A5038247557- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Parasitic Infections and Diagnostics
- Rabies epidemiology and control
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- vaccines and immunoinformatics approaches
- Amoebic Infections and Treatments
- Vector-borne infectious diseases
- Microbial infections and disease research
- Coccidia and coccidiosis research
- SARS-CoV-2 and COVID-19 Research
- Bartonella species infections research
- Bacteriophages and microbial interactions
- Cytomegalovirus and herpesvirus research
- Zoonotic diseases and public health
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral gastroenteritis research and epidemiology
- Vector-Borne Animal Diseases
- Parasite Biology and Host Interactions
- Tuberculosis Research and Epidemiology
- Parasites and Host Interactions
- Immunodeficiency and Autoimmune Disorders
- Yersinia bacterium, plague, ectoparasites research
- HIV Research and Treatment
Ege University
2013-2025
Ege Üniversitesi Tıp Fakültesi Hastanesi
2018-2023
Bridge University
2020
Abstract In the genome of SARS-CoV-2, 5′-terminus encodes a polyprotein, which is further cleaved into 15 non-structural proteins whereas 3′ terminus four structural and eight accessory proteins. Among these 27 proteins, present study aimed to discover likely antigenic epitopes be used for development vaccine or serodiagnostic assay using an in silico approach. For this purpose, after full analysis SARS-CoV-2 Wuhan isolate variant that are detected frequently, surface including spike,...
Blastocystis sp. is one of the most frequently detected intestinal parasites in humans and can inhabit a wide range animals.Close contact with animals transmission factors sp.infection humans.In this study, we aimed to investigate molecular prevalence subtypes stray cats living İzmir, Turkey.The PCR targeting barcode region SSU rRNA gene was performed DNA samples isolated from feces (n:465) presence sp.PCR positive were sequenced for subtyping analysis.Among analyzed, sp.DNA 17 (3.65%) them...
Microsporidia, which are unicellular and obligate intracellular eukaryotic pathogens, can infect many animal species humans. Cattle known to be an important source for the spread of Enterocytozoon bieneusi (E. bieneusi) humans animals. Therefore, this study aimed investigate E. in fecal samples collected from cattle environmental within a dairy farm genotype bieneusi-positive samples. For purpose, Nested PCR targeting region ribosomal DNA internal transcribed spacer (ITS) was applied...
Abstract Purpose Anaplasmosis is a tick-borne disease which caused by different Anaplasma species. Among species, A. ovis can infect sheep and goats cause ovine anaplasmosis. In this study, the prevalence of spp. was investigated in 31 breeds from regions Türkiye. Method PCR targeting MSP-4 gene blood samples (n = 366) collected Also, some positive were sequenced for species identification sub-cluster analyses. Results The molecular 43.9% (161/366). Anatolian Merino 10) Akkaraman 11) breeds,...
Toxoplasma gondii is a protozoon parasite that causes congenital toxoplasmosis, as well other serious clinical presentations, in immune compromised humans. Analyses of the prevalence and genotyping strains from definitive host intermediate hosts will help to understanding circulation different elucidating role genotype(s) human toxoplasmosis. Turkey has specific geographic location bridging Africa, Europe, Asia. We hypothesized T. may have been transferred these continents via migratory...
Toxoplasma gondii is a protozoan parasite that has widespread distribution among mammalians and birds. One of the reasons for high prevalence may be due to ingesting oocyst disseminated by stray cats' feces. In Turkey, most citizens are closely associated with cats they love pet feed them on streets. this study, we aimed determine T. DNA in feces living İzmir, Turkey order identify transmission potential humans other animals.Feces blood samples 465 were investigated presence oocysts...
Abstract Background Toxoplasma gondii is an obligate intracellular protozoan parasite that causes congenital toxoplasmosis, as well other serious clinical presentations in immune compromised humans. The has also been recently linked to behavioral diseases humans and mammalian hosts. New antigens are being evaluated develop a diagnostic kit for the diagnosis of acute infection or protective vaccine. Methods In this study, we have focused on discovery new antigenic proteins from T. genomic...
