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Abstract Diagnosis of acral lentiginous melanoma in situ (ALMIS) is challenging. However, data regarding ALMIS are limited the literature. The aim this study was to investigate clinical and dermoscopic features on palmoplantar surfaces. Patients with available images were retrospectively reviewed at our institution between January 2013 February 2020. Clinical analysed compared small (< 15 mm) large (≥ ALMIS. Twenty-one patients included study. Mean patient age 58.5 (range 39–76) years;...

Keloids are skin tumours caused by aberrant growth of dermal fibroblasts. Cellular senescence contributes to aging and various pathological conditions, including cancer, atherosclerosis, fibrotic diseases. However, the effects cellular senolytic drugs on keloids remain largely unknown. This study investigated senescent fibroblasts in assessed dasatinib these cells. Tissues acquired from keloid removal surgery were analysed for senescence-associated β-galactosidase-positive cells, p16...

Introduction Lentigo maligna (LM) and lentigo melanoma (LMM) are rare in Asian countries. The histopathological diagnosis of LM is often challenging, misdiagnosis common. Although histopathologic features LM/LMM known, statistical analysis them were scarcely reported. In this study, we aimed to investigate the characteristics Korean patients identify key clues distinguishing from benign lentigo. Methods We performed a retrospective study clinical diagnosed with at our center between 2011...

Green nail syndrome, also known as chloronychia, is a disorder characterized by greenish-black discoloration of the with onycholysis. Pseudomonas aeruginosa causative organism, and it mainly colonizes in an onycholytic relation to green syndrome. Herein, we report rare case syndrome P oryzihabitans infection adverse event art.

Abstract Nevoid basal cell carcinoma syndrome (NBCCS) is mainly characterised by multiple carcinomas (BCCs) caused PTCH1, PTCH2, and SUFU . However, clinical genetic data on Asian NBCCS patients are limited. We aimed to analyse the phenotypes spectrum of Korean with NBCCS. Fifteen at Seoul National University Hospital were included, their analysed. Whole-exome sequencing and/or multiplex ligation-dependent probe amplification using peripheral blood performed identify causes. Genetic analysis...

Abstract Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is a rare Epstein–Barr virus (EBV)-associated disease. The disease course of HVLPD varies from an indolent to progression aggressive lymphoma. We investigated the characteristics in Korean patients. patients at Seoul National University Hospital between 1988 and 2019 were retrospectively analyzed. This study included 26 who all presented with recurrent papulovesicular necrotic eruption on face, neck, extremities. EBV was...

Clinical information that distinguishes invasive nail unit melanoma from in situ before surgery would aid physicians the decision-making process and estimating prognosis. However, limited is available on detailed demographic dermoscopic features of for differential diagnosis.This study aimed to investigate data establish a predictive model differentiating these two forms melanoma.A retrospective observational ninety-seven patients diagnosed with (59 38 cases) four healthcare centres South...

Surgical excision is the treatment of choice for lipomas. However, linear incision methods or minimal extraction techniques often do not provide a sufficient surgical view. Therefore, removing large lipomas difficult. To present Z-incision and half designs lipoma extraction, this retrospective study analyzed surgically excised at our institution between September 2015 December 2018. The area field exposed by versus that was calculated using schematic model. Cure rate, complications, were...

Abstract Background Trachyonychia, a rare inflammatory disease of the nail matrix, has more chronic course in adults compared with that children. However, histopathologic features have not been sufficiently reported literature. Methods We retrospectively reviewed pathologic idiopathic trachyonychia adult cases at our center. Results A total 30 were included. The median age was 55.5 years (range, 27‐77 years). Median duration 84 months 8‐384 months). Histopathologic analysis showed upper...

The purpose of this study was to categorize surgery-related medical terminologies used in South and North Korea compare analyze discrepancies observed the terms.This collected terminology Korean book "Surgery" compared it found glossary Korea. order subtitle described according Instruction Authors.In total, there were 2,168 individual terms, which only 1,004 words (46.3%) identical terms. There 581 similar terms (26.8%), 265 different (12.2%), 318 that are nonexistent (14.7%).Less than half...

Peutz-Jeghers syndrome (PJS; MIM 175200) is an autosomal dominant multiple-organ cancer syndrome. It characterized by brown macules distributed in the perioral skin, oral mucosa, hands and feet, hamartomatous gastrointestinal polyps that can eventually lead to intestinal obstruction, abdominal pain, bleeding, anemia. Patients with PJS are at a higher risk of ovarian, testicular, breast, lung, pancreatic cancers. This predisposition due pathogenic variant serine/threonine kinase 11 (STK11)...

To reduce the drag exerted on blunt forebody in supersonic flight, a spike is mounted front of body. In this paper, flowfields around spike-nosed projectile with fins are simulated numerically to investigate effects diameter, geometry and angle attack. Three dimensional, thin layer form compressible, turbulent Navier-Stokes equations solved using Roe's FDS ADI LU-SGS algorithm. And Baldwin-Lomax turbulence model used consider flow turbulence. The results show that more effective reduction...

Subcorneal pustular dermatosis (SPD), also known as Sneddon–Wilkinson disease, is a rare neutrophilic characterized by recurrent sterile pustules.1 SPD usually occurs in middle-aged or elderly women; however, cases of children with atypical features have been reported the literature.2,3 Herein, we report case 6-year-old boy diagnosed SPD, which caused pityriasis amiantacea (PA).

Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by an accumulation of activated histiocytes within the affected tissues. It heterogeneous that includes classical (nodal) and extra-nodal variants. The cutaneous form without characteristic lymphadenopathy often misdiagnosed as other dermatologic diseases. Misdiagnosis lymphoproliferative infectious diseases such lymphoma tuberculosis have been reported in literature. Herein, we report case facial RDD with...