Barbara A. K. Kreilkamp
A5054679997- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Diet and metabolism studies
- Neonatal and fetal brain pathology
- Neurological disorders and treatments
- Genetics and Neurodevelopmental Disorders
- Cerebrospinal fluid and hydrocephalus
- Psychology of Moral and Emotional Judgment
- EEG and Brain-Computer Interfaces
- Genomics and Rare Diseases
- Genomic variations and chromosomal abnormalities
- Radiomics and Machine Learning in Medical Imaging
- Free Will and Agency
- Glioma Diagnosis and Treatment
- Brain Tumor Detection and Classification
- Metabolism and Genetic Disorders
- RNA regulation and disease
- Medical Image Segmentation Techniques
- Emotions and Moral Behavior
University of Göttingen
2021-2024
University of Liverpool
2015-2023
Walton Centre
2016-2023
Universitätsmedizin Göttingen
2021-2023
King's College London
2021
University of Trento
2015
Osnabrück University
2014
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging common epilepsy syndromes, including temporal lobe epilepsy, extratemporal and genetic generalized epilepsy. Our goal was rank the most robust matter microstructural differences across within syndromes multicentre sample adult patients. Diffusion-weighted MRI were analysed from...
There are competing explanations for persistent postoperative seizures after temporal lobe surgery. One is that 1 or more particular subtypes of mesial epilepsy (mTLE) exist particularly resistant to We sought identify a common brain structural and connectivity alteration in patients with using preoperative quantitative magnetic resonance imaging diffusion tensor (DTI).We performed series studies 87 mTLE (47 subsequently rendered seizure free, 40 who continued experience seizures) 80 healthy...
Approximately one in every two patients with pharmacoresistant temporal lobe epilepsy will not be rendered completely seizure-free after surgery. The reasons for this are unknown and likely to multifactorial. Quantitative volumetric magnetic resonance imaging techniques have provided limited insight into the causes of persistent postoperative seizures epilepsy. relationship between outcome preoperative pathology white matter tracts, which constitute crucial components epileptogenic networks,...
Abstract Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients epilepsy related findings to postmortem gene expression patterns. Brain analysis included 578 adults temporal lobe (TLE), 288 idiopathic generalized (IGE), 1328 healthy controls from 18 centres...
Artificial intelligence has recently gained popularity across different medical fields to aid in the detection of diseases based on pathology samples or imaging findings. Brain magnetic resonance (MRI) is a key assessment tool for patients with temporal lobe epilepsy (TLE). The role machine learning and artificial increase brain abnormalities TLE remains inconclusive. We used support vector (SV) deep (DL) models region interest (ROI-based) structural (n = 336) diffusion 863) MRI data from...
Temporal lobe epilepsy, a common drug-resistant epilepsy in adults, is primarily limbic network disorder associated with predominant unilateral hippocampal pathology. Structural MRI has provided an vivo window into whole-brain grey matter structural alterations temporal relative to controls, by either mapping (i) atypical inter-hemispheric asymmetry; or (ii) regional atrophy. However, similarities and differences of both asymmetry atrophy measures have not been systematically investigated....
A detailed understanding of white matter tract alterations in patients with temporal lobe epilepsy (TLE) is important as it may provide useful information for likely side seizure onset, cognitive impairment and postoperative prognosis. However, most diffusion-tensor imaging (DTI) studies have relied on manual reconstruction bundles, despite the recent development automated techniques. In present study, we used an tractography analysis approach to quantify TLE determine relationships between...
Recent work has shown that people with common epilepsies have characteristic patterns of cortical thinning, and these changes may be progressive over time. Leveraging a large multicenter cross-sectional cohort, we investigated whether regional morphometric occur in sequential manner, mesial temporal lobe epilepsy hippocampal sclerosis (MTLE-HS) correlate clinical features. We extracted measures thickness, surface area, subcortical brain volumes from T1-weighted (T1W) magnetic resonance...
Despite an expanding literature on brain alterations in patients with longstanding epilepsy, few neuroimaging studies investigate newly diagnosed focal epilepsy (NDfE). Understanding network impairments at diagnosis is necessary to elucidate whether or not abnormalities are principally due the chronicity of disorder and develop prognostic markers treatment outcome. Most adults NDfE do have MRI-identifiable lesions reasons for seizure onset refractoriness unknown. We applied structural...
Abstract It is well established that abnormal thalamocortical systems play an important role in the generation and maintenance of primary generalised seizures. However, it currently unknown which thalamic nuclei how nuclear‐specific functional connectivity are differentially impacted patients with medically refractory non‐refractory idiopathic epilepsy (IGE). In present study, we performed structural resting‐state magnetic resonance imaging (MRI) IGE, segmented thalamus into constituent...
