A5047385814- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Advanced Neuroimaging Techniques and Applications
- Electron Spin Resonance Studies
- Neuroscience and Neuropharmacology Research
- MRI in cancer diagnosis
- Photoacoustic and Ultrasonic Imaging
- Biochemical effects in animals
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Liver Disease Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Solid-state spectroscopy and crystallography
- Immune cells in cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Multiple Sclerosis Research Studies
- Advanced NMR Techniques and Applications
- Dermatology and Skin Diseases
- Thermal Regulation in Medicine
- Medical Imaging Techniques and Applications
- Quantum Dots Synthesis And Properties
- Magnetism in coordination complexes
- Ultrasound and Hyperthermia Applications
- Inorganic Fluorides and Related Compounds
Osaka University
2015-2024
Ube Frontier University
2010-2024
National Institute of Information and Communications Technology
2015-2024
Iwate Medical University
2000-2024
Kindai University
2024
Osaka International University
2016-2018
Japan Science and Technology Agency
2009-2016
Kyoto Biken Laboratories (Japan)
2016
Protein Research Foundation
2016
Adult Congenital Heart Association
2015
We described perfluorocarbon encapsulated in mesoporous silica nanoparticles which enabled dual modal imaging (NIR/<sup>19</sup>F MRI) and drug delivery.
Gd3+-functionalized near-infrared emitting quantum dots were synthesized as a dual modal contrast agent for in vivofluorescence imaging and magnetic resonance imaging.
Abstract 19 F magnetic resonance imaging ( MRI) is useful for monitoring particular signals from biological samples, cells, and target tissues, because background are missing in animal bodies. Therefore, highly sensitive MRI contrast agents great demand their practical applications. However, we have faced the following challenges: 1) increasing number of fluorine atoms decreases solubility molecular probes, 2) restriction mobility attenuates signals. Herein, developed novel multifunctional...
(19)F magnetic resonance imaging (MRI) probes that can detect biological phenomena such as cell dynamics, ion concentrations, and enzymatic activity have attracted significant attention. Although perfluorocarbon (PFC) encapsulated nanoparticles are of interest in molecular owing to their high sensitivity, activatable PFC not been developed. In this study, we showed for the first time paramagnetic relaxation enhancement (PRE) effect efficiently decrease NMR/MRI signals PFCs silica...
Radiation-induced intestinal fibrosis (RIF) is a serious complication after abdominal radiotherapy for pelvic tumor or peritoneal metastasis. Herein, we show that RIF mediated by eosinophil interactions with α-smooth muscle actin-positive (α-SMA+) stromal cells. Abdominal irradiation caused especially in the submucosa (SM) of small intestine, which was associated excessive accumulation eosinophils both human and mouse. Eosinophil-deficient mice showed markedly ameliorated RIF, suggesting...
Fluorescent probes that emit in the near-infrared (NIR, 700-1,300 nm) region are suitable as optical contrast agents for vivo fluorescence imaging because of low scattering and absorption NIR light tissues. Recently, quantum dots (QDs) have become a new class fluorescent materials can be used imaging. Compared with traditional organic dyes, QDs several unique advantages such size- composition-tunable emission, high brightness, narrow emission bands, large Stokes shifts, resistance to...
Carnosic acid (CA) inhibits adipogenesis in vitro. The present study evaluated the therapeutic effects of CA ob/ob mice. experimental animals were given a standard chow diet with or without for 5 weeks. Bodyweight gain and food intake measured during this period. Magnetic resonance imaging analysis, histological examination, serum chemistry analysis intraperitoneal glucose tolerance test (IPGTT) all performed. mice fed experienced significant weight loss reduced visceral adiposity, addition...
Although pain is a common symptom of various diseases and disorders, its contribution to disease pathogenesis not well understood. Here we show using murine experimental autoimmune encephalomyelitis (EAE), model for multiple sclerosis (MS), that induces EAE relapse. Mechanistic analysis showed induction activates sensory-sympathetic signal followed by chemokine-mediated accumulation MHC class II+CD11b+ cells antigen-presentation activity at specific ventral vessels in the fifth lumbar cord...
