Jun Nakamura
A5027222131- Epigenetics and DNA Methylation
- Chronic Kidney Disease and Diabetes
- Biomedical Research and Pathophysiology
- Dialysis and Renal Disease Management
- Pancreatic function and diabetes
- Virus-based gene therapy research
- Fibroblast Growth Factor Research
- Acute Kidney Injury Research
- Kruppel-like factors research
- Cellular transport and secretion
- Diabetes Treatment and Management
- Diagnosis and treatment of tuberculosis
- Ferrocene Chemistry and Applications
- Diverticular Disease and Complications
- Mycobacterium research and diagnosis
- Trypanosoma species research and implications
- biodegradable polymer synthesis and properties
- Marine Biology and Environmental Chemistry
Osaka University
2022-2024
Tohoku University
1992
Chronic kidney disease (CKD) has reached epidemic proportions worldwide, partly due to the increasing population of elderly and obesity. Macroautophagy/autophagy counteracts CKD progression, whereas autophagy is stagnated owing lysosomal overburden during aging obesity, which promotes progression. Therefore, for preventing progression it important elucidate compensation mechanisms stagnation. We recently showed that FGF21 (fibroblast growth factor 21), a prolongevity metabolic hormone,...
Key Points The expression of MondoA was decreased in the renal tubules patients with CKD. Genetic ablation proximal inhibited autophagy and increased vulnerability to AKI through Rubicon. during recovery phase after ischemia-reperfusion aggravated kidney injury downregulation transcription factor EB-peroxisome proliferator-activated receptor- γ coactivator-1 α axis. Background Elderly individuals CKD are at a higher risk AKI. is downregulated kidneys aged or AKI; however, its roles...
The renoprotective effects of SLC5A2/SGLT2 (solute carrier 5 (sodium/glucose cotransporter), member 2) inhibitors have recently been demonstrated in non-diabetic chronic kidney disease (CKD), even without overt albuminuria. However, the mechanism underlying this renoprotection is largely unclear. We investigated mechanisms SLC5A2 inhibitor empagliflozin with a focus on ALB (albumin) reabsorption and macroautophagy/autophagy proximal tubules using wild-type or drug-inducible lrp2/Megalin atg5...
Abstract Inherited glycosylphosphatidylinositol (GPI) deficiency (IGD) is caused by mutations in GPI biosynthesis genes. The mechanisms of its systemic, especially neurological, symptoms are not clarified and fundamental therapy has been established. Here, we report establishment mouse models IGD PIGO as well development effective gene therapy. As the clinical manifestations systemic lifelong lasting, treated mice with adeno-associated virus for homology-independent knock-in...
Journal Article Isolation and Characteristics of Scallop Sarcoplasmic Reticulum with Calcium Transport Activity Get access Michikazu Abe, Abe *Biological Institute, Faculty Science, Tohoku UniversityAoba-yama, Aoba-ku, Sendai, Miyagi 980 Search for other works by this author on: Oxford Academic PubMed Google Scholar Yumiko Shirakata, Shirakata Dai Sato, Sato Kazuhiko Koniahi, Koniahi **Faculty Liberal Arts, Gakuin UniversitySendai, 981–31 Tsuyoshi Watanabe, Watanabe ***Department Biological...