A5025808061- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Immunotherapy and Immune Responses
- Poxvirus research and outbreaks
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- vaccines and immunoinformatics approaches
- SARS-CoV-2 detection and testing
- Bacillus and Francisella bacterial research
- Influenza Virus Research Studies
Gedik University
2021-2023
İstanbul Pendik Veteriner Kontrol Enstitüsü
2021-2022
Sakarya University
2022
TÜBİTAK Marmara Research Center
2021
Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes development immunogenicity VLP vaccine incorporates four structural proteins SARS-CoV-2.VLPs were generated in transiently transfected HEK293 cells, purified by multimodal chromatography, characterized tunable-resistive pulse sensing, AFM, SEM, TEM. Immunoblotting studies verified protein identities VLPs. Cellular immune responses...
Abstract Recombinant protein-based SARS-CoV-2 vaccines are needed to fill the vaccine equity gap. Because protein-subunit based easier and cheaper produce do not require special storage/transportation conditions, they suitable for low-/middle-income countries. Here, we report our development studies with receptor binding domain of Delta Plus strain (RBD-DP) which caused increased hospitalizations compared other variants. First, expressed RBD-DP in Pichia pastoris yeast system upscaled it a...
Abstract Severe acute respiratory syndrome coronavirus 2 had devastating consequences for human health. Despite the introduction of several vaccines, COVID-19 continues to pose a serious health risk due emerging variants concern. DNA vaccines gained importance during pandemic their advantages such as induction both arms immune response, rapid development, stability, and safety profiles. Here, we report immunogenicity protective efficacy vaccine encoding spike protein with D614G mutation...
Background: People spent more time at home as part of the precaution taken after COVID-19 pandemic. In this stage, human beings began to own pets and spend with them. One most significant questions during period was whether could be transmitted pets. Beta coronavirus already known in veterinary field cause diseases different pathogenicity many animal species. Over time, research has shown that disease can wild animals. Many studies have equines infected disease. This study serologically...
The coronavirus disease 2019 (COVID-19) turned into a pandemic shortly after emerging in December 2019, the city of Wuhan, China. In this study, it was aimed to investigate presence severe acute respiratory system coronavirus-2 (SARS-CoV-2) RNA various clinical samples and scattering profile virus variation anti-SARS-CoV-2 IgG neutralizing antibody levels over time infected patients during period COVID-19 disease. study included from community (CCP) (n= 47) (May-June 2020) healthcare workers...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 and rapidly spread throughout the world. After susceptibility of various animals to SARS-CoV-2 infection was reported, prevalence COVID-19 pet their role virus transmission became a source concern. Seroprevalence has been reported from parts world date. In this study, 206 serum samples household dogs cats were obtained diagnostic laboratory Istanbul. Ninety-nine collected during second wave (November December...
Background Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes development immunogenicity VLP vaccine incorporates 4 structural proteins SARS-CoV-2. Methods VLPs were generated in transiently transfected HEK293 cells, purified by multimodal chromatography characterized tunable resistive pulse sensing, AFM, SEM, TEM. Immunoblotting studies verified protein identities VLPs. Cellular immune...
Background Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes development immunogenicity VLP vaccine incorporates 4 structural proteins SARS-CoV-2. Methods VLPs were generated in transiently transfected HEK293 cells, purified by multimodal chromatography characterized tunable resistive pulse sensing, AFM, SEM, TEM. Immunoblotting studies verified protein identities VLPs. Cellular immune...