To investigate the molecular basis of drug resistance in pancreatic cancer.

Purpose: This study evaluated the therapeutic efficacy of intravitreal methotrexate (MTX) injections in patients diagnosed with intraocular lymphoma via vitrectomy and immunocytochemical staining.Methods: In a retrospective analysis medical records, we reviewed data from four (six eyes) cytologically after undergoing at our hospital between December 2021 2023. Each case was followed for minimum 6 months treatment, comparisons made pre- post-treatment observationsResults: The mean age 63.5 ±...

MicroRNA (miRNA) has a critical effect on tumorigenesis through post‐transcriptional modification and is considered to be potential biomarkers for cancer diagnosis treatment monitoring. We evaluated the expression pattern of three selected miRNAs (miR‐21, miR‐155, let‐7a) evaluate their roles by quantitative reverse transcription‐polymerase chain reaction using formalin‐fixed paraffin‐embedded tissues 63 surgically resected pulmonary neuroendocrine (NE) tumors (19 typical carcinoids (TCs), 6...

Abstract Context.—Mucin 4 (MUC4) is a high-molecular-weight membrane–bound glycoprotein that expressed in the foregut before epithelial differentiation. It found normal adult airway epithelium, non–small cell lung carcinoma (NSCLC) and other human malignancies independent of mucus secretion. Although its tissue distribution has been studied, utility predicting prognosis NSCLC unknown. Objective.—To evaluate relationship between MUC4 overexpression long-term survival patients with NSCLC....

Abstract Context.—Mucin 4 (MUC4) is a high-molecular-weight membrane–bound glycoprotein that expressed in the foregut before epithelial differentiation. It found normal adult airway epithelium, non–small cell lung carcinoma (NSCLC) and other human malignancies independent of mucus secretion. Although its tissue distribution has been studied, utility predicting prognosis NSCLC unknown. Objective.—To evaluate relationship between MUC4 overexpression long-term survival patients with NSCLC....

The differentiation of malignant mesotheliomas and benign mesothelial proliferations is crucial in determining patient care prognosis. But, this distinction can be extremely difficult, particularly small biopsies. Recently, insulin‐like growth factor II mRNA ‐binding protein 3 ( IMP3 ) glucose transporter 1 GLUT ‐1) have been reported as specific sensitive markers the from proliferations. purpose study to evaluate utility , ‐1, epithelial membrane antigen EMA immunohistochemistry for...

Adefovir dipivoxil (ADV) is a nucleotide used as long-term therapy of chronic hepatitis B. Many published reports have shown that high-dose with adefovir can be associated proximal renal tubular dysfunction resulting in significant hypophosphatemia, insufficiency and osteomalacia. We encountered two patients who developed evidence hypophosphatemic osteomalacia while on low-dose for report its clinical features potential resolution cessation the drug supplementation phosphate. also reviewed...

Perineuriomas are composed of differentiated perineurial cells. have been recently recognized by the immunoreactivity for epithelial membrane antigen (EMA). Microscopically, perineuriomas show proliferation spindle cells with wavy nuclei and delicate elongated bipolar cytoplasmic processes. The tumor usually negative S-100 protein. Ultrastructurally, reveal slender, nontapered processes containing pinocytic vesicles discontinuous basal lamina. Interestingly, hybrid tumors benign peripheral...

Ha S Y, Lee C H, Chang H K, S, Kwon K E Roh M & Seo B (2012) Histopathology 60, 731–739 Differential expression of forkhead box M1 and its downstream cyclin‐dependent kinase inhibitors p27 kip1 p21 waf1/cip1 in the diagnosis pulmonary neuroendocrine tumours Aims: Pulmonary (NE) represent a spectrum phenotypically distinct entities with different biological behaviours. Difficulties classifying these are frequently encountered clinical practice. Forkhead (FoxM1) is essential for...

The purpose of this study was to investigate the prognostic significance expression EGFR and C-erbB-2 gene products by immunohistochemical analysis for curatively resected gastric adenocarcinoma.Between January 1996 December 2001, 739 patients with cancer underwent staining proteins, we retrospectively analyzed their correlation clinical outcome.The over expressions were 25.4% 26.2%, respectively. associated more poorly differentiated tumor (p=0.000) neuronal invasion (p=0.03). Over less...

