Oxidative stress induced by chronic hyperglycemia in type 2 diabetes plays a crucial role progressive loss of β-cell mass through apoptosis.Glucagon like peptide-1 (GLP-1) has effects on preservation and its insulin secretory function.GLP-1 possibly increases islet cell stimulated proliferation from differentiation to progenitor cells.Also, it probably an antiapoptotic effect β-cell, but detailed mechanisms are not proven.Therefore, we examined the protective mechanism GLP-1 after induction...

The potential relationship between vitamin D (VitD) status and metabolic control in patients with type 2 diabetes mellitus (T2DM) warrants further study.We aimed to evaluate the serum 25-hydroxyvitamin [25(OH)D] level various parameters T2DM.We analyzed retrospectively data from 276 Korean T2DM whose 25(OH)D was measured our hospital.Nondiabetic healthy subjects who visited hospital for health screening were selected as group (Non-DM, n=160).Compared subjects, had a lower (15.4±0.5 vs....

Receptors for glucose-dependent insulinotropic polypeptide (GIP) and glucagon‑like peptide 1 (GLP‑1) are present in vascular endothelial cells. Previous studies investigating euglycemic status have demonstrated that GIP is directly involved the physiology of blood vessels by controlling flow rate portal veins GLP‑1 has a protective effect on acting However, to best our knowledge, effects cells patients with hyperglycemia remain unknown. Therefore, study investigated whether incretin hormones...

Most type 2 diabetes mellitus patients are obese and have obesity related vascular complications. Exenatide treatment is well known for both decreasing glycated hemoglobin levels reduction in body weight. So, this study aimed to determine the effects of exenatide on composition, levels, stiffness patients.For 1 month, 32 were administered 5 μg twice daily. The dosage was then increased 10 μg. Patients' height, weight, lipid profile, pulse wave velocity (PWV), mass index, fat mass, muscle...

Recent studies have revealed that C-peptide induces smooth muscle cell proliferation and causes human atherosclerotic lesions in diabetic patients. The present study was designed to examine whether the basal levels correlate with cardiovascular risk type 2 diabetes mellitus (T2DM) patients.Data obtained from 467 patients T2DM two institutions who were followed for four years. medical findings of all reviewed, creatinine >1.4 mg/dL, any inflammation or infection, hepatitis, 1 DM excluded....

This study aimed to investigate whether stimulated C-peptide is associated with microvascular complications in type 2 diabetes mellitus (DM).A cross-sectional was conducted 192 diabetic patients. Plasma basal and were measured before 6 minutes after intravenous injection of 1 mg glucagon. The relationship between statistically analyzed.In patients retinopathy, 1.9±1.2 ng/mL, 2.7±1.6 ng/mL; values significantly lower compared without retinopathy (P=0.031 P=0.002, respectively). In...

Inflammatory factors and β-cell dysfunction due to high-fat diets aggravate chronic diseases their complications. However, omega-3 dietary fats have anti-inflammatory effects, the involvement of autophagy in etiology diabetes has been reported. Therefore, we examined protective effects on using fat-1 transgenic mice with self-synthesis capability.Streptozotocin (STZ) administration induced mice; blood glucose levels water consumption were subsequently measured. Using hematoxylin eosin (H&E)...

Type 2 diabetes mellitus (T2DM) has a strong genetic component, and its prevalence is notably increased in the family members of T2DM patients. However, there are few studies about history T2DM. We carried out this study to assess influences on clinical characteristics patients.This cross-sectional involving 651 Patient physical examination were performed fasting blood was taken. If any first degree relative diabetic, considered exist.Among total 621 patients, 38.4% had diabetes. Patients...

Sodium-glucose cotransporter 2 inhibitors reduce the risk of cardiovascular death in individuals with type diabetes mellitus (T2DM) and disease, but effect these on early disease remains unknown. This study evaluated dapagliflozin metabolic profiles endothelial cell function obese patients T2DM without established disease.We enrolled 140 a mean age, weight, body mass index (BMI) 47 years, 83 kg, 30.3 kg/m2, respectively. Dapagliflozin (10 mg daily for 6 months) was administered to disease....

