A5100780212- Microbial Natural Products and Biosynthesis
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Chemical Synthesis and Analysis
- Biochemical and Structural Characterization
- Point processes and geometric inequalities
- Fungal Biology and Applications
- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Advanced Proteomics Techniques and Applications
- Carbohydrate Chemistry and Synthesis
- Mathematical Approximation and Integration
- Metabolomics and Mass Spectrometry Studies
- Soil, Finite Element Methods
- Ionosphere and magnetosphere dynamics
- Marine Sponges and Natural Products
- Immune cells in cancer
- Soil and Environmental Studies
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- Actinomycetales infections and treatment
- Particle accelerators and beam dynamics
- Studies on Chitinases and Chitosanases
- Land Use and Ecosystem Services
- Metabolism and Genetic Disorders
Dalian University of Technology
2012-2024
Southern Medical University
2024
Tianjin Medical University
2023
East China Normal University
2013-2023
Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine
2022
Hainan Normal University
2021-2022
National Central University
2022
Guangzhou Medical University
2022
Guangzhou First People's Hospital
2022
Macau University of Science and Technology
2022
Abstract Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, cellular specificity sensitivity stress on brain epitranscriptomics its impact remain unclear. Here, we found ALKBH5, an RNA demethylase N6-methyladenosine (m6A), was increased in MDD patients’ blood models. ALKBH5 astrocytes more sensitive than neurons endothelial cells. Selective deletion astrocytes, but not cells, produced...
Marine actinobacteria are potential producers of various secondary metabolites with diverse bioactivities. Among bioactive compounds, anti-complement agents have received great interest for drug discovery to treat numerous diseases caused by inappropriate activation the human complement system. However, marine streptomycetes producing still poorly explored. In this study, a marine-derived strain Streptomyces sp. DUT11 showing superior activity was focused, and its genome sequence analyzed....
Proteomic characterization of plasma is critical for the development novel pharmacodynamic biomarkers. However, vast dynamic range renders profiling proteomes extremely challenging. Here, we synthesized zeolite NaY and developed a simple rapid method to achieve comprehensive deep proteome using protein corona formed on NaY. Specifically, were co-incubated form (NaY-PPC), followed by conventional identification liquid chromatography-tandem mass spectrometry. was able significantly enhance...
A new isocoumarin, penicimarin N (1), along with five known compounds (2-6), were isolated from the mangrove-derived fungus Penicillium sp. TGM112. The structure of 1 was elucidated on basis extensive spectroscopic data analysis, and absolute configuration determined by comparison their circular dichroism (CD) spectra literature. structures literature data. All examined for antioxidant α-glucosidase activities. Compound showed strong activity IC50 value 1.0 mM, also exhibited moderate...
Marine-derived actinobacteria are rich sources of valuable natural products and industrial enzymes for biotechnology applications. The marine-derived Streptomyces sulphureus strain L180 was isolated from the marine sediment in a sea cucumber farm at depth about 10 m Dalian, China, its 16S rRNA gene sequence determined to have highest identity that NRRL B-1627(T) (99.65%). Here, we report draft genome this strain.
Marine streptomycetes are rich sources of natural products with novel structures and interesting biological activities, genome mining marine facilitates rapid discovery their useful products. In this study, a marine-derived Streptomyces sp. M10 was revealed to share 99.02% 16S rDNA sequence identity that marokkonensis Ap1T, thus named S. M10. To further evaluate its biosynthetic potential, the 7,207,169 bps sequenced. Genomic analysis for potential secondary metabolite-associated gene...
Overexpression of SARPs enhanced FK506 production in <italic>Streptomyces</italic> sp. KCCM1116P. The endogenous improved titer, whereas the exogenous SARP productivity at early fermentation stage.
Abstract We previously reported the results of a phase II trial anti‐PD‐1 antibody plus anti‐vascular endothelial growth factor receptor 2 inhibitors and eribulin in heavily pretreated advanced triple‐negative breast cancer with favorable objective response rate (ORR) 37.0% (NCT04303741). Here we report updated survival outcomes serum metabolite changes study. Proton nuclear magnetic resonance spectroscopy was used to detect dynamics explore biomarkers for response. found that...
Genome sequences of marine streptomycetes are valuable for the discovery useful enzymes and bioactive compounds by genome mining. However, publicly available complete still limited. Here, we present sequence a streptomycete Streptomyces sp. S063 CGMCC 14582. Species delineation based on pairwise digital DNA-DNA hybridization comparison ANI (average nucleotide identity) value showed that 14582 possesses unique is clearly different from all other genomes. Bioactivity tests produces metabolites...
Talaromyces marneffei ( T. ) is one of the most important opportunistic human pathogens endemic in Southeast Asia. Talaromycosis, which was once regarded as an infectious disease patients with acquired immunodeficiency syndrome, being increasingly reported HIV-negative populations. Since infection can be localized or disseminated, may present a variety symptoms. However, mediastinal attributed to extremely rare. We report case 32-year-old female who manifested large mass and eventually...
Abstract Current ecological restoration techniques often face challenges on steep and hard surfaces (e.g., concrete or rock surfaces) because of their reliance soil as a vegetation substrate. Two geosynthetic-based are proposed in which geosynthetic material is used to replace the substrate hard-surface slopes. In first technique, planted directly (GVS), where GVS provides water room for growth roots. second Hygrophila ringens GVS. This plant exhibits rapid initially then dies after three...
Abstract Current ecological restoration techniques often face challenges on steep and hard surfaces (e.g., concrete or rock surfaces) because of their reliance soil as a vegetation substrate. Two geosynthetic-based were proposed in which geosynthetic material was used to replace the substrate hard-surface slopes. In first technique, is planted directly (GVS), where GVS provides water room for roots. second Hygrophila ringens GVS. exhibits rapid growth initially then dies, creating layer...
We demonstrate a working prototype of an optical breast imaging system involving parallel-plate architecture and dual-direction scanning scheme designed in combination with mammography machine; this was validated pilot study to its application healthy malignant breasts clinical environment. The components modules the self-developed are demonstrated explained, including measuring architecture, mechanism, calibration, reconstruction algorithm is presented. Additionally, evaluation feature...
Abstract Red osier dogwood (ROD) is an abundant native shrub plant in Canada and rich phenolic compounds with antimicrobial properties. The objective of this study was to evaluate the effects ROD extract supplementation on gas production (GP), DM disappearance (DMD) fermentation characteristics batch cultures varying media pH. a completely randomized design 4 inclusion levels (0, 1, 3 5% substrate) × 2 pH (5.8 6.5) factorial arrangement. Substrate high-grain diet (HG) containing 10% barley...