A5001356432- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- HER2/EGFR in Cancer Research
- Cancer-related gene regulation
- Single-cell and spatial transcriptomics
- Wnt/β-catenin signaling in development and cancer
- Metastasis and carcinoma case studies
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Colorectal and Anal Carcinomas
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2014-2024
Seoul National University Hospital
2015-2023
New Generation University College
2005-2023
Lee University
2023
National University College
2012-2023
Weatherford College
2023
Stanford University
2023
Northwell Health
2022
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2022
Biomarkers on the basis of tumor-infiltrating lymphocytes (TIL) are potentially valuable in predicting effectiveness immune checkpoint inhibitors (ICI). However, clinical application remains challenging because methodologic limitations and laborious process involved spatial analysis TIL distribution whole-slide images (WSI).We have developed an artificial intelligence (AI)-powered WSI analyzer tumor microenvironment that can define three phenotypes (IPs): inflamed, immune-excluded,...
Background The inflamed immune phenotype (IIP), defined by enrichment of tumor-infiltrating lymphocytes (TILs) within intratumoral areas, is a promising tumor-agnostic biomarker response to checkpoint inhibitor (ICI) therapy. However, it challenging define the IIP in an objective and reproducible manner during manual histopathologic examination. Here, we investigate artificial intelligence (AI)-based phenotypes capable predicting ICI clinical outcomes multiple solid tumor types. Methods...
The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR mutation-positive non-small-cell lung cancer (NSCLC) patients necessitates accurate, timely testing. Although mutation testing has been adopted by many laboratories Asia, data are lacking on the proportion NSCLC tested each country, and most commonly used methods.A retrospective survey records from for mutations during 2011 was conducted 11 Asian Pacific countries at 40 sites that routinely performed...
Purpose Programmed death-1 (PD-1)/PD-1 ligand (PD-L1) axis blockades have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). We assessed effect platinum-based chemotherapy on tumor PD-L1 expression and its clinical implications. Materials Methods used immunohistochemistry to retrospectively evaluate percentage cells with membranous staining (tumor proportion score) in paired specimens obtained before after neoadjuvant (NACT) 86 patients NSCLC. analyzed correlation...