A5060223389- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic function and diabetes
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Clinical Nutrition and Gastroenterology
- Glycosylation and Glycoproteins Research
- Hepatitis Viruses Studies and Epidemiology
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Pancreatitis Pathology and Treatment
- Transplantation: Methods and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- Nanoparticle-Based Drug Delivery
- Cardiac Ischemia and Reperfusion
- Surgical Simulation and Training
- Immune Cell Function and Interaction
University of Tsukuba
2014-2023
National Hospital Organization Mito Medical Center
2019-2022
Jiangsu University
2016-2021
Affiliated Hospital of Jiangsu University
2016-2021
Wuyi University
2021
Yokohama City University
2016-2021
University of Tsukuba Hospital
2014-2020
Henry Ford Hospital
2018
Tokyo Medical University Ibaraki Medical Center
2016
Regenerative Medicine Institute
2016
This study examines the applicability of platelet infusion therapy for liver regeneration in vivo.We recently reported that platelets accumulate immediately after extended hepatectomy and promote residual regeneration. Liver depends on number accumulated sinusoids.Male Sprague-Dawley rats underwent 70% were then assigned to groups infused with 1 mL either platelet-rich plasma (PRP; × 10(9) platelets/mL) normal saline (NS) or NS via portal vein. We analyzed signaling pathways are related...
Epirubicin is widely used to treat various human tumors. However, it difficult achieve a sufficient antitumor effect because of dosage limitation prevent cardiotoxicity. We hypothesized that epirubicin-incorporating micelle would reduce cardiotoxicity and improve the effect. NC-6300 comprises epirubicin covalently bound PEG polyaspartate block copolymer through an acid-labile hydrazone bond. The conjugate forms micellar structure 40-80 nm in diameter aqueous milieu. (10, 15 mg/kg) (10 were...
The use of ferromagnetic nanoparticles for hyperthermia and thermoablation therapies has shown great promise in the field nanobiomedicine. Even local offers numerous advantages as a novel cancer therapy; however, it requires remarkably high heating power more than 1 kW g −1 heat agents. As candidate generation, we focus on compare their physical properties with those superparamagnetic substances. Numerical simulations ideal single-domain cubic uniaxial magnetic symmetries were carried out MH...
Several recent studies have reported that liver cirrhosis (LC) can be ameliorated, but few adequate strategies are available against fibrosis. Although LC clinically shows thrombocytopenia and hypersplenism, the correlation with fibrosis platelets remains unclear. The aim of present study was to investigate effect on in mouse models.To induce fibrosis, C57BL6 female mice were injected i.p. 1 mL/kg carbon tetrachloride (CCl(4)) twice a week for 8 weeks. Thrombocytosis achieved by giving...
Fatty acid synthase (FAS) is highly expressed in many kinds of human cancers, including colorectal cancer (CRC), and we have investigated the potential use FAS inhibitors for chemoprevention liver metastasis CRC mice. Expression was evaluated murine cell lines Colon 26 CMT 93. Cerulenin, a natural inhibitor FAS, induced apoptosis these lines. The ability cerulenin to prevent development metastatic lesions evaluated. numbers sizes tumors were significantly reduced by treating mice with...
Cholangiocarcinoma (CC) is an aggressive malignant tumor for which useful markers are not presently available early and precise diagnosis. The aim of this study was therefore to identify a high-performance diagnostic marker with special focus on glyco-alteration glycoproteins. In the course study, we found that Wisteria floribunda agglutinin (WFA) best probe differentiate intrahepatic cholangiocarcinoma (ICC) lesions from normal bile duct epithelia (BDE) ( P < 0.0001). subsequent...
To investigate the anticancer mechanisms of monoterpenoid alcohol linalool in human colon cancer cells.The cytotoxic effect on cell lines and a fibroblast line was examined using WST-8 assay. The apoptosis-inducing measured terminal deoxynucleotidyl transferase dUTP nick-end labeling assay flow cytometry with Annexin V. Oxidative stress investigated by staining for diphenyl-1-pyrenylphosphine, which is cellular lipid peroxidation marker, electron spin resonance spectroscopy. Sixteen SCID...
Impaired drug transport is an important factor that reduces the efficacy of anticancer agents against pancreatic cancer. Here, we report a novel combination chemotherapy using gemcitabine (GEM) and internalised-RGD (iRGD) peptide, which enhances tumour-specific penetration by binding neuropilin-1 (NRP1) receptor. A total five cancer murine models (two cell line-based xenografts (CXs) three tumour grafts (TGs)) were treated with either GEM (100 mg kg−1, q3d × 4) alone or plus iRGD peptide (8...
When a cell undergoes apoptosis, phosphatidylserine (PS) is exposed on the outer leaflet of plasma membrane. PS acts as an “eat-me” signal to direct phagocytes expressing receptors engulf apoptotic cell. We recently reported that immunoreceptor CD300a, which expressed myeloid cells, receptor. show CD300a does not facilitate macrophage phagocytosis cells. Instead, delivers inhibitory in mast cells suppress production LPS-induced inflammatory cytokines and chemokines. After cecal ligation...
BACKGROUND The high prevalence of specific immunoglobulin G for hepatitis E virus (HEV) in Japanese people raises the possibility a incidence HEV‐viremic blood donors and therefore frequent transfusion‐transmitted HEV (TT‐HEV). STUDY DESIGN AND METHODS TT‐HEV cases established Japan through hemovigilance those published literature were collected. Infectivity HEV‐contaminated components disease severity relation to immunosuppression investigated. RESULTS Twenty recorded over past 17 years. A...
AIMTo reveal better diagnostic markers for differentiating neuroendocrine tumor (NET) from solid-pseudopapillary neoplasm (SPN), focusing primarily on immunohistochemical analysis. METHODSWe reviewed 30 pancreatic surgical specimens of NET (24 cases) and SPN (6 cases).We carried out comprehensive profiling using 9 markers: Synaptophysin, chromogranin A, pancytokeratin, E-cadherin, progesterone receptor,
Abstract Background In the past decade, three‐dimensional (3D) simulation has been commonly used for liver surgery. However, few studies have analyzed usefulness of this 3D simulation. The aim study was to evaluate effect on outcome Methods We retrospectively 240 consecutive patients who underwent resection. were divided into two groups: those received preoperative (“3D group”, n = 120) and did not undergo (“without 120). perioperative outcomes, including operation time, blood loss, maximum...
Nonalcoholic steatohepatitis (NASH) is the most severe and progressive form of nonalcoholic fatty liver disease (NAFLD), which can lead to life-threatening conditions, however, there still no approved drug for treatment NASH. In this study we used human-like NASH mouse model treated orally with isorhamnetin at a dose 50 mg/kg analyze effect on progression NASH-induced mice represented steatosis inflammation, fibrosis in accompanied high level injury markers serum. Isorhamnetin reduced...