A5041527275- Sperm and Testicular Function
- Testicular diseases and treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer, Lipids, and Metabolism
- Spinal Cord Injury Research
- Aortic Disease and Treatment Approaches
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Meningioma and schwannoma management
- Diamond and Carbon-based Materials Research
- Advanced biosensing and bioanalysis techniques
- Nerve injury and regeneration
- Cardiac Imaging and Diagnostics
- Veterinary medicine and infectious diseases
- Mesenchymal stem cell research
- Ginseng Biological Effects and Applications
- Wound Healing and Treatments
- Neurological Disease Mechanisms and Treatments
- Hormonal Regulation and Hypertension
- Abdominal Surgery and Complications
- Intestinal and Peritoneal Adhesions
- Cerebrospinal fluid and hydrocephalus
- Pancreatic function and diabetes
- Bioactive natural compounds
- Lipid metabolism and biosynthesis
Ege University
2019-2024
Ege Üniversitesi Tıp Fakültesi Hastanesi
2021
Doxorubicin (DOX) is an anthracycline derivative antibiotic that still frequently used in the treatment of solid tumors and hematological malignancies. The clinical use DOX largely restricted due to acute chronic renal, cardiac, hematological, testicular toxicities. Previous studies have indicated oxidative stress, lipid peroxidation, apoptosis germ cells are main factors DOX-induced toxicity, but entire molecular mechanisms responsible for damage not yet fully understood. Fluvastatin a...
BACKGROUND: Spinal cord injury is a devastating trauma that leaves survivors at risk for several medical complications throughout their lives.Lercanidipine, third-generation calcium channel blocker, possesses anti-apoptotic, anti-inflammatory, and antioxidative properties.This study aimed to evaluate the neuroprotective effects of lercanidipine in an experimental spinal model. METHODS:Twenty-one Wistar rats were randomly assigned three groups.Group 1 (G1) underwent laminectomy.Group 2 (G2)...
Doxorubicin (DOXO) is a cytostatic agent used in the chemotherapy protocol of several cancers for more than 40 years, but usage this drug cancer treatment has been limited due to severe renal and cardiac tissue toxicities that may result death patients. Fluvastatin (FV) fully synthetic hydroxymethyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor as cholesterol-lowering patients with hypercholesterolemia. Previous studies revealed FV also exhibits antioxidant, anti-inflammatory, antitumor...
Diabetic neuropathy (DN) is the most common degenerative complication associated with Diabetes Mellitus. Despite widespread awareness about DN, only effective treatments are blood glucose control and pain management. The aim of current study was to determine effect intramuscular adipose-derived mesenchymal stem cell (AMSC) transplantation on sciatic nerves in DN using EMG histological analyses. A total 27 mice were randomly divided into three groups: group, group AMSC group. In EMG, CMAP...
Losartan, an antihypertensive drug, is highly preferred in patients with diabetes mellitus (DM) and hypertension because of its retarding effect on diabetic nephropathy. In this study, we investigated the potential therapeutic different doses losartan hepatic damage a streptozotocin (STZ, 50 mg/kg)-induced DM model rats.In five groups were formed: control, DM, low-dose (5 mg/kg), mid-dose (20 high-dose (80 mg/kg). Liver tissues experimental evaluated immunohistochemically for TUNEL, iNOS,...
AIM:To investigate the effects of fluorescein-sodium on neural tissues. MATERIAL and METHODS:Twenty-one Wistar rats were randomly divided into three experimental groups: control (group 1) groups with different doses (groups 2 3).In group, craniectomy following durotomy was performed help a loupe microscope, dry sponge overlayed to brain tissue.In study groups, open dura covered soaked 0.02 mg 2) 0.2 3) fluorescein sodium craniectomy.Three weeks postoperatively, sacrificed for histopathologic...
Streptozotocin (STZ) is used as a diabetes-inducing agent in experimental animal studies. However, it known that STZ-induced diabetic animals show significant increases oxidative stress parameters and neurodegeneration besides their blood glucose level. In this study, the acute subacute toxic effects of STZ on liver, sciatic nerve, brain tissues were investigated vivo rat model. Sprague-Dawley rats divided into two groups; while 50 mg/kg was administered ip to group, only saline control...
Adjuvants are components of vaccines that boost the intensity, duration, and breadth immune response. Insight into mechanisms responsible for immunotoxicity both local systemic adverse reactions following use adjuvants has been gained through research over past twenty years. In present study, single repeated-dose toxicity tolerance newly developed Water-in-Oil (W/O) Water-in-Oil-in-Water (W/O/W) Emulsion (Coralvac RZ 528, Coralvac 506, AT 318, 318 SIS 252) by Coral Biotechnology Industry...
Abstract Background: Diabetes mellitus (DM) is common metabolic disease that poses a major risk to public health and fertility. Previous studies indicate DM may cause male infertility by triggering oxidative stress germ cell apoptosis in the testis. Present study aimed investigate possible antiapoptotic effect of losartan against DM-induced testicular apoptosis. Methods Results: Expreimental model was induced intraperitoneal injection streptozocin (STZ, 55 mg/kg) 28 rats, which were then...
Amaç: Çalışmanın amacı pneumoperitoneumun over dokusu üzerinde oluşturduğu olası iskemi reperfüzyon hasarının gösterilmesi ve D vitamininin bu hasar üzerindeki etkilerinin araştırılmasıdır. Gereç Yöntem: Çalışmamızda her biri 7 denekten oluşan 3 grup şeklinde Sprague Dawley cinsi dişi sıçanlar kullanılmıştır. Pneumoperitoneum sağlandıktan 60 dakika sonra desuflasyon gerçekleşt r lm ş 30 boyunca intraabdominal basınç normalize edilmiştir eperfüzyon periyodunu takiben overler çıkarılmış hasarı...