Background: It is well known that high serum ferritin, a marker of iron storage, predicts incident type 2 diabetes.Limited information available on the association between transferrin, another metabolism, and diabetes.Thus, we investigated transferrin diabetes.Methods: Total 31,717 participants (mean age, 40.4±7.2years) in health screening program 2005 were assessed via cross-sectional analysis.We included 30,699 subjects who underwent medical check-up 2009 did not have diabetes at baseline...

<h3>Aim</h3> To report the outcome at 5-year follow-up of a defined series patients with primary periocular basal cell carcinoma treated by cryotherapy using nitrous oxide probe. <h3>Methods</h3> A prospective, non-comparative, interventional case series. One hundred carcinomas were double freeze–thaw cycle contact Inclusion criteria clinically well-defined maximum diameter 8 mm. The main measure was histologically proven recurrence rate follow-up. <h3>Results</h3> Kaplan–Meier survival...

Introduction A study was conducted to describe the sedation practices of intensive care units (ICUs) in Singapore terms drug use, depth and incidence delirium both early ( 48 hours) periods ICU admission. Methods prospective multicentre cohort on patients who were expected be sedated ventilated for over 24 hours seven ICUs (surgical ICU, n = 4; medical 3) four major public hospitals Singapore. Patients followed up 28 days or until discharge, with four-hourly monitoring daily assessment by...

We appreciate the comments on our study “Basal C-peptide level as a surrogate marker of subclinical atherosclerosis in type 2 diabetes patients,” which was published Diabetes & Metabolism Journal 2011;35:41-49 [1]. Many studies have reported that high levels HbA1c are strongly associated with increased risks cardiovascular disease and microvascular complications [2]. However, recent while use intensive therapy to target glycated hemoglobin below 6% reduces 5-year nonfatal myocardial...

We report a case of ruptured triple hormone-secreting adrenal mass with hyperaldosteronism, hypercortisolism, and elevated normetanephrine levels, diagnosed as cortical carcinoma (ACC) by histology. A 53-year-old male patient who initially presented abdominal pain was referred to our hospital for angiocoagulation an rupture. Abdominal computed tomography revealed heterogeneous 19×11×15 cm right invasion into the lobe liver, inferior vena cava, retrocaval lymph nodes, aortocaval nodes....

Teratoma is a congenital tumor containing tissues derived from all germ layers. in the region of adrenal gland very uncommon retroperitoneal tumor. Only 7 cases teratoma have been reported worldwide, but Korea, no similar until now. This case report describes an 38-year-old healthy woman who was incidentally diagnosed with left mass on abdominal ultrasonography during medical inspection. Computed tomographic scans revealed 9-cm heterogeneous circumscribed round mass, primarily fat tissue,...

Internal myiasis is a rare disease, which has not been reported in Korea, yet. This case report describes patient with pneumonia associated internal myiasis. She was 84-year old female who admitted to the emergency department, Konyang University Hospital as result of dyspnea and fever drowsy mental state. Approximately twenty fly maggots continuously crawled out from nose at third hospital day intensive care unit. These were almost 7.2mm long identified genus lucilia belonging family...

Adrenocortical insufficiency is the clinical manifestation of deficient production or action glucocorticoids. It a life-threatening disorder that can result from primary adrenal failure secondary due to impairment hypothalamic-pituitary axis. Primary adrenocortical be caused by autoimmune adrenalitis, infection (especially, tuberculosis), metastatic cancer, lymphoma, hemorrhage, infarction drugs. Among these, hemorrhage may anticoagulant drug heparin therapy, thromboembolic disease,...

Multiple endocrine neoplasia type 2B (MEN 2B) is an autosomal dominant disorder characterized by medullary thyroid cancer, pheochromocytoma, neuroma and Marfanoid feature. Medullary cancer occurs in more than 95% patients of MEN increases mortality. So, the early diagnosis multiple very important, because diagnosed treated prognosis excellent. This a case that conjunctival neuroma. A 15-year-old female patient was presented with both masses occurred 6 months ago. The excisional biopsy...

Objectives : Endobronchial anthracofibrotic pigmentation, which presents as dark black or brown pigmentation mucosal changes of multiple bronchi combined with bronchial fibrosis and obstruction, is not a rare finding when performing diagnostic bronchoscopy for Koreans.This study was performed to define the clinical characteristics determine association these Korean life style such other diseases coal workers, pneumoconiosis tuberculosis in patients pigmentation.Methods This retrospective...