A5102860650- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Vasculitis and related conditions
- Chronic Kidney Disease and Diabetes
- Renal function and acid-base balance
- Systemic Lupus Erythematosus Research
- Mesenchymal stem cell research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Renal and Vascular Pathologies
- Sarcoidosis and Beryllium Toxicity Research
- Tissue Engineering and Regenerative Medicine
- Electrolyte and hormonal disorders
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Systemic Sclerosis and Related Diseases
- Complement system in diseases
- Autoimmune Bullous Skin Diseases
- Mycobacterium research and diagnosis
- Nutrition and Health in Aging
- Central Venous Catheters and Hemodialysis
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Blood disorders and treatments
- Heart Failure Treatment and Management
- Renal Transplantation Outcomes and Treatments
Aichi Medical University
2018-2025
Aichi Medical University Medical Center
2022-2025
Otsu Municipal Hospital
2020-2025
University Medical Center
2023
Nagoya University
2013-2022
Hokkaido University
2021
Yazaki (Japan)
2020
Aichi Medical University Hospital
2019
Nagoya University Hospital
2015
Fujita Health University
2015
OBJECTIVES: No bowel preparation for colonoscopy achieves optimal efficacy and tolerability. Combining polyethylene glycol plus ascorbic acid (PEG-Asc) with adjuvants has been explored to enhance cleansing reduce the required volume. This study aimed evaluate whether adding 0.5 mg linaclotide 1-L PEG-Asc (1 L-PEG/AL) improves superior compared 24 senna L-PEG/AS), which we previously reported be non-inferior standard regimen of 2 L PEG-Asc. METHODS: A multicenter, endoscopist-blinded,...
Objective Presepsin is highlighted as a diagnostic and prognostic marker of sepsis. Little information available regarding the accurate association between presepsin levels degree kidney function. We analyzed in patients with glomerular filtration rate (GFR) categories G1 to G5, evaluated via inulin renal clearance test, receiving hemodialysis (HD). Methods Patients who were not HD included if they had undergone measurements for measurement GFR (measured GFR), (HD) anuria. Exclusion criteria...
In addition to classically activated macrophages that have effector roles in tissue injury, alternatively M2 are involved the resolution of inflammation animal models kidney disease. To clarify clinical relevance macrophage phenotypes human glomerular diseases, we evaluated renal accumulation and plasma urine levels CD163, an marker, lupus nephritis (LN) patients. Kidney biopsies samples were obtained from LN patients who underwent biopsy between 2008 2012. CD163+, CD68+ CD204+ cells counted...
Current studies suggest that mesenchymal stromal cells (MSCs) improve acute kidney injury (AKI) via paracrine/endocrine effects. We established human adipose tissue-derived (hASCs) cultured in low (2%) serum (hLASCs), which have great potential of tissue regeneration. The present study was performed to investigate the therapeutic effects hLASCs on AKI and clarify mechanisms involved. In serum, hASCs proliferated well, while bone marrow-derived (hBMSCs) did not. secreted higher levels...
Mesenchymal stromal cells (MSCs) derived from adipose tissue have immunomodulatory effects, suggesting that they may therapeutic potential for crescentic GN. Here, we systemically administered adipose-derived (ASCs) in a rat model of anti-glomerular basement membrane (anti-GBM) disease and found this treatment protected against renal injury decreased proteinuria, crescent formation, infiltration by glomerular leukocytes, including neutrophils, CD8+ T cells, CD68+ macrophages. Interestingly,...
Methotrexate (MTX) is currently used as first‐line anchor drug for rheumatoid arthritis (RA). Therefore, the number of MTX‐associated lymphoproliferative disorders, including Epstein–Barr virus‐positive mucocutaneous ulcer (EBVMCU), has increased. Some aspects EBVMCU (MTX‐EBVMCU), particularly clinical behavior and treatment RA after MTX cessation, have not been well described. Herein, we report nine cases MTX‐EBVMCU with information regarding RA. Seven patients showed spontaneous regression...
Kidney biopsy • Indication of kidney in adults children Percutaneous native under the ultrasonic guidance Open (surgical) and laparoscopic Relative contraindication for percutaneous Bleeding complications
Fabry disease (FD) is a rare X-linked lysosomal storage disorder. Enzyme replacement therapies (ERT), such as agalsidase α and β, are available treatment options. While infusion-related reactions (IRRs) known to occur at the initiation of ERT owing immune responses, there limited information on IRRs during long-term ERT. We report case female patient with who developed unexpected hypotension after six years stable α, leading switch β. Continuous monitoring may be essential identify potential...
