A5061854436- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Bee Products Chemical Analysis
- Skin Protection and Aging
- Toxin Mechanisms and Immunotoxins
- Contact Dermatitis and Allergies
- Nanofabrication and Lithography Techniques
- Microfluidic and Capillary Electrophoresis Applications
- Wireless Body Area Networks
- Protein Interaction Studies and Fluorescence Analysis
- Dermatologic Treatments and Research
- 3D Printing in Biomedical Research
- Salivary Gland Disorders and Functions
- Molecular Communication and Nanonetworks
- Tea Polyphenols and Effects
- Lipid Membrane Structure and Behavior
- Biochemical Analysis and Sensing Techniques
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Phytochemicals and Antioxidant Activities
- Advanced Thermoelectric Materials and Devices
- Hair Growth and Disorders
- Pediatric Pain Management Techniques
Ulsan National Institute of Science and Technology
2023
Yonsei University
2014-2021
Abstract Dissolving microneedles (DMN) supplemented with therapeutic molecules have been developed to enhance transdermal delivery efficiency of topically applied drugs in a minimally invasive manner. However, the dose DMN system is limited owing low solubility drug. In fact, although triamcinolone acetonide (TA) one most widely prescribed for relieving atopic dermatitis (AD), its poor dissolving nature makes it difficult design and fabricate containing dosage TA. this study, TA suspension...
Polymeric microstructures encapsulating biopharmaceutics must be fabricated in a controlled environment to preserve the biological activity. There is increasing demand for simple methods designed activity by utilizing natural properties of polymers. Here, paper shows that centrifugal lithography (CL) can used fabrication such single centrifugation, engineering self-shaping hyaluronic acid (HA). In this method, HA drops are self-shaped into hourglass-microstructures produce two dissolving...
Abstract Objectives Dissolving microneedle patches have been extensively studied in the field of cosmetics comparison with topical focusing on delivery active ingredients. Nevertheless, skin improvement effect hyaluronic acid, which is mainly used as a backbone material for dissolving microneedle, was not analyzed. In this study, adenosine encapsulated high and low molecular weight acid patch (Ad‐HMN Ad‐LMN) were evaluated respect to wrinkling, dermal density, elasticity, safety clinical...
Lidocaine is a local anesthetic agent used in the form of injection and topical cream. However, these formulation types have limitations being either painful or slow-acting, thereby hindering effective complete clinical performance lidocaine. Dissolving microneedles (DMNs) are to overcome owing their fast onset time minimally invasive administration methods. Using hyaluronic acid lidocaine produce drug solution, HCl encapsulated DMN (Li-DMN) was fabricated by centrifugal lithography. The...
Abstract Chronic inflammatory skin diseases (CISDs) negatively impact a large number of patients. Injection triamcinolone acetonide (TA), an anti‐inflammatory steroid drug, directly into the dermis diseased using needle‐syringe systems is long‐established procedure for treating recalcitrant lichenified lesions CISDs, referred to as TA intralesional injection (TAILI). However, TAILI causes severe pain, causing patients be stressed and reluctant undergo treatment. Furthermore, practitioner...
Abstract Dissolving microneedle (DMN) is an attractive alternative to parenteral and enteral drug administration owing its painless self‐administration safety due non‐generation of medical waste. For reproducible efficient DMN administration, various application methods, such as weights, springs, electromagnetic devices, have been studied. However, these applicators complex structures that are complicated use high production costs. In this study, a latch applicator consists only simple...
Background Lidocaine has been widely used as a short-acting local anesthetic agent to reduce the pain caused by needle insertion. Dissolving microneedles (DMNs), which are minimally invasive, can effectively deliver drugs overcoming oral mucosal barrier and relieving patient discomfort.Methods solution prepared mixing lidocaine-HCl hyaluronic acid was fabricate lidocaine HCl-encapsulated DMNs (oral Li-DMNs) via centrifugal lithography. The dissolution, penetration ability, transmucosal drug...
The dissolving microneedle (DMN) patch is a transdermal delivery system, containing arrays of micro-sized polymeric needles capable encapsulating therapeutic drugs within their matrix and releasing them into the skin. However, elastic properties skin prevent DMNs from complete insertion accurate encapsulated compounds Moreover, adhesive materials used in patches may cause irritation, inflammation, redness. Therefore, we developed patchless, micro-pillar integrated DMN (P-DMN) that simple to...
Blood is the gold standard sample medium that can provide a wide variety of useful biological information for diagnosis various diseases. For portable point-of-care diagnosis, blood extraction systems have attracted attention as easier, safer, and more rapid methods collecting small volumes. In this paper, we introduce novel self-powered one-touch system created by assembling smart polymer-capped hollow microneedle in pre-vacuum polydimethylsiloxane actuator. The optimized was precisely...
