A5100328567- Photoreceptor and optogenetics research
- Advancements in Transdermal Drug Delivery
- 2D Materials and Applications
- Advanced Memory and Neural Computing
- Matrix Theory and Algorithms
- Photoacoustic and Ultrasonic Imaging
- Adaptive Control of Nonlinear Systems
- Advanced Optimization Algorithms Research
- Advanced Fluorescence Microscopy Techniques
- Ferroelectric and Negative Capacitance Devices
- Semiconductor materials and devices
- Optimization and Variational Analysis
- Optical Imaging and Spectroscopy Techniques
- Dermatology and Skin Diseases
- CNS Lymphoma Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Gestational Trophoblastic Disease Studies
- Bee Products Chemical Analysis
- Polymer Surface Interaction Studies
- Optical Coherence Tomography Applications
- Salivary Gland Disorders and Functions
- Glioma Diagnosis and Treatment
- Skin Protection and Aging
- Iterative Learning Control Systems
- Transition Metal Oxide Nanomaterials
Seoul National University
2025
University of Illinois Urbana-Champaign
2024-2025
Hanyang University
2024
Yonsei University
2022-2023
Korea Institute of Science and Technology
2017-2022
Korea University
2020-2021
Korea University of Science and Technology
2017-2020
Catholic University of Daegu
2013
Pusan National University
2011-2012
A three-terminal top-gated flash device based on two-dimensional materials with a high coupling ratio exhibits highly linear synaptic weight updates.
Achieving a high-quality metal contact on two-dimensional (2D) semiconductors still remains major challenge due to the strong Fermi level pinning and absence of an effective doping method. Here, we demonstrate high performance "all-PtSe2" field-effect transistors (FETs) completely free from those issues, enabled by vertical integration metallic thick PtSe2 source/drain onto semiconducting ultrathin channel. Owing its inherent thickness-dependent semiconductor-to-metal phase transition,...
Apoptosis plays a crucial role in neuronal injury, with substantial evidence implicating Fas-mediated cell death as key factor ischemic strokes. To address this, inhibition of Fas-signaling has emerged promising strategy preventing and alleviating brain ischemia. However, the challenge overcoming blood–brain barrier (BBB) hampers effective delivery therapeutic drugs to central nervous system (CNS). In this study, we employed 30 amino acid-long leptin peptide facilitate BBB penetration. By...
Teriparatide acetate (TA), which directly promotes bone formation, is subcutaneously injected to treat osteoporosis. In this study, TA with a once-weekly administration regimen was loaded on dissolving microneedles (DMNs) effectively deliver it the systemic circulation via transdermal route. activity reduction during drying process of various polymer solutions formulated hyaluronic acid and trehalose monitored homogeneities were assessed. TA-DMN patches fabricated using centrifugal...
We report a fiber optics-based intravital fluorescence imaging platform that includes epi-fluorescence microscopy and laser patterned-light stimulation system.The can perform real-time with lateral resolution of ~4.9 μm while directly inserted into the intact mouse brain, optically stimulate vasoconstriction during imaging, avoid vessel damage in penetration path probe.Using 473-nm stimulation, we successfully modulated single targeted 37-μm-diameter blood located more than 4.7 mm below...
The performance of robots in high-level tasks depends on the quality their lower-level controller, which requires fine-tuning. However, intrinsically nonlinear dynamics and controllers make tuning a challenging task when it is done by hand. In this paper, we present DiffTune, novel, gradient-based automatic framework. We formulate controller as parameter optimization problem. Our method unrolls dynamical system computational graph updates parameters through optimization. gradient obtained...
Nongestational choriocarcinoma differentiation is extremely rare in breast neoplasms. It characterized by tumor cells similar to chorionic trophoblastic cells, which react with human placental lactogen and gonadotropin (hCG). A 56-year-old woman presented a palpable right mass without past history of tumors. An F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scan revealed one focus low accumulation FDG the (maximum standardized uptake value, 1.98). The...
We present a new fiber-bundle-based endomicroscopy system to measure the fast cerebral blood flow (CBF) velocity in vessels located between surface and deep brain of living animals. The CBF is obtained by measuring displacement partially overlapped red cell images directly, using double-pulse 532-nm laser illumination. proposed method could with diameters ranging from 4 μm 42 velocities up 3.2 μm/ms for different vessel at depth 2.1 mm mouse.
In this study, we examined the effect of C. japonicum flower extract (CFE) on melanogenesis and its mechanism in vitro ex vivo.The CFE was investigated with lightly (HEMn-LP) moderately (HEMn-MP) pigmented normal human melanocytes, reconstituted three-dimensional skin (3D skin) model vivo hair follicles. The melanogenesis-inducing evaluated using melanin content intracellular tyrosinase activity assay. amount type eumelanin pheomelanin were analysed by HPLC method. involved hyperpigmentation...
A synaptic device that contains weight information between two neurons is one of the essential components in a neuromorphic system, which needs highly linear and symmetric characteristics update. In this study, charge trap flash (CTF) memory with multilayered high-κ barrier oxide structure on MoS2 channel proposed. The fabricated was oxide-engineered layers to achieve improved functions. comparison study devices different materials (Al2O3 SiO2) suggests improves operations by demonstrating...
Topical liquid formulations, dissolving microneedles (DMNs), and microscale needles composed of biodegradable materials have been widely used for the transdermal delivery active compounds skincare. However, compound by topical formulation application is inhibited skin barriers, skincare efficacy DMNs restricted low encapsulation capacity incomplete insertion. In this study, serum via a dissolvable micro-channeling system (DMCS) was to enhance through micro-channels embedded with DMNs....
We present all-optical imaging system for studying cerebral blood flow regulation. To investigate changes in the brain, it is necessary to visualize vascular microstructure between neurons, astrocytes, and cells monitor vessel diameter velocity. Optogenetics an excellent technology that can be applied regulation studies require superior spatial temporal resolution individual control of cellular activity. The developed optical a new integrated apply all techniques mentioned above research....
This study investigates the triple-level cell (TLC) memory retention of a MoS2-channel based charge trap flash (CTF) device. A top-gated CTF device with high-κ gate dielectric is found to have high coupling ratio, which enhances tunneling efficiency for programming. The fabricated devices show long performance each state, demonstrating feasibility robust TLC on CVD grown 2D material.
Optogenetics integrated with a variety of genetically encoded methods have been considered very powerful technique for identifying neurovascular coupling mechanism. Recently, optogenetics has applied to non-neuronal cells as well neurons, study the functions various organs and tissues such cardiovascular bladder. However, cerebrovascular network complicated environment in which features coexist. In order successfully apply mechanism, it is necessary develop not only optical stimulation...
Latch Applicator In article number 2210805, Hyungil Jung and co-workers develop a novel applicator that enables efficient skin insertion of dissolving microneedle patches with optimized force velocity. It is cost-competitive simple components easy to use the thumb-force operation. Using model antigen, they show system can produce significantly higher antibodies than intramuscular injection.