A5007730800- Nail Diseases and Treatments
- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Hair Growth and Disorders
- Cutaneous Melanoma Detection and Management
- Plant Pathogens and Fungal Diseases
- Infectious Diseases and Mycology
- Allergic Rhinitis and Sensitization
- Psoriasis: Treatment and Pathogenesis
- Tumors and Oncological Cases
- Cancer and Skin Lesions
- Asthma and respiratory diseases
- Gene expression and cancer classification
- Genetic and rare skin diseases.
- Vascular Malformations and Hemangiomas
- Nonmelanoma Skin Cancer Studies
- Autoimmune Bullous Skin Diseases
- melanin and skin pigmentation
- Advancements in Transdermal Drug Delivery
- Dermatologic Treatments and Research
- Contact Dermatitis and Allergies
- Fungal Infections and Studies
- Hidradenitis Suppurativa and Treatments
- Single-cell and spatial transcriptomics
- Mesenchymal stem cell research
Seoul National University
2016-2023
Seoul National University Hospital
2017-2023
Robert Bosch (Germany)
2023
Michigan United
2020
Weatherford College
2020
Seoul National University Bundang Hospital
2015-2017
Seoul Metropolitan Government
2017
Boramae Medical Center
2017
International Centre for Education in Islamic Finance
2013
University of Nottingham Malaysia Campus
2013
Abstract Dissolving microneedles (DMN) supplemented with therapeutic molecules have been developed to enhance transdermal delivery efficiency of topically applied drugs in a minimally invasive manner. However, the dose DMN system is limited owing low solubility drug. In fact, although triamcinolone acetonide (TA) one most widely prescribed for relieving atopic dermatitis (AD), its poor dissolving nature makes it difficult design and fabricate containing dosage TA. this study, TA suspension...
Abstract Chronic inflammatory skin diseases (CISDs) negatively impact a large number of patients. Injection triamcinolone acetonide (TA), an anti‐inflammatory steroid drug, directly into the dermis diseased using needle‐syringe systems is long‐established procedure for treating recalcitrant lichenified lesions CISDs, referred to as TA intralesional injection (TAILI). However, TAILI causes severe pain, causing patients be stressed and reluctant undergo treatment. Furthermore, practitioner...
Overweight is a well-established risk factor for hidradenitis suppurativa (HS). In this cross-sectional study, we compare HS patients with high body mass index (BMI) low BMI to investigate differences in disease characteristics. Patients were recruited from 17 dermatological centres four continents. A total of 246 below 25 compared 205 above 35. suffered more severe (Hurley, physician global assessment, number areas affected and patient-reported severity (PRS), P < 0.001 all). There was no...
Dermal fibroblasts lose stem cell potency after birth, which prevents regenerative healing. However, the underlying intracellular mechanisms are largely unknown. We uncover postnatal maturation of papillary (PFs) driven by extensive Twist2-mediated remodeling chromatin accessibility. A loss ability PFs occurs with decreased H3K27ac levels. Single-cell transcriptomics, assay for transposase-accessible sequencing (ATAC-seq), and immunoprecipitation (ChIP-seq) reveal trajectory associated in...
Background: Riehl's melanosis presents as a diffuse gray-brown to black hyperpigmentation around face. The treatment of this disease is challenging and quite limited despite patients' excessive psychological stresses.Objective: In prospective pilot study, we evaluated the efficacy safety for novel combination therapy based on low-fluence Q-switched 1064 nm Nd:YAG laser, hydroquinone cream oral tranexamic acid recalcitrant melanosis.Methods: Totally eight patients with who had failed...
Subungual melanoma in situ (SMIS) is a malignant neoplasm that requires early diagnosis and complete surgical excision; however, little known about the usefulness of detailed dermoscopic features longitudinal melanonychia (LM) to predict SMIS.To investigate characteristic findings SMIS establish predictive scoring model for patients with adult-onset LM affecting single digit.A cohort study 19 biopsy-proven 26 benign diagnosed tertiary referral hospital Seoul, South Korea, from September 1,...
