A5019109627- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Prenatal Screening and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Fetal and Pediatric Neurological Disorders
- Psychosomatic Disorders and Their Treatments
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Neurology and Historical Studies
- Genetics and Neurodevelopmental Disorders
- Cerebrospinal fluid and hydrocephalus
- Trauma and Emergency Care Studies
- Pain Mechanisms and Treatments
- Peripheral Neuropathies and Disorders
- Paranormal Experiences and Beliefs
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
Atkins (United States)
2022-2023
King's College London
2016-2023
Minnesota Epilepsy Group
2023
St. George's University
2022
Keskuslaboratorio
2022
St George's, University of London
2018-2022
Atkins (United Kingdom)
2022
St George’s University Hospitals NHS Foundation Trust
2020-2022
St George's Hospital
2022
University of Liverpool
2015-2017
The fetal brain shows accelerated growth in the latter half of gestation, and these changes can be captured by 2D 3D biometry measurements. aim this study was to quantify normal fetuses using Magnetic Resonance Imaging (MRI) produce reference data a freely available centile calculator ( https://www.developingbrain.co.uk/fetalcentiles/ ). A total 127 MRI examinations (1.5 T) with appearance (21–38 gestational weeks) were included study. biometric parameters measured from slice-to-volume...
There are competing explanations for persistent postoperative seizures after temporal lobe surgery. One is that 1 or more particular subtypes of mesial epilepsy (mTLE) exist particularly resistant to We sought identify a common brain structural and connectivity alteration in patients with using preoperative quantitative magnetic resonance imaging diffusion tensor (DTI).We performed series studies 87 mTLE (47 subsequently rendered seizure free, 40 who continued experience seizures) 80 healthy...
Mild cerebral ventricular enlargement is associated with schizophrenia, autism, epilepsy, and attention-deficit/hyperactivity disorder. Fetal ventriculomegaly the most common central nervous system (CNS) abnormality affecting 1% of fetuses cognitive, language, behavioral impairments in childhood. Neurodevelopmental outcome partially predictable by 2-dimensional size ventricles absence other abnormalities. We hypothesized that isolated fetal a marker altered brain development characterized...
Background Patients with functional seizures (FS) can experience dissociation (depersonalisation) before their seizures. Depersonalisation reflects disembodiment, which may be related to changes in interoceptive processing. The heartbeat-evoked potential (HEP) is an electroencephalogram (EEG) marker of Aim To assess whether alterations processing indexed by HEP occur prior FS and compare this epileptic (ES). Methods amplitudes were calculated from EEG during video-EEG monitoring 25 patients...
Objective To investigate the clinical and surgical outcome correlates of preoperative hippocampal subfield volumes in patients with refractory temporal lobe epilepsy (TLE) using a new magnetic resonance imaging (MRI) multisequence segmentation technique. Methods We recruited 106 TLE sclerosis (HS) who underwent conventional T1-weighted T2 short TI inversion recovery MRI. An automated algorithm was used to identify twelve subfields each hippocampus. A total 76 amygdalohippocampectomy...
Background and purpose Patients with chronic focal epilepsy may have atrophy of brain structures important for the generation maintenance seizures. However, little research has been conducted in patients newly diagnosed (NDfE), despite it being a crucial point time understanding underlying biology disorder. We aimed to determine whether NDfE show evidence volumetric abnormalities subcortical structures. Methods Eighty‐two 40 healthy controls underwent magnetic resonance imaging scanning...
Semi-quantitative analysis of hippocampal internal architecture (HIA) on MRI has been shown to be a reliable predictor the side seizure onset in patients with temporal lobe epilepsy (TLE). In present study, we investigated relationship between postoperative outcome and preoperative semi-quantitative measures HIA.We determined HIA high in-plane resolution T2 short tau inversion recovery MR images 79 presumed unilateral mesial TLE (mTLE) due sclerosis (HS) who underwent amygdalohippocampectomy...
<h3></h3> Studies of newly-diagnosed epilepsy (NDE) will provide important insight into the underlying neurobiology in early stages and development imaging biomarkers for seizure cognitive outcomes. However, patients with NDE are rarely studied using techniques. This study investigated whether volumetric changes subcortical nuclei present newly diagnosed focal (NDfE). 101 NDfE 40 healthy controls received T1-weighted MRI. Quantitative MRI volume measurements thalamus, caudate nucleus putamen...
Objectives/Aims Patients with functional seizures (FS) can experience dissociation (depersonalisation) before their seizures. Depersonalisation encompasses a feeling of disembodiment, putatively caused by reduced afferent visceral mapping, that is, changes in interoceptive processing. The heartbeat-evoked potential (HEP) is an electroencephalographic (EEG) index synchronised neural responses to individual heartbeats, and marker representation. HEP amplitude reported be patients...
Introduction It is unknown why over one-third of patients with mesial temporal lobe epilepsy (mTLE) and hippocampal sclerosis (HS) continue to experience seizures despite surgery. We investigated the relationship between internal architecture (HIA) on preoperative MRI, postoperative seizure outcome in refractory mTLE HS. Methods HIA was assessed T2-STIR MR images using a published scoring system1 for 79 undergoing evaluation at University Hospital Bonn, Germany. Patients underwent...
<h3>Background</h3> Transverse myelitis (TM) associated with neuromyelitis optica (NMO) has many unusual characteristics compared TM in Multiple Sclerosis (MS): long centrally located lesions that cause significant motor-sensory (including tonic spasms) and autonomic dysfunction. We wish to report a symptom not previously described neurological literature, neuropathic post ejaculatory pain (PEP). <h3>Methods</h3> will present videos of 3 male patients AQP4-IgG +ve NMO describing...
Background Interoception describes the predictive representation and control of internal physiological state body. Disturbances in interoception have been demonstrated people with functional seizures. Little is known about epilepsy. Aim To compare dimensions across three groups - non-epileptic seizures (FS), epileptic (ES) healthy controls (HC). We hypothesised that ES would display deficits compared to HC, given neuroanatomical correlates are frequently implicated Methods included 37...
Abstract Background Patients with chronic focal epilepsy may have atrophy of brain structures important for the generation and maintenance seizures. However, little research has been conducted in patients newly diagnosed (NDfE), despite it being a crucial point time understanding underlying biology disorder. We aimed to determine whether NDfE show evidence volumetric abnormalities subcortical structures. Methods Eighty-two 40 healthy controls underwent MRI scanning using standard clinical...
Background Head Injury (HI) is a common presentation to the Emergency Department (ED). Most injuries are mild and patients often discharged directly from ED. However, persistent symptoms failure return-to-work common. Comprehensive advice clear pathway if persist critical prevent unnecessary morbidity. Objectives To audit discharge follow-up of an ED with HI. Methodology A Data Collection Tool was used guidance given attending St George’s Hospital in December 2018 audited against NICE...
Background Patients with functional seizures (FS) can experience dissociation (depersonalisation) before their seizures. Depersonalisation encompasses a feeling of disembodiment, putatively caused by reduced afferent visceral mapping, that is, changes in interoceptive processing. The heartbeat-evoked potential (HEP) is an electroencephalographic (EEG) index synchronised neural responses to individual heart- beats, and marker representation. HEP amplitude reported be dep-...