Abstract Objective Although dissolving microneedle patches have been widely studied in the cosmetics field, no comparisons drawn with topical applications available for routine use. In this study, two wrinkle‐improving products, adenosine‐loaded and an adenosine cream, were evaluated efficacy, respect to skin wrinkling, dermal density, elasticity, hydration, safety a clinical test on crow's feet area. Methods Clinical efficacy tests performed 10 weeks 22 female subjects wrinkles around their...
Abstract Liraglutide, a human glucagon‐like peptide‐1 (GLP‐1) analog, is promising for safely treating type 2 diabetes mellitus (T2DM), compared to insulin, by significantly reducing the risk of glucose‐dependent hypoglycemia. Concerns related injection prevent T2DM patients from taking liraglutide regularly, even though once‐a‐day subcutaneous (SC) injections. Dissolving microneedles (DMNs) are substitutes SC and improving patient convenience. However, there two fundamental limitations: low...
Dissolving microneedle (DMN), a transdermal drug delivery system in which drugs are encapsulated biodegradable polymeric microstructure, is designed to dissolve after skin penetration and release the into body. However, because of limited loading capacity within microsized structures, only small dosage can be delivered, often insufficient for patients. We propose novel DMN application that combines topical simultaneously improve permeation efficiency. Drugs pretreated formulation patch...
Abstract Dissolving microneedles (DMNs) are microscopic needles capable of delivering encapsulated compounds and releasing them into the skin in a minimally invasive manner. Most studies indicate that encapsulating therapeutics DMNs is an efficacious approach; however, importance evaluating activity compounds, during fabrication process, has not been examined detail. Conducting analysis thermal, chemical, physical stress factors, including temperature, pH, interaction polymer mixture...
Summary Background Dissolving microneedles (DMNs), microscale needles with a biodegradable polymer matrix, have been widely investigated for transdermal drug delivery. However, the restricted loading space of DMNs limited delivery desired quantity active compounds. In this study, we developed novel combinatorial therapies involving sequential application adenosine‐loaded DMN (Ad‐DMN) patches and topical cream (Ad‐cream). The created skin channels, which delivered encapsulated drugs from both...
Summary Background Dissolving microneedles (DMNs) have been used for skin restoration and wrinkle improvement. Although lipophilic compounds, example, natural oils or ceramides, enrich the barrier, their delivery via DMNs is challenging because of DMN fabrication difficulties. Objectives In present study, we combined a topical formulation patch to perform two‐phase comprising hydrophilic compound‐loaded improve barrier status efficacy drug delivery. Methods Horse oil‐spread adenosine‐loaded...
Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely safely, their limited penetration through the stratum corneum is a major obstacle to maximizing cosmetic efficacy of HO. Therefore, we aimed encapsulate HO in dissolving microneedle (DMN) for efficient transdermal delivery.To overcome these limitations permeation, HO-loaded DMN (HO-DMN) patches were developed evaluated safety using vitro clinical studies.Despite...
Obesity is a chronic metabolic disease that prevalent worldwide, causing complications affect the quality of life and longevity humans. Currently, low bioavailability upon subcutaneous injection an appetite suppressant, liraglutide, health problems in locally injected region remain to be overcome. In this study, we developed novel hyaluronic acid-based liraglutide-encapsulated triple-layer microneedle (TLM) as painless patient-friendly long-term drug delivery system. contrast previous...
Teriparatide acetate (TA), which directly promotes bone formation, is subcutaneously injected to treat osteoporosis. In this study, TA with a once-weekly administration regimen was loaded on dissolving microneedles (DMNs) effectively deliver it the systemic circulation via transdermal route. activity reduction during drying process of various polymer solutions formulated hyaluronic acid and trehalose monitored homogeneities were assessed. TA-DMN patches fabricated using centrifugal...
Dissolving microneedles (DMNs) have been used as an alternative drug delivery system to deliver therapeutics across the skin barrier in a painless manner. In this study, we propose novel heat-melting method for fabrication of hydrophobic poly(lactic-co-glycolic acid) (PLGA) DMNs, without use potentially harmful organic solvents. The drug-loaded PLGA mixture, which consisted middle layer DMN, was optimized and successfully implanted into ex vivo porcine skin. Implanted HMP-DMNs separated from...
Centrifugal lithography (CL) enables fabrication of microstructures via self-shaping viscous polymer drops during a centrifugation. Hyungil Jung and co-workers fabricate dissolving microneedles (DMNs) composed matrix biopharmaceutics by CL under controlled environments to preserve their activity in article number 1700326. DMNs are penetrated implanted into skin delivered ingredients through the induce biopharmaceutical effects with minimal damage.