A5039722034- Protein Kinase Regulation and GTPase Signaling
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Melanoma and MAPK Pathways
- Cellular transport and secretion
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Radiopharmaceutical Chemistry and Applications
- Developmental Biology and Gene Regulation
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Ubiquitin and proteasome pathways
- Lung Cancer Treatments and Mutations
- HER2/EGFR in Cancer Research
- Microbial metabolism and enzyme function
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Metabolism, Diabetes, and Cancer
- Erythrocyte Function and Pathophysiology
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
The University of Texas MD Anderson Cancer Center
2016-2023
Institut de Biologia Evolutiva
2013-2022
Universitat Pompeu Fabra
2015-2022
Institut Català d'Oncologia
2013
Universitat de Barcelona
2013
Biomedical Research Institute of Lleida
2013
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2013
Institut d'Investigació Biomédica de Bellvitge
2013
This study identifies a molecular basis for malignant secretion and provides rationale to test PI4KIIIβ antagonists as an intervention.
Abstract KRAS phosphorylation has been reported recently to modulate the activity of mutant protein in vitro. In this study, we defined S181 as a specific site required license oncogenic function vivo. The phosphomutant S181A failed induce tumors mice, whereas phosphomimetic S181D exhibited an enhanced tumor formation capacity, compared with wild-type protein. Reduced growth composed cells expressing nonphosphorylatable was correlated increased apoptosis. Conversely, activation AKT and ERK,...
// Lisa Maria Mustachio 1 , Masanori Kawakami 2 Yun Lu Jaime Rodriguez-Canales 3 Barbara Mino Carmen Behrens Ignacio Wistuba Neus Bota-Rabassedas Jun Yu 4 J. Jack Lee Jason Roszik 5,6 Lin Zheng Xi Liu Sarah Freemantle and Ethan Dmitrovsky 1,2,7 Department of Pharmacology Toxicology, Geisel School Medicine at Dartmouth, Hanover, NH, USA Thoracic/Head Neck Medical Oncology, The University Texas MD Anderson Cancer Center, Houston, TX, Translational Molecular Pathology, Biostatistics, 5 Melanoma...
Abstract Collagen lysyl hydroxylases (LH1-3) are Fe 2+ - and 2-oxoglutarate (2-OG)-dependent oxygenases that maintain extracellular matrix homeostasis. High LH2 levels cause stable collagen cross-link accumulations promote fibrosis cancer progression. However, developing LH antagonists will require structural insights. Here, we report a 2 Å crystal structure X-ray scattering on dimer assemblies for the domain of L230 in Acanthamoeba polyphaga mimivirus . Loop residues double-stranded β-helix...
Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the clinical outcome of lung cancer patients have not been fully elucidated. Because Thy-1 (CD90) marks CAFs tumor cell invasion in a murine model KrasG12D-driven adenocarcinoma (KrasLA1), here we postulated human adenocarcinomas containing Thy-1+ worse prognosis. We first examined location within adenocarcinomas....
Therapeutic strategies designed to target TP53-deficient cancer cells remain elusive. Here, we showed that TP53 loss initiated a pharmacologically actionable secretory process drove lung adenocarcinoma (LUAD) progression. Molecular, biochemical, and cell biological studies increased the expression of Golgi reassembly stacking protein 55 kDa (G55), maintains organelle integrity is part GOLGIN45 (G45)-myosin IIA-containing complex activates vesicle biogenesis in Golgi. activated G55-dependent...
Abstract Epithelial-to-mesenchymal transition (EMT) is a transcriptionally governed process by which cancer cells establish front-rear polarity axis that facilitates motility and invasion. Dynamic assembly of focal adhesions other actin-based cytoskeletal structures on the leading edge motile requires precise spatial temporal control protein trafficking. Yet, way in EMT-activating transcriptional programs interface with vesicular trafficking networks effect cell change remains unclear. Here,...
Cancer cells are a major source of enzymes that modify collagen to create stiff, fibrotic tumor stroma. High lysyl hydroxylase 2 (LH2) expression promotes metastasis and is correlated with shorter survival in lung adenocarcinoma (LUAD) other types. LH2 hydroxylates lysine (Lys) residues on fibrillar collagen's amino- carboxy-terminal telopeptides stable cross-links. Here, we show electrostatic interactions between the LH domain active site determine unique telopeptidyl (tLH) activity LH2....
Abstract Purpose: Our understanding of the immunopathology resectable non–small cell lung cancer (NSCLC) is still limited. Here, we explore immune programs that inform tumor immunity and response to neoadjuvant chemotherapy chemoimmunotherapy in localized NSCLC. Experimental Design: Targeted gene sequencing using HTG Precision Immuno-Oncology panel was performed NSCLCs from three cohorts based on treatment: naïve (n = 190), 38), 21). Tumor microenvironment (TIME) phenotypes were location...
A chromosome 1q21.3 region that is frequently amplified in diverse cancer types encodes phosphatidylinositol (PI)-4 kinase IIIβ (PI4KIIIβ), a key regulator of secretory vesicle biogenesis and trafficking. Chromosome 1q21.3-amplified lung adenocarcinoma (1q-LUAD) cells rely on PI4KIIIβ for Golgi-resident PI-4-phosphate (PI4P) synthesis, prosurvival effector protein secretion, cell viability. Here, we show 1q-LUAD subjected to prolonged antagonist treatment acquire tolerance by activating an...
Abstract How several signaling pathways are coordinated to generate complex organs through regulation of tissue growth and patterning is a fundamental question in developmental biology. The larval trachea Drosophila composed differentiated functional cells groups imaginal tracheoblasts that build the adult during metamorphosis. Air sac primordium (ASP) tracheal form dorsal air sacs supply oxygen flight muscles adult. ASP emerges from branch connects wing disc by activation both Bnl-FGF/Btl...
Collagenous stromal accumulations predict a worse clinical outcome in variety of malignancies. Better tools are needed to elucidate the way which collagen influences cancer cells. Here, we report method generate collagenous matrices that deficient key post-translational modifications and evaluate cell behaviors on those matrices. We utilized genetic biochemical approaches inhibit lysine hydroxylation glucosylation produced by MC-3T3-E1 murine osteoblasts (MC cells). Seeded onto MC...
Supplementary Figure from Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC
Supplementary Data from Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC
Supplementary Figure from Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC
Supplementary Data from Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC
<div>AbstractPurpose:<p>Our understanding of the immunopathology resectable non–small cell lung cancer (NSCLC) is still limited. Here, we explore immune programs that inform tumor immunity and response to neoadjuvant chemotherapy chemoimmunotherapy in localized NSCLC.</p>Experimental Design:<p>Targeted gene sequencing using HTG Precision Immuno-Oncology panel was performed NSCLCs from three cohorts based on treatment: naïve (<i>n</i> = 190), 38), 21)....