Acute kidney injury frequently accompanies sepsis. Endotoxin is known to reduce tissue levels of cAMP and low have been associated with renal injury. We, therefore, hypothesized that endotoxin induced by activating phosphodiesterase 3 (PDE3) which metabolizes amrinone an inhibitor PDE3 would prevent the injury.Animals were divided into three groups (n = 7/group): 1) Control (0.9% NaCl infusion without LPS); 2) LPS 3) Amrinone+LPS (Amrinone LPS). Either lipopolysaccharide (LPS) or vehicle was...

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (extranodal MZL) is a distinct subgroup non-Hodgkin's lymphoma. Pulmonary extranodal MZL rare entity and accounts for less than 0.5% primary pulmonary malignancies. Only few cases simultaneous occurrence lung cancer have been reported. A 60-year-old woman was referred to our hospital with nodule. She diagnosed adenocarcinoma by percutaneous needle biopsy. The protrusions into the left main bronchus were found...

The development of diagnostic techniques and an awareness health examinations can bring about early diagnosis lung cancer. However, appropriate postoperative management adjuvant chemotherapy remain under debate in therapeutic strategy. present study was conducted to assess the clinicopathologic factors that influence recurrence prognosis after complete resection cancer.The analyzed 62 patients with cancer who underwent diagnosed adenocarcinoma between 1994 2007. In addition conventional...

Endometrial cancer is the third most common gynecologic in Korea and occurs mainly menopausal women. Although it can develop young premenopausal women as well, an attack adolescent girl very rare. A 13-year-old visited gynecology department with complaint of abnormal uterine bleeding. An endometrial biopsy revealed FIGO (International Federation Gynecology Obstetrics) grade II adenocarcinoma. In treatment cancer, conservative management should be considered if patient nulliparous or wants...

We examined the ultrastructural features of lung parenchyma and expression apoptosis respiratory cells by TUNEL technique.Male Sprague-Dawley rats (n=30) were intra-tracheally injected with cadmium (2.5 mg/kg) into both lungs.The light electron microscopic tissues on Days 1, 3, 7 10 after injection cadmium.Specimen preparations for stains performed.Ultrastructurally, 1 alveolar spaces filled edematous fluid, desquamated type I epithelial cells.On 10, interstitium patchy infiltrated young...

Tuberculous pleural effusion (TPE) is one of the most common forms extrapulmonary tuberculosis. Because studies TPE focused on space, little information regarding lung parenchyma available. We therefore aimed to investigate immune responses in patients without pulmonary tuberculosis.Patients with any evidence tuberculosis, either from radiologic or bacteriologic evaluation, were excluded. Bronchoalveolar lavage fluid (BALF) was collected 10 newly diagnosed, untreated, HIV-negative and...

Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation sarcoidal granuloma in neck nodes without typical manifestations sarcoidosis is difficult to diagnose. We describe the case 37-year-old woman with an increasing mass on right side neck. excisional biopsy from showed noncaseating epithelioid cell lymph nodes. No evidence mycobacterial or fungal infection was noted. Thoracic evaluations did not show enlargement mediastinal parenchymal abnormalities....

Profibrotic properties of pleural mesothelial cells may play an important role in the fibrosis activity idiopathic pulmonary (IPF). The purpose this study was to compare expression cell markers IPF and cryptogenic organizing pneumonia (COP), with assumption that increased implies increase fibrosis.Twenty lung samples were stained by immunohistochemistry for markers: leucine rich repeat neuronal 4 (LRRN4), uroplakin 3B, CC-chemokine ligand 18, laminin-5. Nine COP used as controls. A...

Rectal suction biopsy with acetylcholinesterase (AChE) histochemistry has gained increased acceptance as the means of definitely diagnosing Hirschsprung's disease (HD) well excluding this diagnosis when evaluating children low intestinal obstruction or chronic constipation since report Meier-Ruge et al. in 1972. But AChE histochemical study not been reported yet Korea. During 14-month period from April, 1991 through June, 1992, 37 children, aged 3 days to 17 years had rectal biopsies for...

Background : Mucin (MUC)1 and MUC4 (MUC1, 4) are high molecular weight glycoproteins expressed in normal malignant epithelial cells, these expressions related to the prognosis of some carcinomas.In non-small cell lung carcinoma (NSCLC), relationship between MUC1, 4 their prognostic significance is not well known.We evaluated relationships a series NSCLC: 1) expression levels histologic subtypes, 2) significance.Methods We performed immunohistochemical staining for paraffin-embedded tissues...