A5054376342- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Abdominal Trauma and Injuries
- Trauma and Emergency Care Studies
- Hemostasis and retained surgical items
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Pelvic and Acetabular Injuries
- Respiratory Support and Mechanisms
- Neuroendocrine regulation and behavior
- Platelet Disorders and Treatments
- Surgical Sutures and Adhesives
- Phosphodiesterase function and regulation
- Angiogenesis and VEGF in Cancer
- Neonatal Respiratory Health Research
- Optical Imaging and Spectroscopy Techniques
- Immune Response and Inflammation
- Pulmonary Hypertension Research and Treatments
- Proteoglycans and glycosaminoglycans research
- Nitric Oxide and Endothelin Effects
- Asthma and respiratory diseases
- Cardiac Fibrosis and Remodeling
- Muscle and Compartmental Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Protease and Inhibitor Mechanisms
Massachusetts General Hospital
1998-2023
Harvard University
1996-2023
American Association for the Surgery of Trauma
2014
Arsenal Medical (United States)
2014
Watertown City School District
2014
Pulmonary Associates
2009
BACKGROUND Intracavitary noncompressible hemorrhage remains a significant cause of preventable death on the battlefield. Two dynamically mixed and percutaneously injected liquids were engineered to create an in situ self-expanding polymer foam facilitate hemostasis massive bleeding. We hypothesized that intraperitoneal injection could achieve conformal contact with sites injury improve survival swine lethal hepatoportal injury. METHODS High grade was created closed abdominal cavity,...
Noncompressible abdominal bleeding is a significant cause of preventable death on the battlefield and in civilian trauma environment, with no effective therapies available at point injury. We previously described development percutaneously administered, self-expanding, poly(urea)urethane foam that improved survival lethal Grade V hepatic portal vein injury model swine. In this study, we hypothesized treatment dose dependent.A high-grade hepatoportal was created closed cavity, resulting...
Noncompressible abdominal bleeding is a significant cause of preventable death on the battlefield and in civilian setting, with no effective therapies available at point injury. We previously reported that self-expanding polyurethane foam significantly improved survival lethal hepatoportal injury model massive venous hemorrhage. In this study, we hypothesized treatment could improve iliac artery noncoagulopathic swine.In swine closed abdomen, an transection was created, resulting...
Intracavitary noncompressible hemorrhage remains a significant cause of preventable death on the battlefield and in homeland. We previously demonstrated hemostatic efficacy an situ self-expanding poly(urea)urethane foam severe, closed-cavity, hepatoportal exsanguination model swine. hypothesized that treatment with, subsequent explantation of, would not adversely impact 28-day survival swine.Following closed-cavity splenic transection, animals received either fluid resuscitation alone...
Noncompressible abdominal hemorrhage is a significant cause of battlefield and civilian mortality. We developed self-expanding polyurethane foam intended to provide temporary control enable evacuation definitive surgical capability, for casualties who would otherwise die. hypothesized that treatment be efficacious over wide range out-of-hospital operational conditions.The was tested in an established lethal, closed-cavity hepatoportal injury model four groups as follows. Group 1 involved...
We have previously described the hemostatic efficacy of a self-expanding polyurethane foam in lethal venous and arterial hemorrhage models. A number critical translational questions remain, including prehospital diagnosis hemorrhage, use with diaphragmatic injury, effects on spontaneous respiration, role omentum, presence laparotomy properties.In Experiment 1, diagnostic blood aspiration was attempted through Veress needle before deployment during exsanguination (n = 53). In 2: hepatoportal...
Acute kidney injury frequently accompanies sepsis. Endotoxin is known to reduce tissue levels of cAMP and low have been associated with renal injury. We, therefore, hypothesized that endotoxin induced by activating phosphodiesterase 3 (PDE3) which metabolizes amrinone an inhibitor PDE3 would prevent the injury.Animals were divided into three groups (n = 7/group): 1) Control (0.9% NaCl infusion without LPS); 2) LPS 3) Amrinone+LPS (Amrinone LPS). Either lipopolysaccharide (LPS) or vehicle was...
Smoke inhalation injury is a serious threat to victims of fires and explosions, however accurate diagnosis patients remains problematic. Current evaluation techniques are highly subjective, often involving the integration clinical findings with bronchoscopic assessment. It apparent that new quantitative methods for evaluating airways at risk needed. Optical frequency domain imaging (OFDI) high resolution optical modality enables volumetric microscopy trachea upper in vivo. We anticipate OFDI...
Background Previous studies have indicated heparin which has both anti‐coagulant and anti‐proliferative properties, may be used as a possible therapeutic agent for the treatment of post‐angioplasty restenosis. CD 44 is receptor hyaluronan plays essential roles in many aspects including SMC proliferation, inflammation injury repair. This study investigates effects on injury‐induced femoral artery remodeling expression , to illuminate molecular mechanism by blocks stenosis. Hypothesis Heparin...