A5072667589- Genetics, Aging, and Longevity in Model Organisms
- melanin and skin pigmentation
- Ginseng Biological Effects and Applications
- Biochemical Analysis and Sensing Techniques
- Sirtuins and Resveratrol in Medicine
- Genomics, phytochemicals, and oxidative stress
- Skin Protection and Aging
- FOXO transcription factor regulation
- Pharmacological Effects of Natural Compounds
- Air Quality and Health Impacts
- Lipid metabolism and disorders
- Selenium in Biological Systems
- Diet and metabolism studies
- Nanoparticles: synthesis and applications
- Gut microbiota and health
- Mitochondrial Function and Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Cell Function and Interaction
- Medicinal Plants and Bioactive Compounds
- Electrochemical Analysis and Applications
- Flavonoids in Medical Research
- Psoriasis: Treatment and Pathogenesis
- Phytochemistry and Biological Activities
- Inflammatory Biomarkers in Disease Prognosis
Konkuk University
2024-2025
Gwangju Institute of Science and Technology
2023-2025
Amorepacific (South Korea)
2014-2023
Chiba University
2018-2019
The University of Tokyo
2008-2016
Food Research Institute
2015
A polyacrylic acid (PAA)-protected platinum nanoparticle species (PAA-Pt) was prepared by alcohol reduction of hexachloroplatinate. The PAA-Pt nanoparticles were well dispersed and homogeneous in size with an average diameter 2.0 +/- 0.4 nm (n = 200). We used electron spin resonance to quantify the residual peroxyl radical ([Formula: see text]) generated from 2,2-azobis (2-aminopropane) dihydrochloride (AAPH) thermal decomposition presence O(2) a spectrophotometric method...
Abstract The pathways that impact longevity in the wake of dietary restriction (DR) remain still ill-defined. Most studies have focused on nutrient limitation and perturbations energy metabolism. We showed L-threonine was elevated Caenorhabditis elegans under DR, supplementation increased its healthspan. Using metabolic transcriptomic profiling worms were fed with RNAi to induce loss key candidate mediators. loss-of-threonine dehydrogenaseincreased healthspan by attenuating ferroptosis a...
Korean ginseng (Panax ginseng) plays an anti-inflammatory role in a variety of inflammatory diseases such as gastritis, hepatitis, and colitis. However, inflammation-regulatory activity the calyx P. berry has not been thoroughly evaluated. To understand whether portion is able to ameliorate processes, ethanolic extract (Pg-C-EE) was prepared, lipopolysaccharide-activated macrophages HEK293 cells transfected with proteins were used test action Pg-C-EE. The ginsenoside contents Pg-C-EE...
The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective and cellular mechanism ginseng, especially P. calyx. To understand how an ethanol extract berry calyx (Pg-C-EE) exerts effects, we studied its activities activated melanocytes reactive oxygen species (ROS)-induced keratinocytes.To confirm effect Pg-C-EE, analyzed melanin synthesis secretion messenger RNA protein expression levels...
Abstract Age-associated immunological dysfunction (immunosenescence) is closely linked to perturbation of the gut microbiota. Here, we investigated whether syringaresinol (SYR), a polyphenolic lignan, modulates immune aging and microbiota associated with this effect in middle-aged mice. Compared age-matched control mice, SYR treatment delayed immunosenescence by enhancing numbers total CD3 + T cells naïve cells. induced expression Bim as well activation FOXO3 Foxp3 regulatory (Tregs)....
Antihyperglycemic effects of Panax ginseng berry have never been explored in humans. The aims this study were to assess the efficacy and safety a 12-wk treatment with extract participants fasting glucose level between 100 mg/dL 140 mg/dL. This was 12-wk, randomized, double-blind, placebo-controlled clinical trial. A total 72 randomly allocated two groups either or placebo, 63 completed study. parameters related metabolism assessed. Although present failed show significant antihyperglycemic...
The ginseng berry has various bioactivities, including antidiabetic, anticancer, antiinflammatory, and antioxidative properties. Moreover, we have revealed that the active antiaging component of berry, syringaresinol, ability to stimulate longevity via gene activation. Despite many known beneficial effects ginseng, its on skin aging are poorly understood. In this study, investigated one processes, melanogenesis, age-related pigment lipofuscin accumulation, elucidate mechanism action with...
// Siyoung Cho 1 , Miook 2 Juewon Kim Matt Kaeberlein 3 Sang Jun Lee and Yousin Suh 2,4,5 R&D Unit, Amorepacific Corporation, Yongin-si, Gyeonggi-do, Korea Department of Genetics, Albert Einstein College Medicine, Bronx, NY, USA Pathology, University Washington, Seattle, WA, 4 Diabetes Research Training Center, 5 Institute for Aging Research, Correspondence: Lee, email: Suh, Keywords : HIF-1α, Syringaresinol, FOXO3, ischemia/reperfusion, hypoxia/reoxygenation, cardiomyocytes...
MicroRNAs are known to be the important regulators of skin physiology and considered as new therapeutic targets treat diseases. In this study, miR-125b was identified a potent regulator steady-state melanogenesis. We found that expression inversely related pigment levels. A mimic decreased pigmentation-related gene melanin content, implying functions decrease pigmentation. Moreover, we observed reduction in pigmented cells at least partially due hypermethylation MIR125B-1 promoter, regulated...
Korean ginseng has been widely evaluated to treat human diseases; however, most studies on have focused its root. In this study, polysaccharides [acidic-polysaccharide-linked glycopeptide (APGP) extracted with 90% ethanol and hot water] were prepared from berries, their effect immunosenescence was explored.The of APGP thymic involution by measuring the size thymi dissected aged mice. The populations immune cells, including natural killer (NK) dendritic age-correlated CD11c-positive B several...
The precise mechanisms of antioxidant-mediated longevity are poorly understood. We show that an antioxidant treatment can extend the lifespan Caenorhabditis elegans (C. elegans) through nuclear translocation forkhead box O transcription factor (FoxO) homolog DAF-16. This pathway was found to involve 3-phosphoinositide-dependent kinase-1 (PDK-1) and serum- glucocorticoid-regulated (SGK-1), distinct from known oxidative stress-mediated mechanism in which FoxO3a is regulated by c-Jun N-terminal...
Abstract Airborne fine dust particles (FDPs) have been identified as major toxins in air pollution that threaten human respiratory health. While searching for an anti-FDP reagent, we found green tea extract (GTE) and fractions rich flavonol glycosides (FLGs) crude polysaccharides (CTPs) had protective effects against FDP-stimulated cellular damage the BEAS-2B airway epithelial cell line. The GTE, FLGs, CTPs significantly increased viability lowered oxidative stress levels FDP-treated cells....
Demands for safe depigmentation compounds are constantly increasing in the pharmaceutical and cosmetic industry, since numerous relevant reported to date have shown undesirable side effects or low anti-melanogenic effects. In this study, we three novel inhibitors of tyrosinase, which is key enzyme melanogenesis, identified using docking-based high throughput virtual screening an in-house natural compound library followed by mushroom tyrosinase inhibition assay. Of compounds, gallacetophenone...
ABSTRACT Green tea intake is generally recognized as an effective supplement that promotes mental clarity and cognitive function. These health benefits of green have been attributed mainly to its component, epigallocatechin gallate (EGCG). Because various catechin derivatives potently enhance these benefits, we manipulated the extraction process with a high-temperature intervention. High-temperature-processed extract (HTP-GTE) showed elevated proportion gallocatechin (GCG) content. To...
Skin aging is a major risk factor for the dermal diseases, and interventions to attenuate cellular senescence are expected reduce age-related diseases involving skin atrophy. However, blocking cell death or extending proliferation causally results in side effects an increased cancer risk. For identification of safer approach, we focused on PDK1 inhibition, which could revert factors vitro, human equivalent model exploratory, placebo-controlled, interventional trial. Natural phytochemical...
A recent trial in the development of new medications and immune-modulatory agents is to search for candidates among natural products because they have relatively low toxicities clinical applications.Ginseng has been used as a traditional medicine Asia demonstrated efficacy against various human diseases, such viral infectious diabetes, atherosclerosis, cancer.Recent studies cases enhanced interest potential biological effects ginseng berry, an association that appears be due phytochemical...
The skin of an organism is affected by various environmental factors and fights against aging stress via mechanical biochemical responses. Photoaging induced ultraviolet B (UVB) irradiation common the most vital factor in senescence phenotype skin, so, suppression UVB stress-induced damage critical. To lessen UVB-induced hyperimmune response hyperpigmentation, we investigated ameliorative effects intense pulsed light (IPL) treatment on photoaged cells. Normal human epidermal keratinocytes...