A5007941258- Glycosylation and Glycoproteins Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cancer Research and Treatments
- Fluid Dynamics and Mixing
- Monoclonal and Polyclonal Antibodies Research
- Photonic and Optical Devices
- Semiconductor materials and devices
- Liver Disease Diagnosis and Treatment
- Silicon and Solar Cell Technologies
- Vitamin C and Antioxidants Research
- Skin Protection and Aging
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Bee Products Chemical Analysis
- Organic Electronics and Photovoltaics
- Integrated Circuits and Semiconductor Failure Analysis
- Laser Design and Applications
- Heat Transfer and Boiling Studies
- Thin-Film Transistor Technologies
- Electron and X-Ray Spectroscopy Techniques
- Pancreatic and Hepatic Oncology Research
- Genomics, phytochemicals, and oxidative stress
- Pancreatitis Pathology and Treatment
- Advancements in Semiconductor Devices and Circuit Design
- EEG and Brain-Computer Interfaces
National Center of Neurology and Psychiatry
2023-2024
Shibaura Institute of Technology
2024
Tokyo Institute of Technology
2023
Academy of Sciences Malaysia
2022
Mitsui & Co (Japan)
2022
Chiba University
2012-2021
University of Tsukuba
2006-2021
University of Tsukuba Hospital
2021
Aoyama Gakuin University
2021
Ogori Daiichi General Hospital
2020
Abstract Mechanical stress and aging are major risk factors of cartilage degeneration. Human studies have previously reported that oxidative damage increased, while SOD2 protein was reciprocally downregulated in osteoarthritic degenerated cartilage. However, it remains unclear whether mitochondrial superoxide imbalance chondrocytes causes We herein demonstrate mechanical loading promoted generation selective Sod2 downregulation vivo inducer also expression vitro . A genetically manipulated...
Cu-Zn superoxide dismutase (Sod1) loss causes a redox imbalance as it leads to excess generation, which results in the appearance of various aging-related phenotypes, including skin atrophy. Noble metal nanoparticles, such palladium (Pd) and platinum (Pt) are considered function antioxidants due their strong catalytic activity. In Japan, mixture Pd Pt nanoparticles called PAPLAL has been used treat chronic diseases over past 60 years. present study, we investigated protective effects against...
Abstract Osteocytes are major bone cells that play a crucial role in maintaining the quality of and healing damage to tissue. The number living osteocytes canalicular networks declines an age-dependent manner. However, pathological effects mitochondrial redox imbalances on metabolism have not been fully elucidated. We generated mice lacking superoxide dismutase 2 ( Sod2 ) osteocytes. Like aged bone, depletion positively enhanced production cellular vivo . A morphological analysis...
Oxidative stress is related to the pathogenesis of Alzheimer's disease (AD) characterized by progressive memory impairment. Soluble amyloid-β (Aβ) oligomers cause cognitive loss and synaptic dysfunction rather than senile plaques in AD. The decline o
The film morphology and device performance of planar heterojunction solar cells based on the molecular donor material α-sexithiophene (6T) are investigated. Planar heterojunctions 6T with two different acceptor molecules, C60 fullerene diindenoperylene (DIP), have been prepared. growth temperature bottom layer has varied between room 100 °C for each acceptor. By means X-ray diffraction absorption, we show that crystallinity orientation is influenced by preparation conditions templates...
A tris(7-propyl-8-hydroxyquinolinato) aluminum [Al(7-Prq)3] film shows negative giant surface potential (GSP) because of spontaneous orientation polarization. The polarity this is opposite to those tris-(8-hydroxyquinolate) films. In Al(7-Prq)3-based organic light-emitting diodes, GSP leads the positive interface charge and governs electron injection accumulation properties. addition, a high resistance at Al(7-Prq)3/Ca suggested possibly polarization interface. These results show importance...
Nonalcoholic steatohepatitis (NASH) is the most severe and progressive form of nonalcoholic fatty liver disease (NAFLD), which can lead to life-threatening conditions, however, there still no approved drug for treatment NASH. In this study we used human-like NASH mouse model treated orally with isorhamnetin at a dose 50 mg/kg analyze effect on progression NASH-induced mice represented steatosis inflammation, fibrosis in accompanied high level injury markers serum. Isorhamnetin reduced...
Alzheimer's disease (AD) is characterized by progressive cognitive impairment and the formation of senile plaques. Silymarin, an extract milk thistle, has long been used as a medicinal herb for liver diseases. Here we report marked suppression amyloid β-protein (Aβ) fibril neurotoxicity in PC12 cells after silymarin treatment vitro. In vivo studies had indicated significant reduction brain Aβ deposition improvement behavioral abnormalities precursor protein (APP) transgenic mice that...
ABSTRACT Oxidative stress contributes to the pathogenesis of age-related diseases as well bone fragility. Our previous study demonstrated that copper/zinc superoxide dismutase (Sod1)-deficient mice exhibit induction intracellular reactive oxygen species (ROS) and fragility resulting from low-turnover loss impaired collagen cross-linking (Nojiri et al. J Bone Miner Res. 2011;26:2682–94). Mechanical also plays an important role in maintenance homeostasis tissue. However, molecular links...