Background Acute kidney injury (AKI) is a critical condition associated with high mortality. However, the available treatments for AKI are limited. Stem cells from human exfoliated deciduous teeth (SHED) have recently gained attention as novel source of stem cells. The purpose this study was to clarify whether SHED therapeutic effect on induced by ischemia-reperfusion injury. Methods left renal artery and vein mice were clamped 20 min induce ischemia. SHED, bone marrow derived mesenchymal...
Background Idiopathic membranous nephropathy (IMN) is increasingly seen in older patients. However, differences disease presentation and outcomes between younger IMN patients remain controversial. We compared patient characteristics Methods recruited 171 Japanese with IMN, including 90 (52.6%) <65 years old, 40 (23.4%) 65–70 years, 41 (24.0%) ≥71 years. Clinical were Results During a median observation period of 37 months, 103 (60.2%) achieved complete proteinuria remission, which was not...
Objective. The diagnostic values of antiproteinase 3 and antimyeloperoxidase tests using antineutrophil cytoplasmic antibodies (ANCA) are well established. Our study determined whether an increase in ANCA level was a predictor disease flareup. Methods. included 126 patients with ANCA-associated renal vasculitis treated at 9 nephrology centers Japan. relationship between increased levels relapse assessed time-dependent multivariate Cox regression models adjusted for clinically relevant...
Nonsteroidal anti-inflammatory drugs (NSAIDs) have long-term benefits but are limited by side effects. We assessed the health and economic burden of renal events associated with NSAID use in patients osteoarthritis (OA) and/or chronic low back pain (CLBP). This retrospective, large-scale, medical claims database study Japanese receiving NSAIDs for OA CLBP between 2009 2018 incidence effect treatment duration, mode administration, usage consistency NSAIDs. Of 180,371 patients, were prescribed...
Abstract Lupus nephritis (LN) is a life-threatening complication of systemic lupus erythematosus. The 2003 pathological classification LN was revised in 2016; it quantitatively evaluates the interstitium addition to glomeruli. We performed retrospective multi-centre cohort study and investigated utility 2016 classification—including activity index (AI), chronicity (CI), each component predict complete remission or renal function decline, defined as 1.5-fold increase serum creatinine...
Background A non-invasive diagnostic marker of membranous nephropathy (MN) is desirable. The urinary level podocalyxin (PCX) higher in various glomerular diseases, including MN. aim this study was to construct a model MN with the combination PCX and clinical parameters. Methods We performed cross-sectional models for by using data samples from multicenter kidney biopsy registry Nagoya University its affiliated hospitals. Urinary (u-) measured sandwich ELISA. constructed 3 types 105 training...
Peritonitis is a major and the most significant complication of peritoneal dialysis (PD). Although some predictors peritonitis in PD patients are known, association between proton pump inhibitor (PPI) use has not been characterized. Here, we examined whether PPI risk factor for development peritonitis, based on single-center retrospective analysis 230 consecutive Japanese at Narita Memorial Hospital. We assessed subsequent first episode using multivariate Cox proportional hazards models,...
ABSTRACT Thrombotic microangiopathy is characterised by endothelial cell injury, intravascular platelet-fibrin thrombi, and vascular damage, leading to acute kidney thrombocytopenia, microangiopathic haemolytic anaemia. Among the autoimmune diseases related thrombotic microangiopathy, anti-neutrophil cytoplasmic antibody-associated vasculitis-related cases have been rarely reported; therefore, optimal treatment for associated remains unknown. An 84-year-old woman without significant medical...
Saka Y, Furuhashi K, Katsuno T, Kim H, Ozaki Iwasaki Haneda M, Sato W, Tsuboi N, Ito Matsuo S, Kobayashi Maruyama S. Adipose‐derived stromal cells cultured in a low‐serum medium, but not bone marrow‐derived cells, impede xenoantibody production. Xenotransplantation 2011; 18: 184–196. © 2011 John Wiley & Sons A/S. Abstract: Background: Although the immunomodulatory effects of mesenchymal (MSC) on T have been elucidated, little is known about their B cells. Recently, we established novel...