A5103118561- Urological Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Pediatric Urology and Nephrology Studies
- Xenotransplantation and immune response
- Urinary and Genital Oncology Studies
- Renal Transplantation Outcomes and Treatments
- Bladder and Urothelial Cancer Treatments
- Testicular diseases and treatments
- Urologic and reproductive health conditions
- Sexual Differentiation and Disorders
- Renal and Vascular Pathologies
- Renal cell carcinoma treatment
- Pharmacological Effects and Toxicity Studies
- Congenital Anomalies and Fetal Surgery
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Vitamin D Research Studies
- Animal Genetics and Reproduction
- Sarcoma Diagnosis and Treatment
- Renal and related cancers
- Abdominal vascular conditions and treatments
- Genital Health and Disease
- Lymphoma Diagnosis and Treatment
- Advanced Glycation End Products research
- Virus-based gene therapy research
Osaka Women's and Children's Hospital
2018-2023
Osaka Medical Center for Cancer and Cardiovascular Diseases
2016-2017
Osaka University
2002-2012
National Center For Child Health and Development
2012
Inoue Hospital
2010
Massachusetts General Hospital
2004-2009
Harvard University
2004-2009
Osaka City General Hospital
2009
Osaka Prefectural Medical Center
2009
Boston University
2004
Xenograft outcomes are dictated by xenoantigen expression, for example, Gal alpha1, 3Gal (Gal), but might also depend on differing vascular responses. We investigated whether differential gene expression in kidney and cardiac xenografts correlate with development of thrombotic microangiopathy (TM) consumptive coagulation (CC). Immunosuppressed baboons underwent miniswine or hDAF pig (n = 6) heart 7), Gal-transferase gene-knockout (GalT-KO) (thymo)kidney transplantation 14). Porcine cDNA...
Renal ischemia-reperfusion (I/R) injury is unavoidable in kidney transplantation and frequently influences both short- long-term allograft survival rates. One of the major events I/R generation cytotoxic oxygen radicals. Recently, hydrogen gas has been reported to display antioxidant properties protective effects against organ dysfunction induced by various injuries. We investigated whether hydrogen-rich University Wisconsin (HRUW) solution attenuates renal cold injury.We prepared HRUW a...
Background. The chemokine receptors CCR5 and CXCR3 are expressed by T cells macrophages. We examined effects of a CCR5/CXCR3 antagonist (TAK), with particular focus on the role macrophages, in rat kidney transplant model. Methods. Dark Agouti kidneys were transplanted into Lewis rats. recipients treated daily 10 mg/kg TAK posttransplant days 0 to 14 and/or 2 cyclosporine A (CsA) 5. Graft survival, histological changes, expression chemokines macrophages studied. Results. Treatment alone...
One hundred fifty-four cases of infantile esotropia and acquired surgically treated before the age seven were followed for a minimum five years. We found 44% 60% converted to phoria with 20% having postoperative exotropia. Eight 10 years seemed be turning point from Spontaneous decrease accommodative convergence most important causative factor in relation secondary Long-term follow-up revealed residual angle deviation decreased time undercorrected resolved spontaneously. Therefore, it is...
The clinical utility of cyclosporin A (CsA) has been limited by its nephrotoxicity, which is characterized tubular atrophy, interstitial fibrosis and progressive renal impairment. Hepatocyte growth factor (HGF), plays diverse roles in the regeneration kidney following acute failure, reported to protect against salvage injury acting as a renotropic anti-fibrotic factor. Here, we investigated protective effects HGF gene therapy on CsA-induced nephrotoxicity using an electroporation-mediated...
Cyclosporine A (CsA) has improved short-term results in renal transplantation. However, its toxicities have been serious problems clinical patients undergoing long-term administration. It is necessary to develop a nonnephrotoxic immunosuppressant that allows reducing doses of CsA. The authors tested the effect new pyrazolotriazin compound, FR167653 (FR), inhibits production proinflammatory cytokines, using rat acute-rejection model (Wistar-Lewis).The first examined adverse reactions FR naive...
2011年の保険適応以降,dextranomer-hyaluronic acid copolymer(DefluxⓇ)を用いた膀胱尿管逆流(vesicoureteral reflux:VUR)に対する内視鏡的逆流防止術は本邦でも多くの施設で行われるようになったが,その長期合併症についてはあまり知られていない.今回われわれは,3歳時にDefluxⓇを用いた内視鏡的逆流防止術の既往があり,12歳時に近医にて注入部位の石灰化のため,遠位尿管結石が疑われた症例を経験した.DefluxⓇ implantの石灰化は稀ではあるが,近年欧米で報告が増えつつある.不必要な検査を回避するために,このような長期合併症を認識する必要がある.
(目的) 本研究の目的は，当センターで経験した小児急性精巣上体炎の臨床像を調査し，小児急性精巣上体炎の病因と治療を検討することである．