A5040530753- Dialysis and Renal Disease Management
- Complement system in diseases
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Renal function and acid-base balance
- Muscle and Compartmental Disorders
- Blood Pressure and Hypertension Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Erythropoietin and Anemia Treatment
- Electrolyte and hormonal disorders
- Platelet Disorders and Treatments
- Diabetes Treatment and Management
- Sodium Intake and Health
- Blood groups and transfusion
- Central Venous Catheters and Hemodialysis
- Cardiovascular Conditions and Treatments
- Hip and Femur Fractures
- Lymphatic System and Diseases
- Marine Invertebrate Physiology and Ecology
- Heart Rate Variability and Autonomic Control
- Cell Adhesion Molecules Research
- Parathyroid Disorders and Treatments
- Venomous Animal Envenomation and Studies
- Iron Metabolism and Disorders
- Bone health and osteoporosis research
Nagoya University
2015-2024
Nagoya City University
2011-2024
Kyoto University
2024
University of Oxford
2023
Sapporo Medical University
2013-2021
University of Tsukuba
2012-2021
Ibaraki Prefectural University of Health Sciences
2021
Tokyo Kasei University
2018-2021
Nagoya University Hospital
2015-2018
National Center of Neurology and Psychiatry
2015-2017
Both the identity and source of rodent collagenase(s) that mediates matrix remodeling in liver fibrosis remain elusive. We have recently demonstrated an unequivocal role for scar-associated macrophages (SAMs) spontaneous resolution sought to determine whether SAMs are metalloproteinase (MMP) 13 (collagenase 3), considered be primary interstitial collagenase rodents. In this study, we demonstrate association between MMP13 expression presence regression experimental fibrosis. mmp13 gene was...
To explore mechanisms by which SGLT2 inhibitors protect diabetic hearts from heart failure, we examined the effect of empagliflozin (Empa) on ultrastructure cardiomyocytes in noninfarcted region after myocardial infarction (MI). OLETF, a rat model type 2 diabetes, and its nondiabetic control, LETO, received sham operation or left coronary artery ligation 12 h before tissue sampling. Tissues were sampled posterior ventricle (i.e., remote rats with MI). The number mitochondria was larger small...
The mechanism by which SGLT2 inhibitors reduce cardiac events in diabetic patients remains unclear. Here, we examined the effects of an inhibitor on acute survival rate after myocardial infarction (MI) animal model type 2 diabetes mellitus (DM) and possible involvement modification metabolomes antioxidative proteins. MI was induced DM Otsuka Long-Evans Tokushima Fatty (OLETF) rats (LETO) control rats. Treatment with empagliflozin (10 mg/kg per day, 14 days) before reduced blood glucose...
Complement is the canonical innate immune system involved in host defense and tissue repair with clearance of cell debris. In contrast to robust armory mounted against microbial nonself-pathogens, complement selectively activated on altered self (i.e. apoptotic necrotic cells) instruct safe demise by poorly characterized mechanisms. Our data shed new light role C1q sensing nucleic acids (NA) rapidly exposed Jurkat T membranes driving C3 opsonization but without lytic membrane attack complex....
ESRD treated with dialysis is associated increased left ventricular hypertrophy, which, in turn, related to high mortality. Mineralocorticoid receptor antagonists improve survival patients chronic heart failure; however, the effects undergoing remain uncertain. We conducted a multicenter, open-label, prospective, randomized trial 158 receiving angiotensin-converting enzyme inhibitor or angiotensin type 1 antagonist and peritoneal without (control group) spironolactone for 2 years. As primary...
Peritoneal fibrosis (PF) causes ultrafiltration failure (UFF) and is a complicating factor in long-term peritoneal dialysis. Lymphatic reabsorption also may contribute to UFF, but little known about lymphangiogenesis patients with UFF peritonitis. We studied the role of mediator vascular endothelial growth factor-C (VEGF-C) human dialysate effluents, tissues, mesothelial cells (HPMCs). Dialysate VEGF-C concentration correlated positively dialysate-to-plasma ratio creatinine (D/P Cr) TGF-β1...
The characteristic features of chronic peritoneal injury with dialysis (PD) are submesothelial fibrosis and neoangiogenesis. Transforming growth factor (TGF)β vascular endothelial (VEGF)-A the main mediators neoangiogenesis, respectively; however, effect interaction between them on peritoneum is not well known. In this study, we investigated relationship TGF-β1 VEGF-A in inducing by use human tissues dialysate, cultured cells, animal models. concentration correlated dialysate-to-plasma ratio...
