A5089650921- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Parasitic Infections and Diagnostics
- Rabies epidemiology and control
- Vector-borne infectious diseases
- Viral Infections and Vectors
- Coccidia and coccidiosis research
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Cytomegalovirus and herpesvirus research
- Bartonella species infections research
- Viral gastroenteritis research and epidemiology
- Bacteriophages and microbial interactions
- Parasitic infections in humans and animals
- Microbial infections and disease research
- Amoebic Infections and Treatments
- Vector-Borne Animal Diseases
- Hepatitis B Virus Studies
- Research on Leishmaniasis Studies
- Malaria Research and Control
- Zoonotic diseases and public health
- Parasites and Host Interactions
- Yersinia bacterium, plague, ectoparasites research
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
Ege University
2015-2025
Ege Üniversitesi Tıp Fakültesi Hastanesi
2021-2023
Bridge University
2022
Blastocystis sp. is one of the most frequently detected intestinal parasites in humans and can inhabit a wide range animals.Close contact with animals transmission factors sp.infection humans.In this study, we aimed to investigate molecular prevalence subtypes stray cats living İzmir, Turkey.The PCR targeting barcode region SSU rRNA gene was performed DNA samples isolated from feces (n:465) presence sp.PCR positive were sequenced for subtyping analysis.Among analyzed, sp.DNA 17 (3.65%) them...
Currently, some Toxoplasma gondii genotypes are being associated with serious clinical presentations. A recent report showing the Africa 1 genotype in two local congenital toxoplasmosis cases acquired Turkey formed basis of this study because atypical is most frequently detected animals and patients from sub-Saharan Africa. Since stray cats considered as linkage between wild life urban T. transmission, present aimed to isolate characterize strains circulating İzmir (Western Turkey)....
Toxoplasma gondii is a protozoon parasite that causes congenital toxoplasmosis, as well other serious clinical presentations, in immune compromised humans. Analyses of the prevalence and genotyping strains from definitive host intermediate hosts will help to understanding circulation different elucidating role genotype(s) human toxoplasmosis. Turkey has specific geographic location bridging Africa, Europe, Asia. We hypothesized T. may have been transferred these continents via migratory...
Microsporidia, which are unicellular and obligate intracellular eukaryotic pathogens, can infect many animal species humans. Cattle known to be an important source for the spread of Enterocytozoon bieneusi (E. bieneusi) humans animals. Therefore, this study aimed investigate E. in fecal samples collected from cattle environmental within a dairy farm genotype bieneusi-positive samples. For purpose, Nested PCR targeting region ribosomal DNA internal transcribed spacer (ITS) was applied...
Abstract Purpose Anaplasmosis is a tick-borne disease which caused by different Anaplasma species. Among species, A. ovis can infect sheep and goats cause ovine anaplasmosis. In this study, the prevalence of spp. was investigated in 31 breeds from regions Türkiye. Method PCR targeting MSP-4 gene blood samples (n = 366) collected Also, some positive were sequenced for species identification sub-cluster analyses. Results The molecular 43.9% (161/366). Anatolian Merino 10) Akkaraman 11) breeds,...
Toxoplasma gondii is a protozoan parasite that has widespread distribution among mammalians and birds. One of the reasons for high prevalence may be due to ingesting oocyst disseminated by stray cats' feces. In Turkey, most citizens are closely associated with cats they love pet feed them on streets. this study, we aimed determine T. DNA in feces living İzmir, Turkey order identify transmission potential humans other animals.Feces blood samples 465 were investigated presence oocysts...
Toxoplasma gondii causes congenital toxoplasmosis in newborns resulting with fetal anomalies. Determining the initiation time of infection is very important for pregnant women and current serological assays have drawbacks distinguishing recently acute toxoplasmosis. Diagnosis may be improved by using stage specific antigens assays. In present study, diagnostic value sporozoite SporoSAG, bradyzoite BAG1 proteins GRA1 protein expressed all forms parasite been evaluated ELISA sera...
Abstract Background Toxoplasma gondii is an obligate intracellular protozoan parasite that causes congenital toxoplasmosis, as well other serious clinical presentations in immune compromised humans. The has also been recently linked to behavioral diseases humans and mammalian hosts. New antigens are being evaluated develop a diagnostic kit for the diagnosis of acute infection or protective vaccine. Methods In this study, we have focused on discovery new antigenic proteins from T. genomic...
