A5033406884- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Neurodegenerative Diseases
- Sex and Gender in Healthcare
- Advanced MRI Techniques and Applications
- Pharmaceutical industry and healthcare
- Solar and Space Plasma Dynamics
- Neural dynamics and brain function
- Ionosphere and magnetosphere dynamics
- Advanced Memory and Neural Computing
- Medical and Biological Sciences
- Astro and Planetary Science
Montreal Neurological Institute and Hospital
2023-2025
McGill University
2023-2025
United States Naval Research Laboratory
2006
Network neuroscience offers a unique framework to understand the organizational principles of human brain. Despite recent progress, our understanding how brain is modulated by focal lesions remains incomplete. Resection temporal lobe most effective treatment control seizures in pharmaco-resistant epilepsy (TLE), making this syndrome powerful model study lesional effects on network organization young and middle-aged adults. Here, we assessed downstream consequences lesion its surgical...
Importance Drug-resistant temporal lobe epilepsy (TLE) has been associated with hippocampal pathology. Most surgical treatment strategies, including resection and responsive neurostimulation (RNS), focus on this disease epicenter; however, imaging alterations distant from the hippocampus, as well emerging data trials, suggest conceptualizing TLE a network disorder. Objective To assess whether brain networks connected to areas of atrophy in hippocampus align topography neuroimaging RNS...
Abstract Excitation‐inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with ample research focusing on elucidating its cellular manifestations. However, few studies investigate E/I at macroscale, whole‐brain level, and microcircuit‐level mechanisms clinical significance remain incompletely understood. Here, Hurst exponent, an index ratio, computed from resting‐state fMRI time series, microcircuit parameters are simulated using biophysical models. A...
Temporal lobe epilepsy (TLE) presents with substantial inter-patient variability in clinical and neuroimaging manifestations. This multicenter study examined inter-individual differences spatial patterns of intrinsic brain function TLE using normative modeling at multiple scales evaluated the effectiveness individual functional deviations for diagnosis postsurgical outcome prediction. We analyzed multimodal MRI data on 298 healthy controls, 282 patients, 45 disease controls extratemporal...
Temporal lobe epilepsy (TLE), the most common pharmaco-resistant in adults, has been linked to structural brain changes extending beyond mesiotemporal areas. While not traditionally viewed as a neurodegenerative disorder, recent ex-vivo studies have shown elevated levels of misfolded tau protein TLE. This study investigated deposition TLE patients using in-vivo PET tracer [18F]MK-6240. 18 and 20 healthy controls underwent imaging, with data analyzed assess uptake its relationship...
ABSTRACT Objectives Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey white matter structures. Evidence supports a progressive condition although the temporal evolution TLE poorly defined. This ENIGMA-Epilepsy study utilized multimodal magnetic resonance imaging (MRI) data to investigate structural in patients across adult lifespan. We charted both changes explored covariance age-related compartments. Methods studied 769 885...
A bstract Excitation-inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with mounting body previous research focusing on elucidating its cellular manifestations. However, there are limited studies into E/I at macroscale and microcircuit-level mechanisms clinical associations. In our current work, we computed Hurst exponent—a previously validated index ratio—from resting-state fMRI time series, simulated microcircuit parameters using biophysical...
Abstract Network neuroscience offers a unique framework to understand the organizational principles of human brain. Despite recent progress, our understanding how brain is modulated by focal lesions remains incomplete. Resection temporal lobe most effective treatment control seizures in pharmaco-resistant epilepsy (TLE), making this syndrome powerful model study lesional effects on network organization young and middle-aged adults. Here, we assessed downstream consequences lesion its...
ABSTRACT INTRODUCTION Epilepsy is increasingly conceptualized as a network disorder, and advancing methods for its diagnosis treatment requires characterizing both the epileptic generator related networks. We combined multimodal magnetic resonance imaging (MRI) high-density electroencephalography (HD-EEG) to interrogate alterations in cortical microstructure, morphology, intrinsic local function within beyond spiking tissue focal epilepsy. METHODS studied 25 patients with epilepsy (12F, mean...
Language plays an important role in ensuring gender inclusivity within neurology. Despite progress language inclusivity, such as the emergence of explicit pronouns, more remains to be done. Historically, sex and have been used interchangeably, but they are, fact, distinct concepts. This is distinction particularly care transgender diverse (TGD) individuals, whose assigned are incongruent. In health setting, TGD individuals frequently report misgendering, identity invalidation, pathologizing,...