A5014635489- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Essential Oils and Antimicrobial Activity
- Machine Learning in Bioinformatics
- PARP inhibition in cancer therapy
- Immunotherapy and Immune Responses
- interferon and immune responses
- RNA modifications and cancer
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Cannabis and Cannabinoid Research
- Inflammasome and immune disorders
- Bacillus and Francisella bacterial research
Gebze Technical University
2023-2024
TÜBİTAK Marmara Research Center
2023-2024
Czech Academy of Sciences, Institute of Biotechnology
2023
Biotechnology Institute
2023
Istanbul Technical University
2017
Abstract Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based easier and cheaper produce do not require special storage/transportation conditions, they suitable for low-/middle-income countries. Here, we report our development studies with receptor binding domain of Delta Plus strain (RBD-DP) which caused increased hospitalizations compared other variants. First, expressed RBD-DP in Pichia pastoris yeast system upscaled it a...
The purpose of this study was to look into the antiviral activity a plant extract derived from roots Saussurea lappa as food supplement against SARS-CoV-2 infection.Vero E6 cells are employed in test neutralizing effect virus. For anti-viral detection, sensitive real-time cell analyzer (xCELLigence RTCA) with high repetition rate is used. A challenge experiment mice planned result vitro analysis. performed 10 adult female K18-hACE2 transgenic each group for purpose. S. Group gavaged 2 days...
Abstract Severe acute respiratory syndrome coronavirus 2 had devastating consequences for human health. Despite the introduction of several vaccines, COVID-19 continues to pose a serious health risk due emerging variants concern. DNA vaccines gained importance during pandemic their advantages such as induction both arms immune response, rapid development, stability, and safety profiles. Here, we report immunogenicity protective efficacy vaccine encoding spike protein with D614G mutation...
Abstract The aim of this study was to determine the antiviral activity cannabidiol (CBD) against SARS‐CoV‐2 infection. CBD is second most studied cannabinoid obtained from Cannabis plants. We investigated potential use CBD, which has so far proven have a positive effect on different diseases, in To test this, vivo studies were carried out using K18‐hACE2 transgenic mice. reveal therapeutic at histopathological and molecular level challenge experiments performed. designed with two groups ( n...
The function of gene body DNA methylation in alternative splicing, and its relation to disease pathogenesis is not fully elucidated. for familial Mediterranean fever (MEFV) encodes the pyrin protein contains a 998 bp CpG island, covering second exon, which differentially methylated FMF patients compared healthy controls. Our further observation increased exon 2-spliced MEFV transcript leukocytes provoked us test role splicing using inflammatory cell culture models. First, vitro triggered an...
C-Vx is a bioprotective product designed to boost the immune system. This study aimed determine antiviral activity of substance against SARS-CoV-2 infection. The effect in K18-hACE2 transgenic mice virus was investigated. For this purpose, ten were separated into experimental and control groups. Animals infected with prior administration whether has therapeutic similar that demonstrated previous human studies, at histopathological molecular level. C-Vx-treated survived challenge, whereas...