A5071642522- Eosinophilic Disorders and Syndromes
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Visual perception and processing mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Spatial Neglect and Hemispheric Dysfunction
- Venous Thromboembolism Diagnosis and Management
- Muscle and Compartmental Disorders
- Ophthalmology and Eye Disorders
- Lysosomal Storage Disorders Research
- RNA regulation and disease
- Neurological disorders and treatments
- Exercise and Physiological Responses
- Botulinum Toxin and Related Neurological Disorders
- SARS-CoV-2 and COVID-19 Research
- Advanced Neuroimaging Techniques and Applications
- Long-Term Effects of COVID-19
- Parkinson's Disease and Spinal Disorders
- Renal Diseases and Glomerulopathies
- Spinal Cord Injury Research
- Galectins and Cancer Biology
- Heparin-Induced Thrombocytopenia and Thrombosis
- Ergonomics and Musculoskeletal Disorders
- Intramuscular injections and effects
- Gaze Tracking and Assistive Technology
Osaka University
2022-2025
Osaka City General Hospital
2018
Osaka Prefectural Medical Center
2018
Hereditary transthyretin amyloidosis (ATTRv) is a fatal disease that affects multiple organs. Up to 30% of patients with ATTRv also experience renal complications, including proteinuria and decline in eGFR. Recently, new treatments for ATTRv, tetramer stabiliser small interfering RNA (TTR siRNA) therapeutics, have emerged. However, the effectiveness these on complications remains unknown. We retrospectively collected clinical data from analysed relationship between initial age. examined...
Background and Objective: Dementia with Lewy bodies (DLB) is frequently misdiagnosed as Alzheimer's disease (AD) due to overlapping clinical presentations. In this study, we evaluated a smartphone-based digital platform that leverages behavioral markers accurately differentiate between DLB AD. Methods: We conducted cross-sectional study on 81 participants (Healthy controls = 40, AD 21, 20), administering MMSE, noise pareidolia test (NPT) integrated eye-tracking speech inputs. Ground truth...
BACKGROUND AND OBJECTIVE: Dementia with Lewy bodies (DLB) is frequently misdiagnosed as Alzheimer’s disease (AD) due to overlapping clinical presentations. In this study, we evaluated a smartphone-based digital platform that leverages behavioral markers accurately differentiate between DLB and AD. METHODS: We conducted cross-sectional study on 81 participants (Healthy controls = 40, AD 21, 20), administering the MMSE noise pareidolia test (NPT) integrated eye-tracking speech inputs. Ground...
Abstract Pareidolias refer to visual perceptual deficits where ambiguous shapes take on meaningful appearances. In neurodegenerative diseases, pareidolias are examined via a paper-based neuropsychological tool called the noise pareidolia test. this study, we present initial findings regarding utilization of test digital format analyze variations between and testing approaches. We performed our experiments healthy controls, patients diagnosed with Alzheimer’s disease (AD), Dementia Lewy body...
Freezing of gait is one the most disturbing motor symptoms Parkinson's disease (PD). However, effective connectivity between key brain hubs that are associated with pathophysiological mechanism freezing remains elusive.
Abstract Objective This study aimed to develop a Japanese version of the New Freezing Gait Questionnaire (NFOG-Q) and investigate its validity reliability. Methods After translating NFOG-Q according standardised protocol, 56 patients with Parkinson’s disease (PD) were administered it. Additionally, MDS-UPDRS parts II III, Hoehn Yahr (H&Y) stage, number falls over 1 month evaluated. Spearman’s correlation coefficients (rho) used determine construct validity, Cronbach’s alpha (α) was...
A 53-year-old woman with severe coronavirus disease 2019 (COVID-19) pneumonia was admitted and treated intravenous unfractionated heparin for thromboprophylaxis under general anesthesia mechanical ventilation. She developed right hemiparesis after hospitalization due to a large hemorrhagic infarction. Her platelet count decreased from 243,000/μL at administration 121,000/μL. Anti-platelet factor 4-heparin antibody testing positive according latex immunoturbidimetric assay. therefore...
Abstract Pareidolias are illusionary phenomena wherein ambiguous forms appear meaningful. In clinical research, pareidolias have been studied using paper or desktop test formats to deconstruct visuo-perceptual mechanisms. Translating this work on an accessible, scalable setup such as smartphones is currently unknown. Here, we designed a smartphone-based pareidolia study visual processes affecting gaze behavior of cognitively healthy individuals standard, native front-facing camera. We...
Pareidolias refer to visual perceptual deficits where ambiguous shapes take on meaningful appearances. In neurodegenerative diseases, pareidolias are examined via a paper-based neuropsychological tool called the noise pareidolia test. this study, we present initial findings regarding utilization of test digital format analyze variations between and testing approaches. We performed our experiments healthy controls, patients diagnosed with Alzheimer's disease (AD), Dementia Lewy body (DLB)...
Recently accumulating evidence has highlighted the rare occurrence of COVID-19 vaccination-induced inflammation in central nervous system. However, precise information on immune dysregulation related to vaccination-associated autoimmunity remains elusive. Here we report a case encephalitis temporally associated with vaccination, where single-cell RNA sequencing (scRNA-seq) analysis was applied elucidate distinct signature peripheral Peripheral blood mononuclear cells (PBMCs) were analyzed...
Abstract Immune‐mediated necrotizing myopathy (IMNM) is an idiopathic inflammatory characterized by limb weakness, markedly elevated serum creatine kinase (CK), and muscle fiber necrosis without lymphocytic infiltration. Here, we present a case of IMNM that developed during pregnancy. The patient was treated immediately with systemic corticosteroids, weakness CK levels were improved adverse effects on the As there are only few reports pregnancy, clinical course treatment pregnancy discussed...