A5017607400- Occupational and environmental lung diseases
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Air Quality and Health Impacts
- Sarcoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Acute Kidney Injury Research
- Vascular Tumors and Angiosarcomas
- Cancer Research and Treatments
- Energy and Environment Impacts
- Vascular Malformations and Hemangiomas
- Climate Change and Health Impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiomics and Machine Learning in Medical Imaging
- Intraperitoneal and Appendiceal Malignancies
- Neonatal Respiratory Health Research
- Myasthenia Gravis and Thymoma
- Colorectal Cancer Treatments and Studies
- Histiocytic Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Cystic Fibrosis Research Advances
- Lung Cancer Diagnosis and Treatment
- Optical Coherence Tomography Applications
Yonsei University
2013-2024
University of Ulsan
2016
Keimyung University
2016
Seoul National University
2016
Ulsan College
2016
American Dental Hygienists' Association
2014
Chungnam National University
2011
Wonju Severance Christian Hospital
1994-2008
Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer that develops in the outer layer of tissues surrounding lungs. MPM primarily caused by occupational exposure to asbestos results poor prognosis. Effective therapeutics as well early diagnostics for are still lacking. To identify potential diagnostic biomarkers MPM, we performed bioinformatics analysis public database.Utilizing databases from Cancer Cell Line Encyclopedia (CCLE) Gene Expression Omnibus (GEO), identified...
The objectives of this study were to examine trends in mesothelioma incidence over a decade and identify histories asbestos exposure among cases Korea.In 2001, Korea Occupational Safety Health Agency organized nationwide cardiopulmonary pathology group established malignant surveillance system covering all general hospitals Korea. Mesothelioma reported with information about age, gender, location, occupational history, environment, date diagnosis, diagnostic method, histopathologic subtype,...
Objective: To compare the multidetector CT (MDCT) features of malignant pleural mesothelioma (MPM) and metastatic disease (MPD). Materials Methods:The authors reviewed MDCT images 167 patients, 103 patients with MPM 64 MPD.All cases were pathologically confirmed by sonography-guided needle biopsy pleura, thoracoscopic biopsy, or open thoracotomy.CT evaluated respect to effusion, thickening, invasion other organs, lung abnormality, lymphadenopathy, mediastinal shifting, thoracic volume...
Lung cancer is a major cause of cancer-related death worldwide. It believed that obesity-related malignancies such as breast, endometrial, colorectal, and kidney carcinomas have lower plasma level and/or tissue expression adiponectin receptors. However, the association between receptors lung cancer, non malignancy, still unknown. We evaluated receptor (AdipoR) 1 AdipoR2 in 83 cases non-small cell carcinoma (NSCLC) matched non-neoplastic tissues by immunohistochemistry real-time polymerase...
We present a polarization-sensitive optical coherence tomography (PS-OCT) technique that can quantify the polarization changes (the degrees of circular polarization, DOCP) caused by scattering induced cervical intraepithelial neoplasia (CIN). The axial and lateral resolutions our PS-OCT system are 13 microm 15 microm, respectively. Uterine conization tissue samples from 18 patients were examined, 71 areas imaged for in vitro studies; about 2-4 per sample processed diagnosis. scanned had size...
Primary thymic mucinous adenocarcinoma is an extremely rare aggressive subtype of carcinoma. With a review literatures, only nine cases have been reported up to present. A 36-year-old woman was admitted for further evaluation and treatment mediastinal mass. The patient had no medical history cancer. clinicoradiological examination disclosed tumor elsewhere. After the surgical excision mass, it grossly round semi-solid mass with mucin-filled cystic areas. Microscopically solid areas showed...
The differentiation of malignant mesotheliomas and benign mesothelial proliferations is crucial in determining patient care prognosis. But, this distinction can be extremely difficult, particularly small biopsies. Recently, insulin‐like growth factor II mRNA ‐binding protein 3 ( IMP3 ) glucose transporter 1 GLUT ‐1) have been reported as specific sensitive markers the from proliferations. purpose study to evaluate utility , ‐1, epithelial membrane antigen EMA immunohistochemistry for...
Objective: This study evaluated the CT characteristics of pleural plaques in asbestos-exposed individuals and compared occupational versus environmental exposure groups. Materials Methods:This enrolled 181 subjects with 98 from chrysotile asbestos mines, who had confirmed by a chest CT.The scans were analyzed for morphological characteristics, number distribution combined pulmonary fibrosis.Furthermore, findings between groups.Results: Concerning 279 subjects, single 2.2% unilateral 3.6%,...
Malignant mesothelioma is an aggressive tumor occurring in mesothelial cells of the pleura and peritoneum. This cancer attributable to asbestos 80~90% patients. Asbestos has been widely used Korea since 1970s, therefore, a large number Korean workers, especially who engaged industries textiles, shipbuilding, or construction, have exposed occupationally. several kinds statistics showing mortality morbidity, which include registry data, surveillance data. According annual report Central Cancer...
Mutations of the epidermal growth factor receptor (EGFR) are strongest predictive for response to EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. TKIs approved in Korea a first-line treatment lung cancer patients with mutated EGFR. Rapid accurate mutation testing is essential patient selection establishing targeted therapies TKIs. Thus, standard set guideline recommendations suitable Korean medical community necessary. In this article, we propose that was discussed...
Congenital pulmonary lymphangiectasis (CPL) is a rare, poorly documented disease, characterized by abnormal dilatation of lymphatics without lymphatic proliferation. This disease seen almost exclusively in infancy and early childhood. It can usually be divided into primary (congenital) secondary forms. The form presents neonates, the patients mostly die due to respiratory distress, shortly after birth. authors experienced two cases CPL 13-day-old male neonate one-day-old neonate, showing...
Toll-like receptor 4 (TLR-4) is the major used for recognition of specific gram negative bacteria by host immune system. The role TLR-4 has been revealed in preterm parturition. This study aims to demonstrate immunohistochemical expression with regard histological layers and anatomical regions human fetal membranes.Fetal membranes were obtained from uterine fundus low segment. Immunohistochemical staining hematoxylin eosin stain performed.The chorion expressed significantly higher levels...
Objective To compare the diagnostic performance of contrast-enhanced radial T1-weighted gradient-echo 3-tesla (3T) magnetic resonance imaging (MRI) and computed tomography (CT) for detection visceral pleural surface invasion (VPSI). Visceral by non-small-cell lung cancer (NSCLC) can be classified into two types: PL1 (without VPSI), elastic layer pleura without reaching surface, PL2 (with full pleura. Materials methods Thirty-three patients with pathologically confirmed VPSI NSCLC were...
Cancer cells are distinct in terms of glutamine dependence. Here we investigated the different susceptibility glutamine-independent and glutamine-dependent non-small cell lung cancer (NSCLC) to treatment with tumor necrosis factor receptor-associated protein 1 (TRAP1) inhibitor gamitrinib-triphenylphosphonium (G-TPP).Cell viability proliferation under deprivation G-TPP were determined by MTT colony-formation assays. Protein mRNA expression western blot quantitative polymerase chain reaction....