To compare treatment with preservative-free and preserved sodium hyaluronate 0.1% fluorometholone eyedrops after cataract surgery in patients preexisting dry-eye syndrome.Bucheon St. Mary's Hospital, Catholic University of Korea, Seoul, Korea.Randomized controlled study.Patients syndrome were randomly divided into 2 groups. Group 1 treated 4 times a day the first month twice second month. using same schedule. Ocular Surface Disease Index (OSDI) score, tear-film breakup time (TBUT), Schirmer...

Crowd simulation has been an important research field due to its diverse range of applications that include film production, military simulation, and urban planning. A challenging problem is provide simple yet effective control over captured simulated crowds synthesize intended group motions. We present a new method blends existing crowd data generate animation. The animation can arbitrary number agents, extends for duration, yields natural-looking mixture the input data. main benefit this...

Crowd simulation has been an important research field due to its diverse range of applications that include film production, military simulation, and urban planning. A challenging problem is provide simple yet effective control over captured simulated crowds synthesize intended group motions. We present a new method blends existing crowd data generate animation. The animation can arbitrary number agents, extends for duration, yields natural-looking mixture the input data. main benefit this...

Dermal fibroblasts lose stem cell potency after birth, which prevents regenerative healing. However, the underlying intracellular mechanisms are largely unknown. We uncover postnatal maturation of papillary (PFs) driven by extensive Twist2-mediated remodeling chromatin accessibility. A loss ability PFs occurs with decreased H3K27ac levels. Single-cell transcriptomics, assay for transposase-accessible sequencing (ATAC-seq), and immunoprecipitation (ChIP-seq) reveal trajectory associated in...

Inflammatory bowel disease is a chronic condition characterized by inflammation of the gastrointestinal tract, resulting from an abnormal immune response to normal stimuli, such as food and intestinal flora. Since etiology this remains largely unknown, murine models induced consumption dextran-sodium sulfate serve pivotal tool for studying colon inflammation. In study, we employed both acute colitis mouse varying durations investigate pathological immunologic characteristics throughout...

Abstract The maintenance of genetic integrity is critical for stem cells to ensure homeostasis and regeneration. Little known about how adult respond irreversible DNA damage, resulting in loss regeneration humans. Here, we establish a permanent model using cycling human hair follicles treated with alkylating agents: busulfan followed by cyclophosphamide. We uncover the underlying mechanisms which follicle (HFSCs) lose their pool. In contrast immediate destructive changes rapidly...

Amphiregulin (AREG), a ligand of the epidermal growth factor receptor, is not only essential for proper mammary ductal development, but also associated with breast cancer proliferation and growth. In absence AREG, stunted fails to expand. Furthermore, suppression AREG expression in estrogen receptor-positive tumor cells inhibits in-vitro in-vivo We crossed AREG-null (AREG−/−) mice murine luminal B model, MMTV-PyMT (PyMT), generate spontaneous tumors that lack (AREG−/− PyMT). evaluated...

Alopecia arises due to inadequate hair follicle (HF) stem cell activation or proliferation, resulting in prolongation of the telogen phase cycle. Increasing therapeutic and cosmetic demand for alleviating alopecia has driven research toward discovery synthesis novel compounds that can promote growth by inducing HF proliferation initiating anagen phase. Although several methods evaluating growth-promoting effects candidate are being used, most these difficult use large scale simultaneous...

Sarcopenia is an important health problem, the risk factors of which a few studies have reported on. The purpose this study was to evaluate correlation between sarcopenia and ratio total energy intake basal metabolic rate (BMR) as well physical activity, determine whether relationship different younger older age groups using data from 2008-2011 Korea National Health Nutrition Examination Survey.We analyzed 16,313 subjects than 19 years who had dual X-ray absorptiometry data. defined...

Crowd simulation has been an important research field due to its diverse range of applications that include film production, military simulation, and urban planning. A challenging problem is provide simple yet effective control over captured simulated crowds synthesize intended group motions. We present a new method blends existing crowd data generate animation. The animation can arbitrary number agents, extends for duration, yields natural-looking mixture the input data. main benefit this...

Abstract Induction of new hair follicles (HFs) may be an ultimate treatment goal for alopecia; however, functional cells with HF inductivity must expanded in bulk clinical use. In vitro culture conditions are completely different from the vivo microenvironment. Although fetal and postnatal dermal (DCs) have potential to induce HFs, they rapidly lose this during culture, accompanied by a drastic change gene expression. This suggests that epigenetic regulation involved. Of various histone...

The purpose of this study is to fabricate a 3D printed phantom for computed tomography (CT) imaging and optimize the smoothing factor fast non-local means (FNLM) denoising algorithm. For purpose, printer with fused filament fabrication technology was used produce brain CT diameter 16 cm that mimics cerebrospinal fluid, gray matter, white bone. Then, we added Gaussian noise 0.005 express low-dose conditions from images acquired using phantom. optimization performed by applying FNLM algorithm...

Purpose The purpose of this study was to investigate the significance non-mass enhancement (NME) findings on preoperative breast magnetic resonance imaging (MRI) when invasive cancer patients with single lesions underwent breast-conserving surgery (BCS). Methods We reviewed MRI 252 who BCS from January 2014 September 2016. Based findings, we divided into two groups, those did and not have NME, retrospectively analyzed clinical outcomes groups. Results NME group had 57 patients, no-NME 195...

Purpose: To report two cases of cataract that progressed after COVID-19 mRNA vaccination.Case summary: Two patients visited our clinic with decreased visual acuity in the left eye began vaccine. A 40-year-old man hospital developed 1 week injection second dose mRNA-1273 (Moderna <sup>®</sup> ,Cambridge, UK). woman occurred on day 46 third BNT162b2 (Pfizer , New York, NY, USA). Neither case had any relevant ophthalmic history, and there was no clear optic neuropathy or retinopathy...

Adrenocortical insufficiency is the clinical manifestation of deficient production or action glucocorticoids. It a life-threatening disorder that can result from primary adrenal failure secondary due to impairment hypothalamic-pituitary axis. Primary adrenocortical be caused by autoimmune adrenalitis, infection (especially, tuberculosis), metastatic cancer, lymphoma, hemorrhage, infarction drugs. Among these, hemorrhage may anticoagulant drug heparin therapy, thromboembolic disease,...

본 논문에서는 그래프기반 문장랭킹 방식인 문장 상호 추천과 문장의 주관, 객관 성향을 이용하는 성향 분석을 혼합한 새로운 요약문 추출 방법에 대해서 기술한다. 추천에서는 문장을 단어벡터로 변환한 후에 LSA를 이용하여 문장과 사이의 유사도 점수를 계산하였다. 이렇게 얻어진 유사도와 각 단어의 희귀도(Rarity Score)를 기반으로 연결 강도를 정의하여, 그래프 기반 랭킹 방식을 적용 하였다. 한편, 문장성향 분석에서는 결정하기 위해서 기존의 Golden Standard 단어 분류를 워드넷을 확장하여 데이터베이스를 구축하였다. 이를 통해 단어들의 판단하고 평균 전체 성향에 반영하여, 주관적 띄는 문장들을 선택하였다. 최종적으로 추천 결과와 분석 결과를 혼합하여 주어진 문서로부터 요약문을 추출하였다. 기능의 객관적인 성능 평가를 위하여 추출된 토대로 한 분류게임을 실시하였고, 그 MS-Word에 포함된 문서 요약 기능과 비교함으로써, 제안한 모델의 효과성을 확인하였다. In...