A5101611559- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Malaria Research and Control
- Inflammatory mediators and NSAID effects
- Mosquito-borne diseases and control
- vaccines and immunoinformatics approaches
- Dermatology and Skin Diseases
- Bioactive Compounds and Antitumor Agents
- SARS-CoV-2 and COVID-19 Research
- Bacillus and Francisella bacterial research
- Plant chemical constituents analysis
- Bee Products Chemical Analysis
- Hippo pathway signaling and YAP/TAZ
- Neuroinflammation and Neurodegeneration Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- T-cell and B-cell Immunology
- Phytochemical compounds biological activities
- CAR-T cell therapy research
University of Massachusetts Chan Medical School
2023-2024
Izmir University
2017-2023
Dokuz Eylül University
2017-2021
Osaka University
2014-2015
Suita Municipal Hospital
2015
University of Wolverhampton
2012
Abstract Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based easier and cheaper produce do not require special storage/transportation conditions, they suitable for low-/middle-income countries. Here, we report our development studies with receptor binding domain of Delta Plus strain (RBD-DP) which caused increased hospitalizations compared other variants. First, expressed RBD-DP in Pichia pastoris yeast system upscaled it a...
Invariant Natural killer T (iNKT) cells rapidly produce copious amounts of multiple cytokines after in vivo activation, allowing for the direct detection a number directly ex vivo. However, some this approach is suboptimal. Here, we report technical variations that allow improved IL-4, IL-10, IL-13 and IL-17A Furthermore, describe an alternative stimulation iNKT vitro allows significantly produced by cells. Together, these protocols cell with increased sensitivity.
Raman spectroscopy highlights biochemical changes that are spectrally or spatially related to the presence of malaria pigment, hemozoin, inside macrophage cells, during initial stages exposure.
Zanthoxylum usambarense (Engl.) Kokwaro has traditionally been used for the treatment of malaria, upper respiratory tract infections, cough, rheumatism, tooth decay and sore gums in Kenya other African countries. Dried ground parts Z. were extracted by maceration using methanol (MeOH) at room temperature, extract was dried reconstituted 70% aq. MeOH partitioned against n ‐hexane chloroform (CHCl 3 ) to obtain MeOH, CHCl extracts. All extracts assessed cytotoxicity two breast cancer cell...
Asthma is a heterogeneous disease with neutrophilic and eosinophilic asthma as the main endotypes that are distinguished according to cells recruited airways related pathology. Eosinophilic treatment-responsive endotype, which mainly associated allergic asthma. Neutrophilic treatment-resistant affecting 5–10% of asthmatics. Although well-studied, clear understanding essential devise effective diagnosis treatment approaches for To this end, we directly compared adjuvant-induced mouse models...
The clear and unequivocal identification of immune effector functions is essential to understand responses. cytokine IL-10 a critical regulator was shown, for example, limit pathology during various lung diseases. However, the IL-10-producing cells challenging and, therefore, reporter mouse lines were developed facilitate their detection. Several such utilize GFP, including GFP (VeRT-X) strain studied here. In line with previous reports, we found that this faithfully reports on production...
Abstract Asthma is a heterogeneous disease with neutrophilic and eosinophilic asthma as the main endotypes that are distinguished according to cells recruited airways related pathology. Eosinophilic treatment-responsive endotype, which mainly associated allergic asthma. Neutrophilic treatment-resistant affecting 5-10% of asthmatics. Although well-studied, clear understanding essential devise effective diagnosis treatment approaches for To this end, we directly compared adjuvant-induced mouse...
Abstract The clear and unequivocal identification of immune effector functions is essential to understand responses. cytokine IL-10 a critical regulator was shown, for example, limit pathology during various lung diseases. However, the IL-10-producing cells challenging and, therefore, reporter mouse lines were developed facilitate their detection. Several such utilize GFP, including GFP (VeRT-X) strain studied here. In line with previous reports, we found that this faithfully reports on...