Pelin Sağlam-Metiner

ORCID: 0000-0002-5726-1928
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About
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Research Areas
  • 3D Printing in Biomedical Research
  • Tissue Engineering and Regenerative Medicine
  • Cancer Cells and Metastasis
  • Pluripotent Stem Cells Research
  • RNA Interference and Gene Delivery
  • Bone Tissue Engineering Materials
  • Monoclonal and Polyclonal Antibodies Research
  • Osteoarthritis Treatment and Mechanisms
  • Electrospun Nanofibers in Biomedical Applications
  • Advanced biosensing and bioanalysis techniques
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Viral Infectious Diseases and Gene Expression in Insects
  • Essential Oils and Antimicrobial Activity
  • Virus-based gene therapy research
  • Inhalation and Respiratory Drug Delivery
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Bee Products Chemical Analysis
  • Knee injuries and reconstruction techniques
  • Immunotherapy and Immune Responses
  • Mathematical Biology Tumor Growth
  • Nanofabrication and Lithography Techniques
  • Toxoplasma gondii Research Studies
  • Periodontal Regeneration and Treatments
  • Advancements in Transdermal Drug Delivery
  • Extracellular vesicles in disease

University Medical Center Utrecht
2023-2024

Utrecht University
2023-2024

Ege University
2017-2024

The bioengineerined and whole matured human brain organoids stand as highly valuable three-dimensional in vitro brain-mimetic models to recapitulate vivo development, neurodevelopmental neurodegenerative diseases. Various instructive signals affecting multiple biological processes including morphogenesis, developmental stages, cell fate transitions, migration, stem function immune responses have been employed for generation of physiologically functional cerebral organoids. However, the...

10.1038/s42003-023-04547-1 article EN cc-by Communications Biology 2023-02-14

Abstract BACKGROUND Propolis exhibits therapeutic properties due to the presence of phenolic acids, esters, and flavonoids. The scope this study was develop a nano‐vesicular formulation establish three‐dimensional (3D) spheroid model in which lung cancer is recapitulated. RESULTS Niosome vesicles doped with galangin‐rich propolis extract were synthesized by ether injection method using cholesterol : surfactant mass ratio 1 3 at 40 °C for h. Formulated niosomes administered 3D cytotoxicity...

10.1002/jsfa.10400 article EN Journal of the Science of Food and Agriculture 2020-04-02

Abstract Background and Objective The updated World Health Organization (WHO) air quality guideline recommends an annual mean concentration of fine particulate matter (PM2.5) not exceeding 5 or 15 μg/m 3 in the short‐term (24 h) for no more than 3–4 days annually. However, 90% global population is currently exposed to daily concentrations surpassing these limits, especially during extreme weather conditions due transboundary dust transport influenced by climate change. Herein, effect...

10.1111/all.16179 article EN cc-by-nc Allergy 2024-06-13

Astaxanthin is one of the most attractive carotenoid in cosmetic, food, pharmaceutical, and aquaculture industries due to its strong bioactive properties. Among various sources, several algae species are considered as rich sources astaxanthin. Downstream processing involves majority total costs. Thus, elimination high energy involved steps imperative achieve cost-effective scale industry. This study aimed determine operation conditions for astaxanthin extraction from wet Haematococcus...

10.1080/10826068.2022.2116455 article EN Preparative Biochemistry & Biotechnology 2022-09-01

Abstract The temporomandibular joint (TMJ) is commonly affected during fundamental oral activities, reducing the quality of life. Herein, we synthesized a heparin‐conjugated poloxamer hydrogel (HEP) as thermo‐responsive injectable for treatment TMJ disorders. While gelation temperature HEP (25% [w/v]) was 29.8–30.0°C, there slight difference between loss and storage modulus. decreased friction TMJ, thus requires less energy load‐bearing jaw movement in comparison to POL. Moreover,...

10.1002/app.52736 article EN Journal of Applied Polymer Science 2022-06-09

Resistance to currently available antifungal agents raises the need develop alternative remedies. Candida albicans is most common opportunistic pathogenic fungus of humans, colonizing in genital and intestinal mucosa, skin, oral-nasal cavity reducing quality life. Herein, essential oil from grapefruit (Citrus paradise) peels was obtained by hydrodistillation, remaining plant material sequentially subjected supercritical carbon dioxide (SC-CO2) extraction determine conditions for maximizing...

10.1021/acsomega.2c04189 article EN cc-by-nc-nd ACS Omega 2022-10-13
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