A5081422845- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Head and Neck Cancer Studies
- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- Nausea and vomiting management
- Anesthesia and Pain Management
- Memory and Neural Mechanisms
- Cervical and Thoracic Myelopathy
- Machine Learning in Bioinformatics
- Spine and Intervertebral Disc Pathology
- Radiomics and Machine Learning in Medical Imaging
- Autism Spectrum Disorder Research
- Pathogenesis and Treatment of Hiccups
- Advanced Memory and Neural Computing
- Mental Health Research Topics
- Spatial Neglect and Hemispheric Dysfunction
- Chronic Lymphocytic Leukemia Research
- Neonatal and fetal brain pathology
- Genetic Neurodegenerative Diseases
Montreal Neurological Institute and Hospital
2022-2025
McGill University
2022-2025
University of British Columbia
2024
Montreal Children's Hospital
2024
University of Electronic Science and Technology of China
2020-2022
Fourth People's Hospital of Sichuan Province
2012-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2012
Abstract Objective Temporal lobe epilepsy (TLE) is the most common pharmacoresistant in adults. Here we profiled local neural function TLE vivo , building on prior evidence that has identified widespread structural alterations. Using resting‐state functional magnetic resonance imaging (rs‐fMRI), mapped whole‐brain intrinsic timescales (INT), which reflect temporal hierarchies of processing. Parallel analysis and diffusion MRI data examined associations with TLE‐related compromise. Finally,...
Abstract The study of large-scale brain connectivity is increasingly adopting unsupervised approaches that derive low-dimensional spatial representations from high-dimensional connectomes, referred to as gradient analysis. When translating this approach interindividual variations in connectivity, one technical issue pertains the selection an appropriate group-level template which individual gradients are aligned. Here, we compared different construction strategies using functional and...
Importance Drug-resistant temporal lobe epilepsy (TLE) has been associated with hippocampal pathology. Most surgical treatment strategies, including resection and responsive neurostimulation (RNS), focus on this disease epicenter; however, imaging alterations distant from the hippocampus, as well emerging data trials, suggest conceptualizing TLE a network disorder. Objective To assess whether brain networks connected to areas of atrophy in hippocampus align topography neuroimaging RNS...
Abstract Excitation‐inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with ample research focusing on elucidating its cellular manifestations. However, few studies investigate E/I at macroscale, whole‐brain level, and microcircuit‐level mechanisms clinical significance remain incompletely understood. Here, Hurst exponent, an index ratio, computed from resting‐state fMRI time series, microcircuit parameters are simulated using biophysical models. A...
Temporal lobe epilepsy (TLE) presents with substantial inter-patient variability in clinical and neuroimaging manifestations. This multicenter study examined inter-individual differences spatial patterns of intrinsic brain function TLE using normative modeling at multiple scales evaluated the effectiveness individual functional deviations for diagnosis postsurgical outcome prediction. We analyzed multimodal MRI data on 298 healthy controls, 282 patients, 45 disease controls extratemporal...
Neuroimaging studies in patients with temporal lobe epilepsy (TLE) show widespread brain network alterations beyond the mesiotemporal lobe. Despite critical role of cerebrovascular system maintaining whole-brain structure and function, changes cerebral blood flow (CBF) remain incompletely understood disease. Here, we studied perfusion vascular TLE assessed its associations gray white matter compromises various clinical variables.
Symptomatic adjacent segment disease (ASD) after anterior cervical fusion (ACF) is reported in 25% of patients at 10 years postoperatively. Debate continues as to whether this degeneration due the natural history disk or changed biomechanics ACF. This study explored congenital stenosis predisposes an increased incidence ASD A retrospective review 635 with myelopathy radiculopathy was performed; 364 had complete records for review. Patients underwent 1- 5-level ACF (94 one-level, 145...
Temporal lobe epilepsy (TLE) is one of the most common pharmaco-resistant epilepsies in adults. While hippocampal pathology hallmark this condition, emerging evidence indicates that brain alterations extend beyond mesiotemporal epicenter and affect macroscale function cognition. We studied functional reorganization TLE, explored structural substrates, examined cognitive associations. investigated a multisite cohort 95 patients with TLE healthy controls using state-of-the-art multimodal 3T...
Abstract Declarative memory encompasses episodic and semantic divisions. Episodic captures singular events with specific spatiotemporal relationships, whereas houses context-independent knowledge. Behavioural functional neuroimaging studies have revealed common distinct neural substrates of both systems, implicating mesiotemporal lobe (MTL) regions such as the hippocampus distributed neocortices. Here, we explored declarative system reorganization in patients unilateral temporal epilepsy...
A bstract Declarative memory encompasses episodic and semantic divisions. Episodic captures singular events with specific spatiotemporal relationships, while houses context-independent knowledge. Behavioral functional neuroimaging studies have revealed common distinct neural substrates of both systems, implicating mesiotemporal lobe (MTL) regions distributed neocortices. Here, we studied a population patients unilateral temporal epilepsy (TLE) variable degrees MTL pathology as human disease...
