A5082732871- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Ion Transport and Channel Regulation
- Renal cell carcinoma treatment
- Electrolyte and hormonal disorders
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Complement system in diseases
- Liver Disease and Transplantation
- Pediatric Urology and Nephrology Studies
- Gallbladder and Bile Duct Disorders
- Abdominal Trauma and Injuries
- Neuroscience and Neuropharmacology Research
- Viral gastroenteritis research and epidemiology
- Genetics and Neurodevelopmental Disorders
- Renal function and acid-base balance
- Pancreatic and Hepatic Oncology Research
- Pregnancy and preeclampsia studies
- Ion channel regulation and function
- Renal Transplantation Outcomes and Treatments
- Adolescent and Pediatric Healthcare
- Clinical Nutrition and Gastroenterology
- Organic Chemistry Cycloaddition Reactions
- Histiocytic Disorders and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
Osaka University of Pharmaceutical Sciences
2021-2024
Osaka Medical and Pharmaceutical University
2006-2021
University of Tsukuba
2014-2021
Municipal Hirakata City Hospital
2013-2021
Japanese Society of Nephrology
2019
Tokyo Women's Medical University
2011
Nagoya University
2011
Tokyo Metropolitan Komagome Hospital
2009-2010
Pediatrics and Genetics
2009
Yamaguchi University
2005-2006
Abstract Rapid eye movement (REM) sleep deprivation (RSD) is known to impair learning and memory. Previous studies have demonstrated that RSD induces an impairment of hippocampal long‐term potentiation (LTP). In most these studies, was set up prior LTP induction. this work, we focused on after We investigated the effect for 24–48 h induction in dentate gyrus maintenance whether a REM rebound 48 affected LTP. rats were deprived by stroking their backs using brush, whereas control allowed...
Kidney biopsy • Indication of kidney in adults children Percutaneous native under the ultrasonic guidance Open (surgical) and laparoscopic Relative contraindication for percutaneous Bleeding complications
Although Kupffer cells (KCs) play an important role in the liver's immune response, their colon cancer metastasis to liver is unclear. We here analyzed relationship between KCs and tumor (TCs) liver. Fischer 344 (F344) rats were divided into control group (KC+ group) KC elimination (KC‑ group), which was induced by Cl2MDP liposome injection. RCN‑H4 injected of both groups, two types observed intravital microscopy (IVM) for 6 h. Moreover, investigate effect on formation, eliminated at...
The relationship between the degree of exposure and biological effects acrylonitrile (AN) was studied in 102 workers whose period exceeded five years, 62 matched controls, all whom had been randomly sampled from six acrylic fibre factories Japan. were classified into three groups on basis AN concentration at workplaces. most highly exposed group subjects showed an eight-hour average 4-2 ppm by personal sampling, a mean urinary 360 microgram/1 thiocyanate 11-4 mg/1. Medical examination,...
Abstract Background Practice patterns and bleeding complications of percutaneous native kidney biopsy (PNKB) have not recently been investigated the Japanese Society Nephrology performed a nationwide questionnaire survey in 2018. Methods The consisted nine sections about PNKB: (1) general indications; (2) indications for high-risk patients; (3) informed consent; (4) pre-biopsy evaluation; (5) procedures; (6) sedation; (7) post-biopsy hemostasis, bed rest, examinations; (8) complications; (9)...
Abstract: An infantile case of hemophagocytic syndrome (HPS) with systemic juvenile idiopathic arthritis (s‐JIA), refractory to methylprednisolone pulse therapy and cyclosporine A administration, was successfully treated by plasma exchange. The patient a one‐year‐old Japanese girl who had developed recurrent steroid‐dependent signs, including fever, skin eruption, hepatopathy, while in France, where she been diagnosed as having s‐JIA at eight months age. As high fever rheumatoid rash were...
Rotavirus gastroenteritis is severe and often results in dehydration pre-renal azotemia. However, we have encountered four children with acute obstructive uropathy associated rotavirus gastroenteritis, several similar cases been reported. Therefore, the aim of present study was to clarify epidemiology clinical features Japanese children.We sent questionnaires all members Society for Nephrology authors who had published case reports this disease Japan, inquiring about patient age at...
Abstract Methamphetamine (MA) abuse induces deficits in cognitive performance that are related to dysfunction of the prefrontal cortex (PFC). The medial portion (mPFC) rats is crucial for function has been shown undergo long‐term potentiation (LTP) projections from hippocampus. However, no study performed evaluate influence MA on synaptic plasticity hippocampal–mPFC pathways. In present experiments, we investigated effects repeated administration LTP, together with MA‐induced stereotyped...