A bstract Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) is associated a complex genetic architecture, but the translation from risk factors to brain vulnerability remains unclear. Here, we examined associations between epilepsy-related polygenic scores for HS (PRS-HS) and structure in large sample of neurotypical children, correlated these signatures case-control findings multicentric cohorts patients TLE-HS. Imaging-genetic analyses revealed PRS-related cortical thinning...
To investigate the agreement between manually and automatically generated tracts from diffusion tensor imaging (DTI) in patients with temporal lobe epilepsy (TLE). Whole along-the-tract diffusivity metrics correlations patient clinical characteristics were analyzed respect to tractography approach. We recruited 40 healthy controls 24 TLE who underwent conventional T1-weighted 60-direction DTI. An automated (Automated Fiber Quantification, AFQ) manual (TrackVis) deterministic approach was...
Abstract Despite an increasing number of drug treatment options for people with idiopathic generalized epilepsy (IGE), resistance remains a significant issue and the mechanisms underlying it remain poorly understood. Previous studies have largely focused on potential cellular or genetic explanations resistance. However, is understood to be network disorder there growing body literature suggesting altered topology large-scale resting networks in compared controls. We hypothesize that...
Objective To investigate the clinical and surgical outcome correlates of preoperative hippocampal subfield volumes in patients with refractory temporal lobe epilepsy (TLE) using a new magnetic resonance imaging (MRI) multisequence segmentation technique. Methods We recruited 106 TLE sclerosis (HS) who underwent conventional T1-weighted T2 short TI inversion recovery MRI. An automated algorithm was used to identify twelve subfields each hippocampus. A total 76 amygdalohippocampectomy...
Introduction: Idiopathic generalized epilepsy (IGE) is a collection of nonlesional epileptic network disorders. Around 20–40% patients with IGE are refractory to antiseizure medication, and mechanisms underlying refractoriness poorly understood. Here, we characterize structural brain alterations determine whether differ between nonrefractory IGE. Methods: Thirty-three (10 23 refractory) 39 age- sex-matched healthy controls were studied. Network nodes segmented from T1-weighted images, while...
Abstract Multicompartment diffusion magnetic resonance imaging (MRI) approaches are increasingly being applied to estimate intra‐axonal and extra‐axonal characteristics in the human brain. Fiber ball (FBI) its extension fiber white matter modeling (FBWM) such recently described multicompartment approaches. However, these particular have yet be clinical cohorts. The of several parameters with interpretable biological meaning may offer development new, noninvasive biomarkers pharmacoresistance...
Background and purpose Patients with chronic focal epilepsy may have atrophy of brain structures important for the generation maintenance seizures. However, little research has been conducted in patients newly diagnosed (NDfE), despite it being a crucial point time understanding underlying biology disorder. We aimed to determine whether NDfE show evidence volumetric abnormalities subcortical structures. Methods Eighty‐two 40 healthy controls underwent magnetic resonance imaging scanning...
Purpose To evaluate how retrospective head motion correction strategies affect the estimation of scalar metrics commonly used in clinical diffusion tensor imaging (DTI) studies along with their across-session reproducibility errors. Materials and Methods Fractional anisotropy (FA), mean diffusivity (MD), radial (RD), axial (AD) respective errors were measured on a 4T test–retest dataset healthy participants using five processing pipelines. These differed in: 1) number b0 volumes for...
Genetic generalized epilepsy (GGE) is the most common form of epilepsy. Although individual patients with GGE typically present without structural alterations, group differences have been demonstrated in and some subtypes like juvenile myoclonic (GGE-JME). Previous studies usually involved only small cohorts from single centers therefore could not assess imaging markers multiple subtypes. We performed a diffusion MRI mega-analysis 192 participants consisting 126 controls 66 four different...
To evaluate whether a dedicated epilepsy research protocol with expert image re-evaluation can increase identification of patients lesions and to attempt ascertain the potential reasons why were not identified previously on earlier clinical magnetic resonance imaging (MRI).Forty-three (26 female) focal refractory who had failed at least two trials anti-epileptic drug treatments studied. Patients recruited prospectively into study if previous MRI was deemed be "non-lesional" by clinicians...
ABSTRACT Objectives Temporal lobe epilepsy (TLE) is commonly associated with mesiotemporal pathology and widespread alterations of grey white matter structures. Evidence supports a progressive condition although the temporal evolution TLE poorly defined. This ENIGMA-Epilepsy study utilized multimodal magnetic resonance imaging (MRI) data to investigate structural in patients across adult lifespan. We charted both changes explored covariance age-related compartments. Methods studied 769 885...
Abstract Image templates are a common tool for neuroscience research. Often, they used spatial normalization of magnetic resonance imaging (MRI) data, which is necessary procedure analyzing brain morphology and function via voxel-based analysis. This allows the researcher to reduce individual shape differences across images make inferences multiple subjects. Many have small field-of-view typically focussed on brain, limiting use applications requiring detailed information about other...