Candida albicans infection can cause skin, vulvar, or oral pain. Despite the obvious algesic activity of C. albicans, molecular mechanisms fungal nociception remain largely unknown. Here we show that albicans-specific signaling pathway led to severe mechanical allodynia. We discovered albicans-derived β-glucan stimulated nociceptors depending on Dectin-1, and two pathways in inflammatory The major operates via Dectin-1-mediated ATP-P2X3/P2X2/3 axis through intercellular relationships between...
Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism not understood. Here we show underlying using EAE mice. Under conditions, caused severe with high-mortality. Mechanistically, autoreactive-pathogenic CD4+ T cells accumulated at specific vessels boundary area third-ventricle, thalamus, and dentate-gyrus to establish brain micro-inflammation via stress-gateway reflex. Importantly, induction by cytokine injection was sufficient fatal failure....
Sweat includes active components and metabolites, which are needed to maintain skin homeostasis. Component changes in sweat derived from atopic dermatitis (AD) have been reported. To investigate the influence of on pathogenesis AD, we performed a multifaceted assessment, including nuclear magnetic resonance spectroscopy-based metabolomic analysis, linked these features clinical AD. Distinctive properties AD quite-variation protein, anti-microbial peptides glucose concentrations. pH, sodium,...
Purpose: Magnetic resonance imaging (MRI) using contrast agents like superparamagnetic iron oxide (SPIO) is an extremely versatile technique to diagnose diseases and monitor treatment. This study tested the relative importance of particle size surface coating for optimization MRI labeling efficiency macrophages migrating remote inflammation sites. Materials methods: We four SPIO ultrasmall (USPIO), alkali-treated dextran magnetite (ATDM) with sizes 28 74 nm, carboxymethyl (CMDM) 72 nm. Mouse...
For the non-invasive visualization of phagocyte cell migration in a mouse lymph system, we developed short-wavelength infrared (SWIR) emitting multimodal probe that contains PbS/CdS quantum dots, rhodamine 6G and iron oxide nanoparticles.
Ratiometric MRI sensors consist of paramagnetic cores and pH-sensitive polymer shells. The core–shell nanostructure enables the coexistence two incompatible NMR relaxation properties in one particle. show pH sensitivity transverse relaxivity (r2), but not longitudinal (r1). Quantitative imaging is achieved by measuring r2/r1 value with a clinical 3 T scanner. As service to our authors readers, this journal provides supporting information supplied authors. Such materials are peer reviewed may...
Recent studies have demonstrated that immune cells play an important role in the pathogenesis of many neurological conditions. Immune constantly survey brain microvasculature for irregularities levels factors signal homeostasis. responses are initiated when necessary, resulting mobilisation microglial resident central nervous system (CNS) and/or infiltrating peripheral cells. However, little is known about kinetics healthy and diseased CNS, because it difficult to perform long-term...
<h3>BACKGROUND AND PURPOSE:</h3> Cognitive function can improve or decline after carotid endarterectomy. Proton MR spectroscopy be used evaluate cerebral metabolites, such as <i>N</i>-acetylaspartate, choline, and creatine, in vivo. The purpose of the present study was to determine whether postoperative changes metabolites measured by using 3T proton were associated with cognitive CEA. <h3>MATERIALS METHODS:</h3> In 100 patients undergoing CEA for ipsilateral cervical internal artery...
Proton magnetic resonance spectroscopy at 1.9 T was used to quantify dolichols, cholesterols, choline-containing phospholipids and double bonds in unsaturated acyl chains lipid extracts of four types thyroid tissue [normal (n = 27), papillary cancer 15), adenoma 13) Basedow disease 6)]. In normal the mean concentrations dolichol, cholesterol were 1.2, 3.6 2.1 micromol/g wet weight, respectively. The these lipids exhibited positive mutual correlations with patient age. increase dolichol...