The emergence of tick-borne disease is increasing because the effects temperature rise driven by global warming. In Turkey, 19 pathogens transmitted ticks to humans and animals have been reported. Based on this, this study aimed investigate including Hepatozoon spp., Theileria Babesia Anaplasma Borrelia Bartonella spp. in tick samples (n = 110) collected from different hosts (dogs, cats, cattle, goats, sheep, turtles) molecular methods.To meet objective, were identified morphologically at...
Abstract Background Cryptosporidium spp. are obligate intracellular apicomplexan parasites transmitted to humans and other animals by contaminated water, food, or direct contact. They mainly cause gastrointestinal symptoms, although subclinical infections also common. Cats primarily infected host-adapted felis while C. parvum muris have been detected in some cases. In this study, the molecular prevalence of was investigated screening 399 fecal samples collected from stray cats using nested...
Abstract Severe acute respiratory syndrome coronavirus 2 had devastating consequences for human health. Despite the introduction of several vaccines, COVID-19 continues to pose a serious health risk due emerging variants concern. DNA vaccines gained importance during pandemic their advantages such as induction both arms immune response, rapid development, stability, and safety profiles. Here, we report immunogenicity protective efficacy vaccine encoding spike protein with D614G mutation...
Toxoplasma gondii is a protozoan parasite that can infect warm-blooded animals including humans. Vaccination studies mostly use tachyzoite specific proteins however in natural route of infection, toxoplasmosis initiates with tissue cysts (bradyzoites) or oocysts (sporozoites) and thereafter stage conversion takes place where the tachyzoites take action cause acute infection continues tachyzoites. Despite this knowledge, challenging models used vaccination prefer administration cyst forming...
Toxoplasma gondii is an obligate intracellular parasite that can infect almost all warm-blooded animals, avian species and humans. Toxoplasmosis asymptomatic in healthy individuals, whereas it may lead to death immune suppressed or deficient patients. A vaccine against T. required prevent consequences of the infection. The aim this study generate a multivalent recombinant protein gondii.49 previously discovered antigenic proteins T were evaluated by their expression level E. coli...
Bartonella spp. are vector-borne pathogens that cause zoonotic infections in humans. One of the most well-known these is cat-scratch disease caused by henselae and clarridgeiae, with cats being major reservoir for two bacteria. Izmir, Turkey home to many stray cats, but their potential role as a transmission humans has not been investigated yet. Therefore, aim this study was investigate prevalence species genetic diversity living Izmir.
Amaç: Serbest yaşayan amiplerden biri olan Acanthamoeba, başta su, toprak ve hava olmak üzere birçok çevresel örnekte tespit edilmiştir.Acanthamoeba'nın neden olduğu en önemli klinik tablolar içinde Acanthamoeba keratiti granülomatöz amibik ensefalit bulunmaktadır.Bu çalışmada örneklerde Acanthamoeba'nın varlığının daha hızlı bir şekilde saptanabilmesi için 18S rRNA gen bölgesine özgü primerler ile geliştirilen döngü aracılı izotermal amplifikasyon (LAMP) testinin hassasiyetinin belirlenmesi...
Cystic echinococcosis (CE) and alveolar (AE) caused by Echinococcus granulosus multilocularis, respectively, are important helminthic diseases worldwide as well in our country. Epidemiological studies conducted Turkey showed that the prevalence of CE is 291-585/100.000. It has also been seroprevalence AE 3.5%. For diagnosis AE, radiological (ultrasonography, computed tomography, magnetic resonance) serological methods, addition to clinical findings, being used. The definitive relies on...
Abstract Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral infection caused by virus (CCHFV). Serological screening of CCHF important and current ELISA use antigens prepared from which expensive due to requirement high bio-containment facilities. In this study, we aimed develop new recombinant ELISA. For purpose, CCHFV genome were expressed as 13 proteins in E. coli among them abundantly purified Nucleocapsid protein (rNP) Mucin-like variable domain (rMLD) used antigen...
Discovery of new Toxoplasma gondii serotyping epitopes is important due to reports showing the influence genotype on severity toxoplasmosis. In Turkey, genotypes belonging type II, III and Africa 1 lineages were mainly detected. The present study focused find out with high discriminative capacity serotype these using well characterized strains isolated from Turkey.To meet this objective, GRA6 GRA7 genes sequenced lineages, B cell inside sequences predicted by Bcepred additional docking...
Toxoplasma gondii is an obligate intracellular zoonotic parasite that can infect all warm-blooded animals, including humans. Currently, clinical findings of toxoplasmosis are being related to T. strains such as Type I genotype may cause high pathogenicity and II causes a milder presentation. We have showed in our previous the most frequent strain detected stray cats wild birds living natural life İzmir. The aim this study was assess seroprevalence immunocompromised patients, investigate...