A5020950222- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Malaria Research and Control
- MicroRNA in disease regulation
- