A5027977835- Skin Protection and Aging
- Hair Growth and Disorders
- melanin and skin pigmentation
- Nerve injury and regeneration
- Bee Products Chemical Analysis
- Advancements in Transdermal Drug Delivery
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Phytochemicals and Antioxidant Activities
- Extracellular vesicles in disease
- Body Contouring and Surgery
- Sympathectomy and Hyperhidrosis Treatments
- Lymphatic System and Diseases
- Skin and Cellular Biology Research
- Adipose Tissue and Metabolism
- Tea Polyphenols and Effects
- Cancer and Skin Lesions
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Silk-based biomaterials and applications
- Thermoregulation and physiological responses
- RNA regulation and disease
- Per- and polyfluoroalkyl substances research
- Coenzyme Q10 studies and effects
Amorepacific (South Korea)
2012-2024
Sungkyunkwan University
2014-2021
ABSTRACT Probiotics offer various health benefits. Lactobacillus plantarum has been used for decades to enhance human intestinal mucosal immunity and improve skin barrier integrity. Extracellular vesicles (EVs) derived from eukaryotic or prokaryotic cells have recognized as efficient carriers delivery of biomolecules recipient cells, efficiently regulate pathophysiology. However, the mechanism underlying beneficial effects probiotic bacteria‐derived EVs on is unclear. Herein, we investigated...
Background Alopecia is the common hair loss problem that can affect many people. However, current therapies for treatment of alopecia are limited by low efficacy and potentially undesirable side effects. We have identified a new function valproic acid (VPA), GSK3β inhibitor activates Wnt/β-catenin pathway, to promote re-growth in vitro vivo. Methodology/ Principal Findings Topical application VPA male C3H mice critically stimulated induced terminally differentiated epidermal markers such as...
Ginseng is a traditional herbal medicine in eastern Asian countries. Most active constituents ginseng are prepared via fermentation or organic acid pretreatment. Extracellular vesicles (EVs) released by most organisms from prokaryotes to eukaryotes and play central roles intra- inter-species communications. Plants produce EVs upon exposure microbes; however, their direct functions utility for human health barely known, except being proposed as delivery vehicles. In this study, we isolated...
The aim of this study was to develop a coenzyme Q10 (CoQ10) microemulsion system with improved solubility, penetration, and wound healing efficacy. Based on the pseudo-ternary diagram, microemulsions containing isopropyl myristate (IPM), Cremophor EL®, Transcutol® HP were selected confirmed be nanosized (<20 nm) thermodynamically stable based dilution thermodynamic stability tests. CoQ10-loaded surfactant/co-surfactant (S/CoS) ratio 2:1 (w/w %) demonstrated higher permeation efficacy...
MicroRNAs are known to be the important regulators of skin physiology and considered as new therapeutic targets treat diseases. In this study, miR-125b was identified a potent regulator steady-state melanogenesis. We found that expression inversely related pigment levels. A mimic decreased pigmentation-related gene melanin content, implying functions decrease pigmentation. Moreover, we observed reduction in pigmented cells at least partially due hypermethylation MIR125B-1 promoter, regulated...
Abstract The human cutaneous lymphatic system strictly controls functions by coordinating with skin cells. plays important roles in removing cell waste, residual proteins, various antigens, and immune cells from tissues to maintain homeostasis activate the through drainage of interstitial fluid 1,2 . protects our body external stimuli such as pathogens 3,4 Herein, develop an vitro model, we present two 3D microfluidic platforms: a lymphangiogenesis model precollecting vessel-like structure...
Skin provides the first defense line against environment while preserving physiological homeostasis. Subcutaneous tissues including fat depots that are important for maintaining skin structure and alleviating senescence altered during aging. This study investigated whether theaflavin (TF) in green tea (GT) has rejuvenation effects. Specifically, we examined high ratio of TF contents can induce subcutaneous adipogenesis supporting by modulating lipid metabolism. The co-fermented GT (CoF-GT)...
Adiponectin (APN), released mainly from adipose tissue, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity. A recent study showed that human hair follicles express APN receptors the presence of APN-mediated growth signaling, thereby suggesting potent growth-promoting adipokine. Previously, kojyl cinnamate ester derivatives (KCEDs) were synthesized in our institute as new anti-aging or adiponectin-/adipogenesis-inducing compounds. Here,...
Skin layers serve as a barrier against unexpected critical changes in the body due to environmental factors. Excessive ultraviolet (UV) B exposure increases levels of age-related factors, leading senescent cells and damaged skin tissues. Widely used dietary supplement, konjac (Amorphophallus konjac) glucomannan (KGM) has shown regeneration potential patch or sheet form with anti-inflammatory immunosuppressive effects. However, ability KGM reconstitute senescent/damaged following UV radiation...
Hair dermal papilla cells (hDPCs) play a crucial role in hair growth and regeneration, their function is influenced by nutrient oxygen supply. A microenvironment with significantly low (O
The characterization of melanoblasts is important for understanding their in vivo development, melanoma formation, and pigment-related disorders. However, no methods have been reported the isolation from human skin. Using a 'calcium-pulse' technique, involving differentiation keratinocytes with high calcium subsequent spontaneous separation epidermal sheets, we effectively isolated (keratinocyte-adapted melanoblasts, KaMBs) keratinocyte culture. KaMBs expressed early melanogenesis-related...
Abnormal adipogenesis regulation is accompanied by a variety of metabolic dysfunctions and disorders. Caveolae play an important role in the fat production, modulated caveolae-associated proteins (Cavin-1 to 4). Here, we investigated Cavin-3 lipogenesis adipocyte differentiation, as regulatory functions roles adipocytes are unknown. A knockdown/overexpression stable cell line was established, adipogenesis-related gene protein expression changes were real-time quantitative PCR Western blot...
The aim of this study was to improve the skin accumulation hydroxycitric acid by using ethosomes with nanosize. We fabricated nanosized ethosome for topical delivery hydrophilic and evaluated their physical properties furthermore cytotoxicity. As results, in cell-based experiments, use encapsulating extract reduced lipid droplet deposition differentiated adipocytes, which visualized Oil Red O staining assay also quantitatively measured a triglyceride assay. observed reduction occurred...
Abstract The human cutaneous lymphatic system strictly controls the functions as coordinating with skin cells. plays important roles in removing cell waste, residual proteins, various antigens, and immune cells from tissues order to maintain homeostasis activate system, through drainage of interstitial fluid 1,2 . protects our body external stimulates such pathogens 3,4 Herein, develop vitro model, we present two 3D microfluidic platforms: a lymphangiogenesis model pre-collecting vessel-like...