017711379- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Complement system in diseases
- Polyomavirus and related diseases
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Viral-associated cancers and disorders
- Sarcoma Diagnosis and Treatment
- Neurological Complications and Syndromes
- Testicular diseases and treatments
- Urologic and reproductive health conditions
- Chronic Kidney Disease and Diabetes
- Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
- Mesenchymal stem cell research
- Heme Oxygenase-1 and Carbon Monoxide
Osaka University
2014-2025
Osaka City General Hospital
2020-2023
Osaka Prefectural Medical Center
2005-2023
Tokyo Women's Medical University
2017-2020
Johns Hopkins Medicine
2016
Johns Hopkins University
2016
Sumitomo Hospital
2010-2014
Soka University
2011
Osaka Medical Center for Cancer and Cardiovascular Diseases
2010
Ikeda Municipal Hospital
2007-2008
ABSTRACT Introduction This study investigated the impact of immunosuppressive drug concentrations on microvascular inflammation (MVI) in kidney transplant recipients with negative donor‐specific antibodies (DSA) against human leukocyte antigen (HLA) and C4d deposition peritubular capillaries. Methods We analyzed data from 268 living at Department Urology, University Osaka, Japan. Patients received therapy comprising extended‐release tacrolimus, mycophenolate mofetil (MMF), and/or everolimus,...
Chemoradiation therapy (CRT) is now widely recognized as bladder-preserving for muscle-invasive bladder cancer (MIBC). However, some patients who fail CRT may miss the chance to be cured by cystectomy. Therefore, it important select with MIBC are expected have a good response CRT. Several reports indicate that excision repair cross-complementing group 1 (ERCC1) gene associated resistance cisplatin and radiation therapy. In this study, we examined correlation between ERCC1 in vitro vivo...
Renal ischemia-reperfusion (I/R) injury is unavoidable in kidney transplantation and frequently influences both short- long-term allograft survival rates. One of the major events I/R generation cytotoxic oxygen radicals. Recently, hydrogen gas has been reported to display antioxidant properties protective effects against organ dysfunction induced by various injuries. We investigated whether hydrogen-rich University Wisconsin (HRUW) solution attenuates renal cold injury.We prepared HRUW a...
Background. The chemokine receptors CCR5 and CXCR3 are expressed by T cells macrophages. We examined effects of a CCR5/CXCR3 antagonist (TAK), with particular focus on the role macrophages, in rat kidney transplant model. Methods. Dark Agouti kidneys were transplanted into Lewis rats. recipients treated daily 10 mg/kg TAK posttransplant days 0 to 14 and/or 2 cyclosporine A (CsA) 5. Graft survival, histological changes, expression chemokines macrophages studied. Results. Treatment alone...
In addition to its abundance and easy accessibility, adipose tissue yields more potent immunoregulatory stem cells (adipose tissue-derived cells, ADSCs) than does bone marrow. However, the beneficial effects of ADSCs on alloreactivity are scarcely known. This study evaluated in rat kidney transplantation analyzed underlying molecular mechanism.Dark Agouti kidneys were transplanted into Lewis rats. Autologous (2×10) injected through left renal artery donors before nephrectomy (ADSCs group)....
T-cell-mediated rejection (TCMR) remains a major cause of kidney allograft failure. The characterization T-cell repertoire in different immunological disorders has emerged recently as novel tool with significant implications. We herein sought to characterize using next generation sequencing diagnose TCMR.In this prospective study, we analyzed samples from 50 transplant recipients. collected blood and biopsy at sequential time points before post transplant. used receptor (TCR) by illumina...
Cancer cachexia is associated with a poor prognosis. This study aimed to investigate the association between sarcopenia and survival in patients metastatic hormone-sensitive prostate cancer.We retrospectively evaluated 197 diagnosed cancer our department its affiliated institution January 2008 December 2015. Sarcopenia was according sex-specific consensus definition. Castration-resistance cancer-free survival, cancer-specific overall from diagnoses were calculated using Kaplan-Meier method...
Accurate preoperative evaluation of renal function in living kidney donor candidates (LKDCs) is crucial to prevent failure after nephrectomy. We examined the performance various estimated glomerular filtration rate (eGFR) equations, including new chronic disease epidemiology collaboration (CKD-EPI) equation LKDCs.
Abstract Kidney transplantation is the most promising treatment to improve mortality and life quality in end‐stage kidney disease; however, cancer remains a leading cause of death. Several factors including immunosuppressants might be associated with gradual increase cumulative incidence after transplantation. Risk for overall cancer‐specific survival were analyzed 1973 transplant recipients from three study institutions Japan. The 5‐, 10‐, 20‐, 30‐year rates 93.3%, 88.4%, 78.0%, 63.6%...
It is important to identify prognostic and predictive markers of metastatic urothelial carcinoma (mUC) treated with immunocheckpoint inhibitors. We sought establish a marker for patients mUC pembrolizumab based on only blood test results. included 165 in the discovery cohort 103 who were validation cohort. Multivariate Cox regression analyses used analyse data. In cohort, fibrosis-4 index (hazard ratio [HR]: 2.13, 95% confidence interval [CI] 1.20-3.76, p = 0.010), albumin-bilirubin score...
Recent studies have identified T cells and natural killer (NKT) as important mediators in renal ischemia–reperfusion (I/R) injury. The recruitment of these is induced by chemotaxis factors. We investigated the effects blocking CXCR3 CCR5 an antagonist (TAK) using a rat I/R injury model. Sprague–Dawley rats were either subjected to sham operation or left occlusion for 45 min followed reperfusion contralateral nephrectomy. control TAK groups were, respectively, injected phosphate-buffered...
Abstract The frequency of malignancy is increasing in kidney transplant recipients. Posttransplant ( PTM ) a major cause long‐term graft survival inhibition. In this study, we evaluated the and prognosis at our center examined efficacy cancer screening. Between 1972 2013, 750 patients were followed‐up center. Annual physical examinations screenings performed to detect . We investigated detail two distinctive groups: screening‐detected cancers symptom‐detected cancers. Seventy‐seven...
Background The association of complement with the progression acute T cell mediated rejection (ATCMR) is not well understood. We investigated production components and expression regulatory proteins (Cregs) in T-cell using rat human renal allografts. Methods prepared allograft syngeneic graft models transplantation. Complement Cregs was assessed grafts quantitative real-time PCR (qRT-PCR) immunofluorescent staining. also administered anti-Crry anti-CD59 antibodies to model. Further, we...