Chikamoto H, Hattori M, Kuroda N, Kajiho Y, Matsumura Fujii Ishizuka K, Hisano Akioka Nozu Kaito Shimizu M. Pretransplantation combined therapy with plasmapheresis and rituximab in a second living‐related kidney transplant pediatric recipient very high risk for focal segmental glomerulosclerosis recurrence. Pediatr Transplantation 2011. © 2011 John Wiley & Sons A/S. Abstract: Prophylactic PP can provide some protection against post‐transplantation recurrences of FSGS, but it cannot...
To investigate the effect of mild steatotic liver on ischemia-reperfusion injury by focusing Kupffer cells (KCs) and platelets.Wistar rats were divided into a normal group (N group) (S induced feeding choline-deficient diet for 2 wk. Both groups subjected to 20 min warm ischemia followed 120 reperfusion. The number labeled KCs platelets in sinusoids blood perfusion observed intravital microscopy (IVM), which was performed at 30, 60 after evaluate serum alanine aminotransferase as marker...
Rotavirus gastroenteritis is severe and often results in dehydration pre-renal azotemia. In addition, some patients with acute obstructive uropathy due to ammonium acid urate stones, developing approximately 6-7 days after the onset of rotavirus gastroenteritis, have been reported, mainly Japan. The pathophysiological mechanism responsible for stone formation has not clarified. present study, we investigated clinical characteristics these patients, analyzed pathophysiology underlying urinary...
<i>Background/Aims:</i> Basically, patients with cancer of the major duodenal papilla should undergo pylorus-preserving pancreatoduodenectomy; however, adenoma or in do not require prophylactic lymph node dissection, so they are indicated for limited resection papilla. Endoscopic snare (ESR) has developed as papilla; ESR technique is still restricted to certain centers, because its outcome depends on technical skills endoscopist. Therefore, we attempted laparoscopy-assisted...
Background Oxidative stress is a major factor responsible for minimal-change nephrotic syndrome (MCNS), which occurs most commonly in children. However, the influence of oxidative localized to mitochondria remains unclear. We examined effect mitochondrion-targeting antioxidant, MitoTEMPO, rats with puromycin aminonucleoside (PAN)-induced MCNS clarify degree mitochondrial affects MCNS. Materials and methods Thirty Wistar were divided into three groups: normal saline group (n = 7), PAN 12), +...
Recent studies have indicated that reactive oxygen species (ROS) play a role in the pathogenesis of glomerular injury leading to proteinuria nephrotic syndrome. In present investigation, we examined effects radical scavenger edaravone administered at various time points rats with puromycin nephrosis.35 Wistar were divided into five groups: treatment aminonucleoside (PAN) alone, PAN followed by early period, administration late and for whole experimental untreated controls. On Days 3, 6 9,...
Glucocorticoid therapy has a number of adverse effects, among which osteoporosis and bone fracture can be major complications. Immunosuppressive for nephrotic syndrome is effective help to reduce the cumulative dose glucocorticoids. Therefore, this reason, patients with who develop glucocorticoid-related osteoporotic compression decreasing. Here we describe pediatric case multiple vertebral fractures due glucocorticoid-induced during treatment syndrome.A 12-year-old boy was treated standard...
Abstract Retinol and its metabolite retinoic acid play a critical role in immunity, reproduction, development. Retinoids are known to influence renal development, show beneficial effects experimental models of disease. ß‐Carotene (provitamin A) is cleaved retinal by ß‐carotene 15,15′‐ monooxygenase (BCM), which an essential enzyme for retinoid biosynthesis. However, the metabolism retinol diseases such as nephrosis remains unclear. We studied BCM gene expression status rats with nephrotic...
Liver steatosis increases the risk of postoperative complications following major liver resection, since steatotic is susceptible to ischemia-reperfusion (IR) injury. However, it unclear how IR injury changes in relation degree hepatic steatosis. Previously, we reported that interaction between Kupffer cells (KCs) and platelets induced The aim our present study was evaluate relationship by focusing on KCs platelets. Mild moderate models were generated Wistar rats feeding a choline-deficient...
Abstract Introduction: During laparoscopic cholecystectomy, an enlarged field of vision increases safety and precision, but surgeons often encounter bleeding that can cause difficulties. It is important to prevent control arterial from Calot's triangle the liver bed results injury deep branch cystic artery (DBCA). However, no previous reports have mentioned layer between gallbladder through which DBCA runs. Materials Surgical Technique: To determine this layer, we investigated histological...
We report the use of three dimensional computational analysis chloride channel 5 (ClC-5) based on a novel mutation, L266V, identified in 15-year-old Japanese boy with Dent's disease. Since both leucine and valine are branched-chain amino acids, it has not been proved conclusively whether L266V mutation is actually responsible for development In present study using molecular analysis, we investigated mechanism loss function ClC-5 protein resulting from mutation. Structural normal...