A5015437021- Synthesis and biological activity
- Computational Drug Discovery Methods
- Enzyme function and inhibition
- Cholinesterase and Neurodegenerative Diseases
- Natural product bioactivities and synthesis
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Free Radicals and Antioxidants
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Organic Chemistry Cycloaddition Reactions
- Essential Oils and Antimicrobial Activity
- Seaweed-derived Bioactive Compounds
- Metal complexes synthesis and properties
- Plant biochemistry and biosynthesis
- Cancer Mechanisms and Therapy
- Synthesis and Catalytic Reactions
- Synthesis of Tetrazole Derivatives
- Sesquiterpenes and Asteraceae Studies
- X-ray Diffraction in Crystallography
- Marine Sponges and Natural Products
- Phenothiazines and Benzothiazines Synthesis and Activities
- Crystallization and Solubility Studies
- Cytokine Signaling Pathways and Interactions
Bezmiâlem Vakıf Üniversitesi
2017-2025
Istanbul University
2023
Foundation University Islamabad
2021
Atatürk University
2016-2018
Abstract In this study, imines bearing quinazolin‐4(3 H )‐one were synthesized and their inhibitory properties investigated against some metabolic enzymes including Acetylcholinesterase (AChE), Butyrylcholinesterase (BChE), α‐Glycosidase (α‐Gly), human Carbonic Anhydrase I–II (hCA I–II). All compounds had strength with K i values in the range of 38.55±4.08–159.05±10.68 nM 41.04±6.73–177.12±8.06 hCA I hCA‐II, respectively comparison to standard acetazolamide (AZA) =125.15±0.78 (for hCA‐I)...
In this study, new quinazoline-chromene hybrid compounds were synthesized. The cytotoxic effects on cell viability of the tested against A549 human lung adenocarcinoma and BEAS-2B healthy bronchial epithelial lines in vitro. addition, ability active to inhibit migration was tested. Molecular docking studies performed evaluate ligand-protein interactions, molecular dynamics simulations determine interactions stability complexes. silico absorption, distribution, metabolism, excretion (ADME)...
Abstract Herein, new derivatives of α , β‐ unsaturated ketones based on oleanolic acid ( 4 a – i ) were designed, synthesized, characterized, and tested against human prostate cancer (PC3). According to the in vitro cytotoxic study, title compounds showed significantly lower toxicity toward healthy cells (HUVEC) comparison with reference drug doxorubicin. The lowest IC 50 values PC3 cell lines b (7.785 μM), c (8.869 e (8.765 μM). results ADME calculations that drug‐likeness parameters within...
In this study, twenty new anthranilic acid hydrazones 6-9 (a-e) were synthesized and their structures characterized by Fourier-transform Infrared (FT-IR), Nuclear Magnetic Resonance (1 H-NMR - 13 C-NMR), High-resolution Mass Spectroscopy (HR-MS). The inhibitory effects of the compounds against COX-II evaluated. IC50 values found in range >200-0.32 μM 6e, 8d, 8e, 9b, 9c, 9e determined to be most effective inhibitors. Cytotoxic potent investigated human hepatoblastoma (Hep-G2) healthy...
Abstract In this study, starting from 3‐amino‐thiophene‐2‐carboxylic acid methyl ester, eighteen new arylidenehydrazide derivatives (4 – 21) were synthesized. To determine cytotoxic activity of target compounds they tested against human colon cancer and umbilical vein endothelial cell lines. prospective inhibition mechanism, binding affinity complex stability molecular docking dynamics studies carried out on transforming growth factor beta‐2 (TGFβ2) vascular receptor 2 (VEGFR2) proteins....
Sorafenib, a multiple kinase inhibitor, is widely used as first-line treatment for hepatocellular carcinoma. However, there need more effective alternatives when sorafenib proves insufficient. In this study, we aimed to design structure that surpasses sorafenib's efficacy, leading us synthesize sorafenib–ruthenium complexes the first time and investigate their properties. Our results indicate exhibit superior epidermal growth factor receptor (EGFR) inhibition compared alone. Interestingly,...
Abstract This study focused on the synthesis and evaluation of biological activity ten novel acetohydrazide hybrid derivatives, having furfuryloxy‐1,2,3‐triazole ring. All target compounds were tested in vitro silico for their inhibitory potential against key enzymes: hAChE, hBChE, hCAI, hCAII, all involved significant physiological processes. Remarkably, two compounds, namely (E)‐2‐(4‐((furan‐2‐ylmethoxy)methyl)‐1H‐1,2,3‐triazol‐1‐yl)‐N′‐(4‐hydroxy‐3‐methoxybenzylidene)acetohydrazide (9)...
Abstract In this study, we synthesized 15 novel quinazoline‐morpholinobenzylideneamino hybrid compounds from methyl anthranilate and assessed their cytotoxicity via in vitro assays against A549 BEAS‐2B cell lines. Molecular docking studies were conducted to evaluate the protein‐ligand interactions inhibition mechanisms on nine different molecular targets, while dynamics (MD) simulations carried out assess stability of best docked ligand–protein complexes. Additionally, ADME prediction was...
Abstract Cancer is one of the most common and lethal disease in world, therefore, patients need new potent anticancer agents for treatment. In this study, starting from vanillin, 24 compounds, which are 12 thiosemicarbazone (4a‐h, 5i‐j, 6k) thiazolidin‐4‐one ( 7a‐h, 8i‐j 9k) derivatives, were synthesized characterized by Nuclear Magnetic Resonance (NMR), High‐Resolution Mass Spectroscopy (HRMS), Fourier‐transform Infrared (FTIR) techniques. vitro cytotoxic effects investigated on CCD‐1079Sk...
Abstract In this study, 16 new compounds were synthesized starting from methylparaben. These consist of eight arylidenehydrazide derivatives and thiazolidin‐4‐on derivatives. All tested against MCF‐7 breast cancer cells MCF10A healthy tissue to determine their anti‐cancer activity. Molecular docking studies also carried out receptor proteins related the growth factor understand inhibition mechanism. According results, 4‐furan‐2‐ylmethoxy)‐N‐(4‐oxo‐2‐phenylthiazolidin‐3‐yl)benzamide ( 5 a )...
A synthesized azo compound based on 4-amino antipyrine and its complexes with Ni(II) in solution solid phase is reported. The structures of these compounds have been testified by IR NMR spectroscopy. combined experimental theoretical approach was used. To study the structure properties compound, as well possible complex formation Ni(II), ab initio quantum-chemical calculations were carried out using Hartree-Fock (HF) method 6-31 G basis set electron density functional theory (DFT) hybrid...
Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate (OPCA) on a preclinical model MS. First, OPCA was synthesized semisynthetically and characterized. Then, mice with MOG35–55-induced experimental autoimmune/allergic encephalomyelitis (EAE) were given along reference drug (FTY720). Biochemical, cellular, molecular analyses performed in serum brain tissues to...
Abstract This study synthesized a total of 18 new anthranilic acid hydrazones and quinazolin‐4( 3H )‐one derivatives, evaluating their cytotoxicity against the MCF7 HUVEC cell lines. The anticancer effects these compounds interactions with estrogen receptor alpha (ERα) HER2 through molecular docking dynamics simulations. Cytotoxicity assays revealed that most exhibited higher selectivity for cells compared to cells, 12, 13, 14, 23, 29 showing superior efficacy over standard drug...