Distractor suppression (DS) is crucial in goal-oriented behaviors, referring to the ability suppress irrelevant information. Current evidence points prefrontal cortex as an origin region of DS, while subcortical, occipital, and temporal regions are also implicated. The present study aimed examine contribution communications between these brain visual DS. To do it, we recruited two independent cohorts participants for study. One cohort participated a search experiment where salient distractor...
A bstract Excitation-inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with mounting body previous research focusing on elucidating its cellular manifestations. However, there are limited studies into E/I at macroscale and microcircuit-level mechanisms clinical associations. In our current work, we computed Hurst exponent—a previously validated index ratio—from resting-state fMRI time series, simulated microcircuit parameters using biophysical...
Selective attention, the ability to filter relevant from a sea of sensory information, relies on prioritization goal-relevant information (target facilitation) and suppression goal-irrelevant (distractor suppression). Although several lines evidence have shown that target facilitation distractor were mediated by distinct mechanisms, underlying neural substrates remain unclear. To address this question, we acquired structural resting-state magnetic resonance imaging scans, as well behavioral...
Aims: To determine the antiemetic efficacy of a 6-day aprepitant schedule in patients receiving multiple-day cisplatin. Patients & methods: diagnosed with lung cancer and who were chemotherapy-naive screened. The willing to use randomly divided into two groups: prolonged (PA; aprepitant) standard (SA; 3-day aprepitant); rejected recruited control group (group C). Primary end points included safety number days without chemotherapy-induced nausea vomiting. Results: There was no statistical...
A bstract O bjective Neuroimaging has been the prevailing method to study brain networks in temporal lobe epilepsy (TLE), showing widespread alterations beyond mesiotemporal lobe. Despite critical role of cerebrovascular system maintaining whole-brain structure and function, changes cerebral blood flow (CBF) remain incompletely understood disease. M ethods We studied 24 individuals with pharmaco-resistant TLE 38 healthy adults using multimodal 3T magnetic resonance imaging. compared regional...
The previous neuroimaging functional connectivity analyses have indicated that the association between inferior frontal gyrus (IFG) and other brain regions results in better emotion regulation reappraisal tasks. However, no study has explored relationship IFG-based resting-state (rsFC) dispositional use of strategy. Therefore, present examined potential associations rsFC patterns both left right IFG use. One hundred healthy participants completed Emotion Regulation Questionnaire (ERQ)...
Salient stimuli can capture attention in a bottom-up manner; however, this attentional be suppressed top-down manner. It has been shown that individuals with high working memory capacity (WMC) suppress salient‑but-irrelevant distractors better than those low WMC; neural substrates underlying difference remain unclear. To examine this, participants or WMC (high-/low-WMC, n = 44/44) performed visual search task wherein color singleton item served as salient distractor, and underwent structural...
Synchronous multiple primary cancers are relatively uncommon and synchronous in coexistence with dermatomyositis (DM) extremely rare. In the present study, we report a case of 64-year-old male nasopharyngeal undifferentiated non-keratinizing carcinoma cardia adenocarcinoma which were diagnosed synchronously. addition, suspected DM was during course chemotherapy. The symptoms exaggerated even when methylprednisolone while administered. patient succumbed to nutritional deterioration four...
ABSTRACT Autism spectrum disorder (ASD) is a prevalent and highly heterogeneous neurodevelopmental disorder. Previous studies have attempted to identify ASD subgroups by analyzing isolated cortical structural features. However, these not considered the relationship between multiple features, which provide information on organization of brain. Morphometric similarity network (MSN), brain contributed anatomical features (gray matter volume, mean thickness, surface area, curvature, Gaussian...
ABSTRACT INTRODUCTION Epilepsy is increasingly conceptualized as a network disorder, and advancing methods for its diagnosis treatment requires characterizing both the epileptic generator related networks. We combined multimodal magnetic resonance imaging (MRI) high-density electroencephalography (HD-EEG) to interrogate alterations in cortical microstructure, morphology, intrinsic local function within beyond spiking tissue focal epilepsy. METHODS studied 25 patients with epilepsy (12F, mean...
Visual selective attention allows us to filter relevant inputs from irrelevant during visual processing. In contrast rich research exploring how the brain facilitates task-relevant inputs, less is known about suppresses inputs. this study, we used transcranial magnetic stimulation (TMS) investigate causal role of right dorsolateral prefrontal cortex (DLPFC), a crucial area for attentional control, in distractor suppression. Specifically, 10-Hz repetitive TMS (rTMS) was applied DLPFC and...
Objective To evaluate the efficacy and toxicity of docetaxel combined with nedaplatin or cisplatin in treatment patients advanced head neck carcinoma.Methods 58 carcinoma were enrolled into study.These divided group (27 patients:docetaxel 75mg/m2 on day 1 80mg/m2 21-day cycle) cisplantin group( 31 25mg/m2 1-3 cycle).Each patient should complete two cycle.Results The response rate was 59.2％ 54.8％,the difference statistically significant between groups( P ＞ 0.05 ).The white blood cell plate...