A5023550975- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Ubiquitin and proteasome pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic and Kidney Cyst Diseases
- Neurological Disease Mechanisms and Treatments
- interferon and immune responses
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Neuroendocrine regulation and behavior
- Circular RNAs in diseases
- Spaceflight effects on biology
- Microtubule and mitosis dynamics
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Magnesium Alloys: Properties and Applications
- Cancer Cells and Metastasis
- Long-Term Effects of COVID-19
- Pain Mechanisms and Treatments
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- NF-κB Signaling Pathways
- ATP Synthase and ATPases Research
Rockefeller University
2016-2025
Hebei Medical University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
University of Alabama at Birmingham
2014-2024
Zhongnan Hospital of Wuhan University
2020-2024
Wuhan University
2020-2024
Tsinghua University
2012-2024
Sixth Affiliated Hospital of Xinjiang Medical University
2023-2024
Xinjiang Medical University
2023-2024
State Key Joint Laboratory of Environment Simulation and Pollution Control
2022-2024
The pseudostratified epithelium of the mouse trachea and human airways contains a population basal cells expressing Trp-63 ( p63 ) cytokeratins 5 Krt5 Krt14 . Using KRT5-CreER T2 transgenic line for lineage tracing, we show that generate differentiated during postnatal growth in adult both steady state epithelial repair. We have fractionated by FACS identified 627 genes preferentially expressed subpopulation vs. non-BCs. Analysis reveals potential mechanisms regulating allows comparison with...
Identifying the cells of origin lung cancer may lead to new therapeutic strategies. Previous work has focused upon putative bronchoalveolar stem cell at bronchioalveolar duct junction as a when codon 12 K-Ras mutant is induced via adenoviral Cre inhalation. In present study, we use two “knock-in” Cre-estrogen receptor alleles inducibly express K-RasG12D in CC10 + epithelial and Sftpc type II alveolar adult mouse lung. Analysis these mice identifies cells, Clara terminal bronchioles, for...
Background SOX2 (Sry-box 2) is required to maintain a variety of stem cells, overexpressed in some solid tumors, and expressed epithelial cells the lung. Methodology/Principal Findings We show that human squamous cell lung tumors adenocarcinomas. have generated mouse models which Sox2 upregulated during development adult. In both cases, overexpression leads extensive hyperplasia. terminal bronchioles, trachea-like pseudostratified epithelium develops with p63-positive underlying columnar...
Sensory organs are composed of neurons, which convert environmental stimuli to electrical signals, and glia-like cells, whose functions not well understood. To decipher glial roles in sensory organs, we ablated the sheath cell major organ Caenorhabditis elegans. We found that glia-ablated animals exhibit profound deficits glia provide activities affect neuronal morphology, behavior generation, uptake lipophilic dyes. understand molecular bases these activities, identified 298 genes messenger...
The intestinal microbiome modulates host susceptibility to enteric pathogens, but the specific protective factors and mechanisms of individual bacterial species are not fully characterized. We show that secreted antigen A (SagA) from Enterococcus faecium is sufficient protect Caenorhabditis elegans against Salmonella pathogenesis by promoting pathogen tolerance. NlpC/p60 peptidoglycan hydrolase activity SagA required generates muramyl-peptide fragments C. in a tol-1-dependent manner. can...
Glia assess axon structure to modulate myelination and repair. Whether glia similarly detect dendrites their substructures is not well understood. Here we show that monitor the integrity of dendrite transiently protect them against perturbations. We demonstrate disruption C. elegans sensory neuron cilia elicits acute glial responses, including increased accumulation glia-derived extracellular matrix around cilia, changes in gene expression, alteration secreted protein repertoire. DGS-1, a...
Glia are essential components of nervous systems. However, genetic programs promoting glia development and regulating glia-neuron interactions have not been extensively explored. Here we describe transcriptional required for function the C. elegans cephalic sheath(CEPsh) glia. We demonstrate ventral- dorsal-restricted roles mls-2/Nkx/Hmx vab-3/Pax6/Pax7 genes,respectively, in CEPsh differentiation expression genes hlh-17/Olig ptr-10/Patched-related. Using mls-2and vab-3 mutants, as well...
The mammalian dynamin-related guanosine triphosphatases Mfn1,2 and Opa1 are required for mitochondrial fusion. However, how their activities controlled coordinated is largely unknown. We present data that implicate the BCL-2–like protein CED-9 in control of fusion Caenorhabditis elegans. demonstrate can promote complete both outer inner membrane. also show this dependent on C. elegans homologue FZO-1 EAT-3. Furthermore, we physically interacts with vivo ability to interact important its...
Neuronal receptive endings, such as dendritic spines and sensory protrusions, are structurally remodeled by experience. How endings acquire their shapes is not well understood. In response to environmental stressors, the nematode Caenorhabditis elegans enters a diapause state, termed dauer, which accompanied remodeling of neuron endings. Here, we demonstrate that AWC neurons in dauers remodel confines compartment defined amphid sheath (AMsh) glial cell envelops these AMsh glia concomitantly...
GABA receptors play an important role in ischemic brain injury. Studies have indicated that autophagy is closely related to neurodegenerative diseases. However, during chronic cerebral hypoperfusion, the changes of hippocampal CA1 area, correlation between and autophagy, their influences on neuronal apoptosis not been well established. Here, we found hypoperfusion resulted rat atrophy, apoptosis, enhancement redistribution down-regulation Bcl-2/Bax ratio, elevation cleaved caspase-3 levels,...
Cell type-specific conditional activation of oncogenic K-Ras is a powerful tool for investigating the cell origin adenocarcinomas in mouse lung. Our previous studies showed that with CC10(Scgb1a1)-CreER driver leads to adenocarcinoma subset alveolar type II cells and hyperplasia bronchioalveolar duct region. However, no tumors develop bronchioles, although recombination occurs throughout this To explore underlying mechanisms, we simultaneously modulated either Notch signaling or Sox2 levels...
Abstract Glutamate is a major excitatory neurotransmitter, and impaired glutamate clearance following synaptic release promotes spillover, inducing extra-synaptic signaling. The effects of spillover on animal behavior its neural correlates are poorly understood. We developed model in Caenorhabditis elegans by inactivating the conserved glial transporter GLT-1. GLT-1 loss drives aberrant repetitive locomotory reversal through uncontrolled oscillatory onto AVA, interneuron governing reversals....
Sensory neurons are an animal's gateway to the world, and their receptive endings, sites of sensory signal transduction, often associated with glia. Although glia known promote sensory-neuron functions, molecular bases these interactions poorly explored. Here, we describe a post-developmental glial role for PROS-1/Prospero/PROX1 homeodomain protein in function C. elegans. Using expression profiling, demonstrate that, unlike previously characterized cell fate roles, PROS-1 functions...