The human neuromuscular disease myasthenia gravis (MG) is characterized by the generation of autoantibodies reactive with nicotinic acetylcholine receptors (AChR) that cause loss AChR from end-plate resultant failure transmission. A role for complement (C) in has been suggested based upon morphological identification C at MG and effects inhibition murine models. Here we provide further evidence implicating C, specifically membrane attack complex (MAC), a mouse model MG. Mice deficient...
To determine whether mitral valve repair (MVR) under cardiopulmonary bypass would be an effective treatment for regurgitation in small-breed dogs.Retrospective case series.48 dogs (body weight, 1.88 to 4.65 kg [4.11 10.25 lb]; age, 5 15 years) with that underwent surgery between August 2006 and 2009.Cardiopulmonary was performed a circuit. After induction of cardiac arrest, annuloplasty performed, the chordae tendineae were replaced expanded polytetrafluoroethylene chordal prostheses....
Peritoneal fibrosis (PF) is an important complication of peritoneal dialysis (PD) therapy that often occurs in association with high transport rate and ultrafiltration failure (UFF). To study the possible pathogenic role connective tissue growth factor (CTGF) relationship PF UFF, dialysate CTGF contents ( n = 178) expression 61) were investigated by ELISA, real-time PCR, immunohistochemistry, situ hybridization. production without TGF-β 1 stimulation human mesothelial cells (HPMC) from spent...
Current studies suggest that mesenchymal stromal cells (MSCs) improve acute kidney injury (AKI) via paracrine/endocrine effects. We established human adipose tissue-derived (hASCs) cultured in low (2%) serum (hLASCs), which have great potential of tissue regeneration. The present study was performed to investigate the therapeutic effects hLASCs on AKI and clarify mechanisms involved. In serum, hASCs proliferated well, while bone marrow-derived (hBMSCs) did not. secreted higher levels...
Abstract Gene-deleted mice have provided a potent tool in efforts to understand the roles of complement and complement-regulating proteins vivo. In particular, deficient membrane regulators receptor 1-related gene/protein y, decay-accelerating factor, or CD59 demonstrated homeostatic relevance backcrossing between strains has revealed cooperativity regulation. mouse, genes encoding factor been duplicated show differential expression tissues, complicating interpretation extrapolation findings...
We have postulated that the diminished renal capacity to excrete sodium causes nocturnal blood pressure (BP) elevation, which enhances natriuresis in compensation for impaired daytime natriuresis. If such a mechanism holds, high BP during sleep at night may continue until excess is sufficiently excreted into urine. This study examined whether duration, defined as "dipping time," mean arterial began fall <90% of average became longer function deteriorated. Ambulatory measurements and urinary...
Objective We have shown that as renal function deteriorated, night-time fall in both blood pressure and urinary sodium excretion were diminished. also reported intake restriction diuretics normalized circadian rhythm from nondipper to dipper patterns. In this study, we investigated whether an angiotensin II receptor blocker, olmesartan, could restore fall. Methods Twenty patients with chronic kidney disease (13 men, seven women; mean age 44.8 ± 18.1 years; BMI 22.9 3.5 kg/m2) studied. At...
Study Design. A study was conducted to determine the association between polymorphism of transforming growth factor-β1 (TGF-β1) gene and ossification posterior longitudinal ligament (OPLL) prevalence. Objective. To examine whether T869→C TGF-β1 is associated with genetic susceptibility OPLL in Japanese subjects. Summary Background Data. In ligament, abnormal calcium metabolism. Several candidate genes are prevalence OPLL. ossified matrix chondrocytes adjacent cartilaginous areas OPLL,...
Summary CD59, the sole membrane regulator of attack complex complement, is broadly and abundantly expressed in man other mammals. In mouse, CD59 encoded by two homologous genes. The expression patterns functional roles proteins these genes, mCD59a mCD59b, have not been well characterized. Here we describe generation monoclonal polyclonal antibodies detecting specifically mCD59b. These reagents used to study function ascertain cell tissue distributions was distributed on endothelia,...
Inappropriate activation of complement contributes to pathology in diverse inflammatory diseases. Soluble recombinant forms the natural cell membrane regulators are effective animal models and some human However, their use is limited for reasons related cost, short half lives, propensity cause unwanted systemic effects. Some these limitations may be overcome by bacterial expression systems, specific targeting moieties, judicious choice regulator. Here we describe application strategies...
Summary Myasthenia gravis (MG) is a debilitating and potentially fatal neuromuscular disease characterized by the generation of autoantibodies reactive with nicotinic acetylcholine receptors (AChR) that cause loss AChR from endplate resultant failure transmission. A role for complement (C) in pathology human MG has been suggested based upon identification C activation products plasma deposited at MG. In rat model, experimental autoimmune (EAMG), depletion or inhibition restricts clinical...