A5012612442- SARS-CoV-2 and COVID-19 Research
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Viral gastroenteritis research and epidemiology
- Immune cells in cancer
- Synthesis and biological activity
- COVID-19 Clinical Research Studies
- Characterization and Applications of Magnetic Nanoparticles
- Advanced MRI Techniques and Applications
- Atherosclerosis and Cardiovascular Diseases
- interferon and immune responses
- HIV-related health complications and treatments
- Research on Leishmaniasis Studies
- Cannabis and Cannabinoid Research
- Quinazolinone synthesis and applications
- Cytokine Signaling Pathways and Interactions
- Microfluidic and Bio-sensing Technologies
- Parasites and Host Interactions
- Inflammatory mediators and NSAID effects
- Extracellular vesicles in disease
- Peptidase Inhibition and Analysis
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Trypanosoma species research and implications
- Ultrasound and Hyperthermia Applications
Bilkent University
2015-2024
Nanyang Technological University
2016
Resonance Research (United States)
2015
Abstract Chemoresistance is a major obstacle in triple negative breast cancer (TNBC), the most aggressive subtype. Here we identify hypoxia-induced ECM re-modeler, lysyl oxidase (LOX) as key inducer of chemoresistance by developing chemoresistant TNBC tumors vivo and characterizing their transcriptomes RNA-sequencing. Inhibiting LOX reduces collagen cross-linking fibronectin assembly, increases drug penetration, downregulates ITGA5/FN1 expression, resulting inhibition FAK/Src signaling,...
A bioactive lipokine promotes metabolic resilience of organelles and limits the progression atherosclerosis.
Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes development immunogenicity VLP vaccine incorporates four structural proteins SARS-CoV-2.VLPs were generated in transiently transfected HEK293 cells, purified by multimodal chromatography, characterized tunable-resistive pulse sensing, AFM, SEM, TEM. Immunoblotting studies verified protein identities VLPs. Cellular immune responses...
Immunomodulatory commensal bacteria modify host immunity through delivery of regulatory microbial-derived products to cells. Extracellular membrane vesicles (MVs) secreted from symbiont commensals represent one such transport mechanism. How MVs exert their anti-inflammatory effects or whether tolerance-inducing potential can be used for therapeutic purposes remains poorly defined. In this study, we show that isolated the human lactic acid Pediococcus pentosaceus suppressed Ag-specific...
Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate (OPCA) on a preclinical model MS. First, OPCA was synthesized semisynthetically and characterized. Then, mice with MOG35–55-induced experimental autoimmune/allergic encephalomyelitis (EAE) were given along reference drug (FTY720). Biochemical, cellular, molecular analyses performed in serum brain tissues to...
We reported highly crystalline, monodisperse and low-magnetization magnetite nanocubes as potential dual-modal contrast agents exhibiting high longitudinal (<italic>r</italic><sub>1</sub> ∼ 5.23 mM<sup>−1</sup> s<sup>−1</sup>) transverse (<italic>r</italic><sub>2</sub> 89.68 relaxivities.
Purpose To introduce a temperature sensor implant (TSI) that mimics an active implantable medical device (AIMD) for animal testing of MRI heating. Computer simulations and phantom experiments poorly represent potential increases. Animal could be better model, but heating conducted immediately after the surgery suffer from alterations thermoregulatory tissue properties during acute conditions. Therefore, aim this study was to AIMD capable measuring electrode implantation without any further...
Immune-mediated inflammation must be down-regulated to facilitate tissue remodeling during homeostatic restoration of an inflammatory response. Uncontrolled or over-exuberant immune activation can cause autoimmune diseases, as well destruction. A151, the archetypal example a chemically synthesized suppressive oligodeoxynucleotide (ODN) based on repetitive telomere-derived TTAGGG sequences, was shown successfully down-regulate variety responses. However, degree, duration and breadth...
Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and resistant to both conventional targeted chemotherapy. Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown decrease the incidence mortality of different types cancers. Here, we investigated cellular bioactivities series triazolothiadiazine derivatives on HCC, which previously reported as potent analgesic/anti-inflammatory compounds. From initially tested 32 NSAID derivatives, 3 compounds were selected...
In this work, we report Mn-Fe heterodoped ZnSe tetrapod nanocrystals (NCs) synthesized to synergistically enhance contrast in both T1- and T2-weighted magnetic resonance imaging (MRI). The proposed NCs were prepared using a customized heteroarchitecture such that the manganese (Mn) is confined core iron (Fe) branches of tetrapods. elemental composition profile these studied X-ray photoelectron spectroscopy, energy-dispersive inductively coupled plasma mass spectroscopy. Photoluminescence...
Leishmania parasites harbor a unique network of circular DNA known as kinetoplast (kDNA). The role kDNA in leishmania infections is poorly understood. Herein, we show that delivery to the cytosol major infected THP-1 macrophages provoked increased parasite loads when compared untreated cells, hinting at involvement cytosolic sensors facilitating evasion from immune system. Parasite proliferation was significantly hindered cGAS- STING- and TBK-1 knockout wild type cells. Nanostring nCounter...
Non-small cell lung cancer (NSCLC) constitutes 87% of all cases as a late diagnosed tumor with highest mortality rate. We previously reported cannabinoid 1 (CB1) receptor-mediated apoptotic effect CB1 agonist Arachidonoylcyclopropylamide (ACPA) and generated novel polycaprolactone-based ACPA nanoparticular system (NanoACPA) acting on NSCLC through PI3K/Akt JNK pathways in vitro (PCT/TR2020/050618). Here, we hypothesized that NanoACPA technology platform selectively targeting receptor might...
Background Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes development immunogenicity VLP vaccine incorporates 4 structural proteins SARS-CoV-2. Methods VLPs were generated in transiently transfected HEK293 cells, purified by multimodal chromatography characterized tunable resistive pulse sensing, AFM, SEM, TEM. Immunoblotting studies verified protein identities VLPs. Cellular immune...
Background Vaccines that incorporate multiple SARS-CoV-2 antigens can further broaden the breadth of virus-specific cellular and humoral immunity. This study describes development immunogenicity VLP vaccine incorporates 4 structural proteins SARS-CoV-2. Methods VLPs were generated in transiently transfected HEK293 cells, purified by multimodal chromatography characterized tunable resistive pulse sensing, AFM, SEM, TEM. Immunoblotting studies verified protein identities VLPs. Cellular immune...
The purpose of this work is to synthesize Mn-Fe heterodoped ZnSe tetrapod nanocrystals (NCs) as dual-mode MRI contrast agent offer synergetic beneficial over the single tracer. Also, in vivo feasibility NCs a has been studied.
Abstract Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, and resistant to both conventional targeted chemotherapy. (NSAIDs) Recently, nonsteroidal anti-inflammatory drugs have been shown decrease the incidence mortality of different types cancers. Here, we investigated cellular bioactivities series triazolothiadiazine derivatives on HCC, which previously reported as potent analgesic/anti-inflammatory compounds. From initially tested 32 NSAID derivatives, 3 compounds were...