A5038925906- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Additive Manufacturing and 3D Printing Technologies
- Orthopaedic implants and arthroplasty
- biodegradable polymer synthesis and properties
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing Materials and Processes
- Magnesium Alloys: Properties and Applications
- Titanium Alloys Microstructure and Properties
- Dental materials and restorations
- Osteoarthritis Treatment and Mechanisms
- Graphene and Nanomaterials Applications
- Aluminum Alloys Composites Properties
- Innovative Microfluidic and Catalytic Techniques Innovation
- Silk-based biomaterials and applications
- Dental Implant Techniques and Outcomes
- Surface Modification and Superhydrophobicity
- Tendon Structure and Treatment
- Cellular Mechanics and Interactions
- Shoulder Injury and Treatment
- Advanced Polymer Synthesis and Characterization
- Dental Radiography and Imaging
- High Entropy Alloys Studies
- Endodontics and Root Canal Treatments
Warsaw University of Technology
2016-2025
Faculty (United Kingdom)
2019-2025
Materials Science & Engineering
2016-2025
Max Planck Institute for Extraterrestrial Physics
2023
Medical University of Białystok
2023
Institute of High Pressure Physics
2023
Warsaw University of Life Sciences
2023
Polish Academy of Sciences
2023
Gdańsk University of Technology
2021
University of Warsaw
2016-2019
We present a new strategy for the fabrication of artificial skeletal muscle tissue with functional morphologies based on an innovative 3D bioprinting approach. The methodology is microfluidic printing head coupled to co-axial needle extruder high-resolution hydrogel fibers laden precursor cells (C2C12). To promote myogenic differentiation, we formulated tailored bioink photocurable semi-synthetic biopolymer (PEG-Fibrinogen) encapsulating into constructs composed aligned fibers. After 3-5...
Abstract For many years, the solid metals and their alloys have been widely used for fabrication of implants replacing hard human tissues or functions. To improve fixation to surrounding bone tissues, materials with porous structures introduced. By tissue ingrowing into a structure metallic implant, bonding between implant has obtained. Substantial pore interconnectivity, in implants, allows extensive body fluid transport through implant. This can provoke ingrowth, consequently, leading...
Additive Manufacturing (AM) methods are generally used to produce an early sample or near net-shape elements based on three-dimensional geometrical modules. To date, publications AM of metal implants have mainly focused knee and hip replacements bone scaffolds for tissue engineering. The direct fabrication metallic can be achieved by methods, such as Selective Laser Melting (SLM) Electron Beam (EBM). This work compares the SLM EBM in titanium analyzing microstructure, mechanical properties...
In this work we demonstrate how to print 3D biomimetic hydrogel scaffolds for cartilage tissue engineering with high cell density (>10(7) cells ml(-1)), viability (85 ÷ 90%) and printing resolution (≈100 μm) through a two coaxial-needles system. The were composed of modified biopolymers present in the extracellular matrix (ECM) cartilage, namely gelatin methacrylamide (GelMA), chondroitin sulfate amino ethyl methacrylate (CS-AEMA) hyaluronic acid (HAMA). polymers used prepare three...
Abstract Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth‐supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal generally by using membrane. The main role of these membranes to establish mechanical barrier that prevents the apical migration gingival epithelium and hence allowing growth ligament bone selectively repopulate root surface. Currently available have limited bioactivity potential. To address...
Abstract Small fractures in bone tissue can heal by themselves, but case of larger defects current therapies are not completely successful due to several drawbacks. A possible strategy relies on the combination additive manufactured polymeric scaffolds and human mesenchymal stromal cells (hMSCs). The architecture is characterized a structural gradient. Long bones display gradient radial direction, while flat axial direction. Such presents variation density from cancellous cortical bone....
Osteochondral (OC) tissue is a biphasic material comprised of articular cartilage integrated atop subchondral bone. Damage to this highly problematic, owing its intrinsic inability regenerate functional in response trauma or disease. Further, the function largely conferred by compartmentalized zonal microstructure and composition. Current clinical treatments fail new that recapitulates structure. Consequently, regenerated often lacks long-term stability. To address growing problem, we...
Next generation engineered tissue constructs with complex and ordered architectures aim to better mimic the native structures, largely due advances in three-dimensional (3D) bioprinting techniques. Extrusion has drawn tremendous attention its widespread availability, cost-effectiveness, simplicity, facile rapid processing. However, poor printing resolution low speed have limited fidelity clinical implementation. To circumvent downsides associated extrusion printing, microfluidic technologies...
Gelatin methacrylate (GelMA) is an inexpensive, photocrosslinkable, cell-responsive hydrogel which has drawn attention for a wide range of tissue engineering applications. The potential GelMA scaffolds was demonstrated to be tunable different (TE) applications through modifying the polymer concentration, methacrylation degree, or UV light intensity. Despite promising results hydrogels in engineering, influence concentration bone (BTE) not established yet. Thus, this study, we have effect on...
Abstract One of the biggest challenges in peripheral nerve tissue engineering is to create an artificial graft that could mimic extracellular matrix (ECM) and assist regeneration. Bio‐composite nanofibrous scaffolds made from synthetic natural polymeric blends provide suitable substrate for it can be used as guides eliminating need autologous grafts. Nanotopography or orientation fibers within greatly influences cell morphology outgrowth, alignment ensures better contact guidance cells. In...
Fiber-based approaches hold great promise for tendon tissue engineering enabling the possibility of manufacturing aligned hydrogel filaments that can guide collagen fiber orientation, thereby providing a biomimetic micro-environment cell attachment, migration, and proliferation. In this study, 3D system composed cell-laden, highly yarns is designed obtained via wet spinning in order to reproduce morphology structure fascicles. A bioink alginate gelatin methacryloyl (GelMA) optimized loaded...
In this study, we present an innovative strategy to reinforce 3D-printed hydrogel constructs for cartilage tissue engineering by formulating composite bioinks containing alginate and short sub-micron polylactide (PLA) fibers. We demonstrate that Young's modulus obtained pristine (6.9 ± 1.7 kPa) can be increased threefold (up 25.1 3.8 with the addition of PLA Furthermore, assess performance such materials in engineering, loaded human chondrocytes cultured vitro bioprinted up 14 days....
One promising strategy to reconstruct osteochondral defects relies on 3D bioprinted three-zonal structures comprised of hyaline cartilage, calcified and subchondral bone. So far, several studies have pursued the regeneration either cartilage or bone in vitro while-despite its key role region-only few them targeted layer. In this work, we present a biomimetic hydrogel scaffold containing β-tricalcium phosphate (TCP) for engineering through co-axial needle system implemented extrusion-based...
Abstract Tailoring the morphology of macroporous structures remains one biggest challenges in material synthesis. Herein, we present an innovative approach for fabrication custom materials which pore size varies throughout structure by up to order magnitude. We employed a valve‐based flow‐focusing junction (vFF) orifice can be adjusted real‐time (within tens milliseconds) generate foams with on‐line controlled bubble size. used fabricate layered and smoothly graded porous varying range...
Nowadays, post-surgical or post-accidental bone loss can be substituted by custom-made scaffolds fabricated additive manufacturing (AM) methods from metallic powders. However, the partially melted powder particles must removed in a post-process chemical treatment. The aim of this study was to investigate effect polishing with various acid baths on novel scaffolds' morphology, porosity and mechanical properties. In first stage, Magics software (Materialise NV, Leuven, Belgium) used design...