Abstract The main factors involved in the pathogenesis of atopic dermatitis (AD) are skin barrier abnormality, allergy/immunology, and pruritus. Considering how oxidative stress influences these factors, antioxidant agents may be effective candidates treatment AD. To evaluate effect Caffeoyl–Pro–His amide (CA-PH), an agent, on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like phenotypes BALB/c mice. Topical sensitization challenge by DNCB were performed dorsal mice to induce cutaneous lesions,...
ArrayXPath (http://www.snubi.org/software/ArrayXPath/) is a web-based service for mapping and visualizing microarray gene-expression data with integrated biological pathway resources using Scalable Vector Graphics (SVG). Deciphering the crosstalk among pathways integrating biomedical ontologies knowledge bases may help interpretation of data. empowered by gene-pathway, disease-pathway, drug-pathway pathway-pathway correlations Gene Ontology, Medical Subject Headings OMIM Morbid Map-based...
Abstract The maintenance of genetic integrity is critical for stem cells to ensure homeostasis and regeneration. Little known about how adult respond irreversible DNA damage, resulting in loss regeneration humans. Here, we establish a permanent model using cycling human hair follicles treated with alkylating agents: busulfan followed by cyclophosphamide. We uncover the underlying mechanisms which follicle (HFSCs) lose their pool. In contrast immediate destructive changes rapidly...
Abstract Digital mucous cysts ( DMC ) are common benign myxoid typically located on the fingers and toes. Recently, dermoscopic patterns of were reported. However, only a small number cases described in published work; therefore, information this topic is scarce work. We investigated histopathologically diagnosed . In total, 23 enrolled study. Polarized dermoscopy revealed vascular 13 (56.5%), with arborizing patterns, dotted vessels, linear vessels polymorphous eight (34.8%), three (13.0%),...
The incidence of melanoma among the Asian population is lower compared to that Western European population. These populations differed in their most common histopathologic subtypes, acral lentiginous being Although dermoscopic features melanomas on skin have been thoroughly investigated population, studies concerning patterns non-acral scarce. aim this study was investigate trunk and extremities To achieve this, we evaluated 22 primary diagnosed at two university hospitals Korea. In...
Female pattern hair loss (FPHL), the most common cause of alopecia in adult women, is classified into two subtypes: early onset and late (or postmenopausal). Little known about clinical features genetic characteristics female (eFPHL).To investigate eFPHL.Patients with eFPHL controls without were prospectively recruited. The demographic collected. Single nucleotide polymorphisms (SNPs) located around selected 30 candidate genes potentially associated evaluated.eFPHL patients (n = 63)...
The regeneration or revascularization of blood vessels after pulsed dye laser (PDL) treatment is one the causes failures cutaneous capillary malformations (CM). Recently, topical administration rapamycin was introduced as a possible adjunctive therapeutic option to minimize postlaser in facial CM.We evaluated effect combined use 1% with PDL compared alone CM trunk extremities and tried identify optimal duration application.Three adjacent areas that had never been treated before were selected...
Abstract Diagnosis of acral lentiginous melanoma in situ (ALMIS) is challenging. However, data regarding ALMIS are limited the literature. The aim this study was to investigate clinical and dermoscopic features on palmoplantar surfaces. Patients with available images were retrospectively reviewed at our institution between January 2013 February 2020. Clinical analysed compared small (< 15 mm) large (≥ ALMIS. Twenty-one patients included study. Mean patient age 58.5 (range 39–76) years;...
Alopecia induced by aging or side effects of medications affects millions people worldwide and impairs the quality life; however, there is a limit to current medications. Here, we identify small transdermally deliverable 5-mer peptide (GLYYF; P5) that activates adiponectin receptor 1 (AdipoR1) promotes hair growth. P5 sufficiently reproduces biological effect protein via AMPK signaling pathway, increasing expression growth factors in dermal papilla cells human follicle. accelerates ex vivo...
Psoriasis is a chronic inflammatory disease. In the treatment of psoriasis, cyclosporine commonly prescribed systemic agents. However, long-term use not recommended because side effects such as nephrotoxicity or hypertension.To ascertain improved safety rotational therapy using and methotrexate, we investigated frequency abnormal results in laboratory test after long term methotrexate.From January 2009 to June 2014, patients who were treated with methotrexate enrolled. The clinical data...