The emergence of tick-borne disease is increasing because the effects temperature rise driven by global warming. In Turkey, 19 pathogens transmitted ticks to humans and animals have been reported. Based on this, this study aimed investigate including Hepatozoon spp., Theileria Babesia Anaplasma Borrelia Bartonella spp. in tick samples (n = 110) collected from different hosts (dogs, cats, cattle, goats, sheep, turtles) molecular methods.To meet objective, were identified morphologically at...
Abstract Background Cryptosporidium spp. are obligate intracellular apicomplexan parasites transmitted to humans and other animals by contaminated water, food, or direct contact. They mainly cause gastrointestinal symptoms, although subclinical infections also common. Cats primarily infected host-adapted felis while C. parvum muris have been detected in some cases. In this study, the molecular prevalence of was investigated screening 399 fecal samples collected from stray cats using nested...
Toxoplasma gondii is an obligate intracellular parasite that can infect almost all warm-blooded animals, avian species and humans. Toxoplasmosis asymptomatic in healthy individuals, whereas it may lead to death immune suppressed or deficient patients. A vaccine against T. required prevent consequences of the infection. The aim this study generate a multivalent recombinant protein gondii.49 previously discovered antigenic proteins T were evaluated by their expression level E. coli...
Bartonella spp. are vector-borne pathogens that cause zoonotic infections in humans. One of the most well-known these is cat-scratch disease caused by henselae and clarridgeiae, with cats being major reservoir for two bacteria. Izmir, Turkey home to many stray cats, but their potential role as a transmission humans has not been investigated yet. Therefore, aim this study was investigate prevalence species genetic diversity living Izmir.
Amaç: Serbest yaşayan amiplerden biri olan Acanthamoeba, başta su, toprak ve hava olmak üzere birçok çevresel örnekte tespit edilmiştir.Acanthamoeba'nın neden olduğu en önemli klinik tablolar içinde Acanthamoeba keratiti granülomatöz amibik ensefalit bulunmaktadır.Bu çalışmada örneklerde Acanthamoeba'nın varlığının daha hızlı bir şekilde saptanabilmesi için 18S rRNA gen bölgesine özgü primerler ile geliştirilen döngü aracılı izotermal amplifikasyon (LAMP) testinin hassasiyetinin belirlenmesi...
Abstract Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral infection caused by virus (CCHFV). Serological screening of CCHF important and current ELISA use antigens prepared from which expensive due to requirement high bio-containment facilities. In this study, we aimed develop new recombinant ELISA. For purpose, CCHFV genome were expressed as 13 proteins in E. coli among them abundantly purified Nucleocapsid protein (rNP) Mucin-like variable domain (rMLD) used antigen...
Discovery of new Toxoplasma gondii serotyping epitopes is important due to reports showing the influence genotype on severity toxoplasmosis. In Turkey, genotypes belonging type II, III and Africa 1 lineages were mainly detected. The present study focused find out with high discriminative capacity serotype these using well characterized strains isolated from Turkey.To meet this objective, GRA6 GRA7 genes sequenced lineages, B cell inside sequences predicted by Bcepred additional docking...
Toxoplasma gondii is an obligate intracellular zoonotic parasite that can infect all warm-blooded animals, including humans. Currently, clinical findings of toxoplasmosis are being related to T. strains such as Type I genotype may cause high pathogenicity and II causes a milder presentation. We have showed in our previous the most frequent strain detected stray cats wild birds living natural life İzmir. The aim this study was assess seroprevalence immunocompromised patients, investigate...
Abstract Severe acute respiratory syndrome coronavirus 2 had devastating consequences for human health. Despite the introduction of several vaccines, COVID-19 continues to pose a serious health risk due emerging variants concern. DNA vaccines gained importance during pandemic their advantages such as induction both arms immune response, rapid development, stability, and safety profiles. Here, we report immunogenicity protective efficacy vaccine encoding spike protein with D614G mutation...