A5001752840- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Spatial Neglect and Hemispheric Dysfunction
- Optical Imaging and Spectroscopy Techniques
- T-cell and B-cell Immunology
- Neural dynamics and brain function
- Immune Response and Inflammation
- Neurological Disease Mechanisms and Treatments
- Skin and Cellular Biology Research
- Immune Cell Function and Interaction
- Hair Growth and Disorders
- Cerebrovascular and genetic disorders
- Wnt/β-catenin signaling in development and cancer
Brigham and Women's Hospital
2023-2024
Harvard University
2024
Circuit Therapeutics (United States)
2024
Beth Israel Deaconess Medical Center
2022-2023
Hadassah Medical Center
2023
Berenson Allen Center for Noninvasive Brain Stimulation
2022
Children's Hospital of Philadelphia
2015
University of Pennsylvania
2013
Objective Patients with Alzheimer's disease (AD) have diffuse brain atrophy, but some regions, such as the anterior cingulate cortex (ACC), are spared and may even show increase in size compared to controls. The extent, clinical significance, mechanisms associated increased cortical thickness AD remain unknown. Recent work suggested neural facilitation of regions anticorrelated atrophied frontotemporal dementia. Here, we aim determine whether occurs sporadic AD, it relates symptoms, occur...
Importance Drug-resistant temporal lobe epilepsy (TLE) has been associated with hippocampal pathology. Most surgical treatment strategies, including resection and responsive neurostimulation (RNS), focus on this disease epicenter; however, imaging alterations distant from the hippocampus, as well emerging data trials, suggest conceptualizing TLE a network disorder. Objective To assess whether brain networks connected to areas of atrophy in hippocampus align topography neuroimaging RNS...
Systemic inflammatory response syndrome describes a heterogeneous group of cytokine storm disorders, with different immunogens and cytokines leading to variations in organ pathology. The severe inflammation generated by the results widespread pathology including alterations T- B-lymphocyte counts. This study explores roles TLR9 IFN-γR stimulation decreasing B-cell lymphopoiesis mouse model hyperinflammation. We demonstrate that early is severely compromised during TLR9- IFN-γ-driven...
<title>Abstract</title> Transcranial magnetic stimulation (TMS) is effective for major depressive disorder (MDD) despite imprecise scalp-based targeting. Retrospective analyses suggest that targeting one brain circuit improves “dysphoric” symptoms, while a different “anxiosomatic” symptoms. Here, we tested this hypothesis prospectively. Individuals with moderate-to-severe MDD and anxiety (n=40) were randomized to receive TMS dysphoric (dorsolateral prefrontal cortex) or anxiosomatic...
<h3>Objective:</h3> Localize visuospatial dysfunction in Alzheimer's disease (AD) using atrophy and network mapping techniques, identify whether clock-draw or clock-copy is a better test of parietal lobe dysfunction. <h3>Background:</h3> Visuospatial AD common direct contributor to falls, car accidents loss independence. Better understanding allows for earlier intervention improved safety. Atrophy studies have localized multiple brain regions suggesting it maps network. Here, cortical...
Abstract Background Visuospatial dysfunction is the predominant symptom in ∼5% of patients with Alzheimer’s disease (AD) and common amnestic patients. If we can predict which are more likely to have trouble visuospatial functioning, intervene earlier prevent falls car accidents improve quality life. Method There were 184 subjects AD Disease Neuroimaging Initiative database MRI scans clock‐draw clock‐copy scores ranging from 1‐5. Atrophy was defined as thinner than expected compared age sex...
Abstract Background Visuospatial dysfunction is the predominant symptom in ∼5% of patients with Alzheimer’s disease (AD) and common amnestic patients. If we can predict which are more likely to have trouble visuospatial functioning, intervene earlier prevent falls car accidents improve quality life. Method There were 184 subjects AD Disease Neuroimaging Initiative database MRI scans clock‐draw clock‐copy scores ranging from 1‐5. Atrophy was defined as thinner than expected compared age sex...
Abstract Background Alzheimer’s disease (AD) is associated with neurophysiologic changes, including cortical hyperexcitability and reduced long‐term potentiation (LTP)‐like plasticity, that can be investigated using transcranial magnetic stimulation (TMS). AD preceded by a preclinical phase of beta‐amyloid accumulation without clinical or cognitive symptoms. Our goal to test the relationship TMS‐based markers against established MRI‐based measures AD. If changes precede manifestation AD,...