Abstract Various cancers, including pancreatic ductal adenocarcinoma (PDAC), remain intractable even with costly tumor-targeting antibody drugs. Because the outermost coatings of cancer cells are composed cell-specific glycan layers (glycocalyx), lectins, proteins glycan-binding potential, were evaluated for possible use as drug carriers in PDAC treatment. A human cell line well-to-moderately differentiated properties (Capan-1) was subjected to lectin microarray analysis identify specific...
Age-related skin thinning is correlated with a decrease in the content of collagen skin. Accumulating evidence suggests that peptide (CP) and vitamin C (VC) transcriptionally upregulate type I vivo. However, additive effects CP VC on age-related changes remain unclear. We herein demonstrate derivative additively corrected via reduced oxidative damage superoxide dismutase 1 (Sod1)-deficient mice. Co-treatment these compounds significantly normalized altered gene expression Col1a1, Has2, Ci1,...
Superoxide dismutase 1 (SOD1) is an antioxidant enzyme that converts superoxide anion radicals into hydrogen peroxide and molecular oxygen. The senescence marker protein‐30 (SMP30) a gluconolactonase functions as protein in mammals due to its involvement ascorbic acid (AA) biosynthesis. SMP30 also participates Ca 2+ efflux by activating the calmodulin‐dependent ‐pump. To reveal role of oxidative stress lipid metabolism defects occurring non‐alcoholic fatty liver disease pathogenesis, we...
The complete electronic structure inside a practical organic photovoltaic (OPV) device consisting of trilayer copper‐phthalocyanine (CuPc), fullerene (C 60 ), and bathocuproine (BCP) is demonstrated using low‐energy ultraviolet photoelectron spectroscopy (LE‐UPS) yield (PYS). molecular orbital energy alignment electrostatic potential distribution throughout the entire illustrated based on LE‐UPS results. A favorable gradient to carry photogenerated holes electrons manifested be built...
The interplay between food components and gut microbiota has been considered an important factor affecting the functionality of health-promoting foods. In this study, effects probiotic Lactobacillus paracasei A221 on bioavailability kaempferol-3-o-sophroside (KP3S), a kaempferol-glucoside contained in kale, were investigated vitro vivo. Unlike type strain NBRC15889, converted standard KP3S as well kaempferol-glucosides kale extract into kaempferol (KP). Using intestinal barrier model,...
Oxidative damages induced by a redox imbalance cause age-related changes in cells and tissues. Superoxide dismutase (SOD) enzymes play major role the antioxidant system they also catalyze superoxide radicals (O2·-). Since loss of cytoplasmic SOD (SOD1) resulted aging-like phenotypes several types mouse tissue, SOD1 is essential for maintenance tissue homeostasis. To clarify cellular function SOD1, we investigated Sod1-deficient fibroblasts. We demonstrated that Sod1 deficiency impaired...
Abstract Apples are well known to have various benefits for the human body. Procyanidins a class of polyphenols found in apples that demonstrated effects on circulatory system and skeletal organs. Osteoarthritis (OA) is locomotive syndrome histologically characterized by cartilage degeneration associated with impairment proteoglycan homeostasis chondrocytes. However, no useful therapy has been developed date. In present study, we detected beneficial apple or their procyanidins homeostasis....
Aging is associated with motor disorders that decrease the quality of life (QOL). Royal jelly (RJ), used as a dietary supplement, has shown various health benefits and, therefore, it potential to improve QOL during aging. We have previously developed protease enzyme-treated RJ avoid anaphylactic response induced by supplementation. However, effects lifelong treatment on normal aging not been fully clarified. In this study, we investigated enzyme-untreated (NRJ) and (ERJ) process focusing...
BackgroundRotator cuff degeneration is 1 of several factors that lead to rotator tears; however, the mechanism this remains unclear. We previously reported deficiency an antioxidant enzyme, superoxide dismutase (Sod1), in mice induced supraspinatus tendon entheses, a model replicates human degeneration. In study, we analyzed possible effects vitamin C (VC), major antioxidant, on degenerative changes entheses Sod1−/− mice.MethodsWe administered VC or vehicle, distilled water, for 8 weeks and...
We fabricated high-quality strain-relaxed thin SiGe layers by Ar ion implantation into Si substrates before epitaxial growth. The surface of 100-nm-thick Si0.8Ge0.2 layers, the relaxation ratio which was more than 80%, found to be very smooth, with a rms roughness 0.34 nm. Cross-sectional transmission electron microscopy analysis confirmed that strain-relieving dislocations were effectively generated due ion-implantation-induced defects and confined in vicinity heterointerface, resulting...
Low-energy photoelectron spectroscopy combined with yield was developed to investigate the buried organic interfaces in practical device thickness. Ultralow background signal and charging durability were achieved by utilizing monochromatic low-energy photons. C60/rubrene/Au studied as a prototypical system of solar cells. The low density gap states detected rubrene film small feature due C60-induced morphological change observed C60/rubrene interface.
Although several non‐alcoholic steatohepatitis (NASH) models have been reported to date, few of these fully reflect the histopathology and pathophysiology human NASH. The aim this study was establish a novel NASH model by feeding high‐fat (HF) diet administering both carbon tetrachloride (CCl 4 ) Liver X receptor agonist T0901317. Male C57BL/6J mice were divided into four groups (each n = 5): HF, HF + CCl , T0901317, (HF T0901317). (0.1 mL/kg) T0901317 (2.5 mg/kg) intraperitoneally...