A5028123205- Hair Growth and Disorders
- Dermatologic Treatments and Research
- melanin and skin pigmentation
- Skin Protection and Aging
- Dermatology and Skin Diseases
- Nail Diseases and Treatments
- Wound Healing and Treatments
- Cancer and Skin Lesions
- RNA regulation and disease
- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Advancements in Transdermal Drug Delivery
- Mesenchymal stem cell research
- Genetic and rare skin diseases.
- Immune Cell Function and Interaction
- Advanced Adaptive Filtering Techniques
- Chemotherapy-related skin toxicity
- Dyeing and Modifying Textile Fibers
- Terahertz technology and applications
- Autoimmune and Inflammatory Disorders
- Speech and Audio Processing
- Nerve injury and regeneration
- Cutaneous lymphoproliferative disorders research
- Herpesvirus Infections and Treatments
- Nonmelanoma Skin Cancer Studies
Seoul National University
2016-2025
Seoul National University Hospital
2015-2024
Samsung (South Korea)
2024
Harvard University
2023
Ministry of Food and Drug Safety
2014-2020
Chung-Ang University Hospital
2010-2019
Kyung Hee University
2019
Seoul National University Bundang Hospital
2019
Kyung Hee University Medical Center
2019
Biomedical Research Institute
2018
Alopecia areata is an autoimmune condition characterized by rapid hair loss in the scalp, eyebrows, and eyelashes, for which treatments are limited. Baricitinib, oral, selective, reversible inhibitor of Janus kinases 1 2, may interrupt cytokine signaling implicated pathogenesis alopecia areata.We conducted two randomized, placebo-controlled, phase 3 trials (BRAVE-AA1 BRAVE-AA2) involving adults with severe a Severity Tool (SALT) score 50 or higher (range, 0 [no scalp loss] to 100 [complete...
The oral Janus kinase (JAK) inhibitor baricitinib has demonstrated efficacy for severe alopecia areata (AA) over 36 weeks. There are limited data on the longer-term treatment of AA.The aim this study was to evaluate and safety AA in adults with ≥50% scalp hair loss through 52 weeks continuous therapy two phase III trials (BRAVE-AA1 BRAVE-AA2).Patients randomized at baseline BRAVE-AA1 (N = 465) BRAVE-AA2 390) retained their allocation Week 52. Efficacy outcomes included proportion patients...
Abstract Background Female pattern hair loss ( FPHL ) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue‐derived stem cells ADSC s) and conditioned media of s ‐ CM are reported to promote growth vitro . However, there no clinical reports on the treatment alopecia using Objectives This study evaluates our experience use for Methods A retrospective, observational outcomes 27 patients with treated was performed. To evaluate efficacy treatment,...
This study examines the Environmental Kuznets Curve (EKC) hypothesis by adopting a country’s ecological footprint as an indicator of environmental degradation in three East Asian countries: Japan, Korea, and China. During development process, countries intend to balance between stabilizing export demand maintaining sustainable economic improvement context deteriorating global warming climate change. The (henceforth, EKC) was originally developed estimate correlation environment condition...
Abstract Dissolving microneedles (DMN) supplemented with therapeutic molecules have been developed to enhance transdermal delivery efficiency of topically applied drugs in a minimally invasive manner. However, the dose DMN system is limited owing low solubility drug. In fact, although triamcinolone acetonide (TA) one most widely prescribed for relieving atopic dermatitis (AD), its poor dissolving nature makes it difficult design and fabricate containing dosage TA. this study, TA suspension...
This subgroup analysis of the ALLEGRO phase 2b/3 trial (NCT03732807) evaluated efficacy and safety ritlecitinib, an oral, selective dual JAK3/TEC family kinase inhibitor, for treatment alopecia areata (AA) in patients aged 12-17 years.In ALLEGRO-2b/3, ≥12 years with AA ≥50% scalp hair loss received once-daily ritlecitinib 50 or 30 mg (±4-week 200-mg loading dose) 10 placebo 24 weeks. In a subsequent 24-week extension period, groups continued their doses, initially assigned to switched 200/50...
Abstract This subgroup analysis of the ALLEGRO phase 2b/3 study (NCT3732807) assessed efficacy and safety multiple doses ritlecitinib, an oral JAK3/TEC family kinase inhibitor, in Asian patients with alopecia areata (AA). Patients aged ≥12 years AA ≥50% scalp hair loss received once‐daily ritlecitinib 50 or 30 mg (with without 4‐week 200‐mg loading dose [“200/50” “200/30”]) 10 placebo for 24 weeks, followed by a 24‐week extension, which initially assigned to switched 200/50 mg. In this...
The peroxisome proliferator-activated receptors (PPARs) impart diverse cellular effects in biological systems. Because stellate cell activation during liver injury is associated with declining PPARγ expression, we hypothesized that its expression critical cell-mediated fibrogenesis. We therefore modulated vivo. was depleted rat livers by using an adenovirus-Cre recombinase system. overexpressed additional adenoviral vector (AdPPARγ). Bile duct ligation utilized to induce and fibrosis vivo;...
Purpose: The aim of this study is to estimate total sugar intake and identify major food sources in the diet Korean population. Methods: Dietary data 33,745 subjects aged one year over from KNHANES 2008-2011 were used analysis. Information on dietary was obtained by day 24-hour recall method KNHANES. A database for content foods reported established using Release 25 U.S. Department Agriculture National Nutrient Database Standard Reference, a Ministry Food Drug Safety, information nutrition...
The progression of androgenetic alopecia is closely related to androgen-inducible transforming growth factor (TGF)-<TEX>${\beta}1$</TEX> secretion by hair follicle dermal papilla cells (DPCs) in bald scalp. Physiological levels androgen exposure were reported increase reactive oxygen species (ROS) generation. In this study, rat vibrissae (DP-6) transfected with receptor showed increased ROS production following treatment. We confirmed that TGF-<TEX>${\beta}1$</TEX> treatment DP-6, whereas...
Abstract Chronic inflammatory skin diseases (CISDs) negatively impact a large number of patients. Injection triamcinolone acetonide (TA), an anti‐inflammatory steroid drug, directly into the dermis diseased using needle‐syringe systems is long‐established procedure for treating recalcitrant lichenified lesions CISDs, referred to as TA intralesional injection (TAILI). However, TAILI causes severe pain, causing patients be stressed and reluctant undergo treatment. Furthermore, practitioner...
Introduction High dietary sodium is a leading contributor to hypertension, and hypertension the underlying cause of death globally. There robust body evidence supporting health benefits reduction. Sodium intake in South Korea high, with about half population consuming > 4000 mg/day, twice recommended upper limit. Methods In 2012, implemented its National Plan Reduce Intake, goal reducing consumption by 20%, 3900 2020. The plan included five key components: (1) consumer awareness campaign...
Seborrheic keratoses (SKs) are common epidermal tumors in the white population over 40 years. The etiology of SKs is not well known; however, exposure to sunlight was suggested play a role development them. To our knowledge, no well-designed study has been undertaken order investigate clinical characteristics brown-skinned Korean population. aim this assess prevalence and features males possible relationship with sun risk factors developing SKs.A total consecutive 303 male volunteers, aged...