A5040203651- Autophagy in Disease and Therapy
- Renal Diseases and Glomerulopathies
- Biomedical Research and Pathophysiology
- Renal Transplantation Outcomes and Treatments
- Chronic Kidney Disease and Diabetes
- Lysosomal Storage Disorders Research
- Dialysis and Renal Disease Management
- Diabetes Treatment and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pancreatic function and diabetes
- Erythrocyte Function and Pathophysiology
- Cytomegalovirus and herpesvirus research
- Epigenetics and DNA Methylation
- IgG4-Related and Inflammatory Diseases
- Neurological Complications and Syndromes
- Blood Pressure and Hypertension Studies
- COVID-19 Impact on Reproduction
- Organ Donation and Transplantation
- Biomarkers in Disease Mechanisms
- Infectious Disease Case Reports and Treatments
- Amino Acid Enzymes and Metabolism
- Acute Kidney Injury Research
- COVID-19 Clinical Research Studies
- Parasites and Host Interactions
- Trypanosoma species research and implications
Osaka University
2019-2025
Japanese Red Cross Nagoya Daini Hospital
2022
Toyonaka Municipal Hospital
2021
Osaka Hospital
2015
Significance Statement Studies suggest that autophagy may be protective in kidney diseases, but understanding how the autophagic process is specifically altered each disorder important for applying it therapeutically. On basis of observation proximal tubule epithelial cells mainly regulated by insulin, authors used diabetic mouse models to investigate whether types 1 and 2 nephropathy differ status. They found distinct patterns dysregulation involved pathophysiology nephropathy, with...
Obesity is a major risk factor for end-stage kidney disease. We previously found that lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in obesity-related disease, both humans experimental animal models. However, the regulatory factors involved countering renal are largely unknown. Here, we palmitic acid strongly promoted dephosphorylation nuclear translocation of transcription EB (TFEB) by inhibiting mechanistic target rapamycin kinase complex 1 pathway Rag...
Chronic kidney disease (CKD) has reached epidemic proportions worldwide, partly due to the increasing population of elderly and obesity. Macroautophagy/autophagy counteracts CKD progression, whereas autophagy is stagnated owing lysosomal overburden during aging obesity, which promotes progression. Therefore, for preventing progression it important elucidate compensation mechanisms stagnation. We recently showed that FGF21 (fibroblast growth factor 21), a prolongevity metabolic hormone,...
Key Points The expression of MondoA was decreased in the renal tubules patients with CKD. Genetic ablation proximal inhibited autophagy and increased vulnerability to AKI through Rubicon. during recovery phase after ischemia-reperfusion aggravated kidney injury downregulation transcription factor EB-peroxisome proliferator-activated receptor- γ coactivator-1 α axis. Background Elderly individuals CKD are at a higher risk AKI. is downregulated kidneys aged or AKI; however, its roles...
ABSTRACT Introduction This study investigated the impact of immunosuppressive drug concentrations on microvascular inflammation (MVI) in kidney transplant recipients with negative donor‐specific antibodies (DSA) against human leukocyte antigen (HLA) and C4d deposition peritubular capillaries. Methods We analyzed data from 268 living at Department Urology, University Osaka, Japan. Patients received therapy comprising extended‐release tacrolimus, mycophenolate mofetil (MMF), and/or everolimus,...
Hereditary transthyretin amyloidosis (ATTRv) is a fatal disease that affects multiple organs. Up to 30% of patients with ATTRv also experience renal complications, including proteinuria and decline in eGFR. Recently, new treatments for ATTRv, tetramer stabiliser small interfering RNA (TTR siRNA) therapeutics, have emerged. However, the effectiveness these on complications remains unknown. We retrospectively collected clinical data from analysed relationship between initial age. examined...
Macroautophagy/autophagy is a lysosomal degradation system which plays protective role against kidney injury. RUBCN/Rubicon (RUN domain and cysteine-rich containing, Beclin 1-interacting protein) inhibits the fusion of autophagosomes lysosomes. However, its physiological in proximal tubular epithelial cells (PTECs) remains uncertain. In current study, we analyzed phenotype newly generated PTEC-specific rubcn-deficient (KO) mice. Additionally, investigated RUBCN lipid metabolism using...
The renoprotective effects of SLC5A2/SGLT2 (solute carrier 5 (sodium/glucose cotransporter), member 2) inhibitors have recently been demonstrated in non-diabetic chronic kidney disease (CKD), even without overt albuminuria. However, the mechanism underlying this renoprotection is largely unclear. We investigated mechanisms SLC5A2 inhibitor empagliflozin with a focus on ALB (albumin) reabsorption and macroautophagy/autophagy proximal tubules using wild-type or drug-inducible lrp2/Megalin atg5...
Accurate preoperative evaluation of renal function in living kidney donor candidates (LKDCs) is crucial to prevent failure after nephrectomy. We examined the performance various estimated glomerular filtration rate (eGFR) equations, including new chronic disease epidemiology collaboration (CKD-EPI) equation LKDCs.
We experienced a case of 36-year-old female with rapidly progressive glomerulonephritis (RPGN) due to anti-neutrophil cytoplasmic antibody (ANCA)-associated nephritis and systemic lupus erythematosus (SLE) nephritis. Chiral amino acid metabolomics revealed prominent profile d-serine in this patient. At the fulminant period RPGN, level plasma d-serine, potential biomarker CKD that reflects actual glomerular filtration ratio (GFR), was extremely high. On other hand, urinary fractional...
With the aging of society, incidence chronic kidney disease (CKD), a common cause death, has been increasing. Transcription factor EB (TFEB), master transcriptional regulator autophagy–lysosomal pathway, is regarded as promising candidate for preventing various age-related diseases. However, whether TFEB in proximal tubules plays significant role elderly CKD patients remains unknown. First, we found that nuclear localization tubular epithelial cells (PTECs) declined with age both mice and...
Abstract Background The inability of enzyme replacement therapy (ERT) to prevent progression Fabry nephropathy (FN) in the presence >1 g/day proteinuria underscores necessity identifying effective biomarkers for early diagnosis FN preceding proteinuria. Here we attempted identify detection FN. Methods Fifty-one disease (FD) patients were enrolled. Urinary mulberry bodies (uMBs) immunostained globotriaosylceramide (Gb3) and renal cell markers determine their origin. association between...
A 64-year-old man with nephrotic syndrome was admitted to another hospital where his renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) monoclonal immunoglobulin (Ig) G, subclass 1, κ light chain (IgG1κ) deposition on immunofluorescence (IF). Proliferative IgG deposits (PGNMID) suspected due IgG1κ and the absence of hematological abnormalities. However, typical PGNMID phenotype not observed by electron microscopy. Instead, an organized striated muscle-like structure in...
We aimed to investigate the clinical value of allograft biopsy performed long after renal transplantation. retrospectively evaluated 99 biopsies in recipients with transplantation vintages 10 years or longer. Mixed-effects model showed that 1-year estimated glomerular filtration rate (eGFR) slopes were significantly greater than those before [−3.13, −4.42 mL/min/1.73 m 2 /year, p = 0.01]. Renal changed treatment strategies more half patients. Improvement eGFR was pronounced 51 patients...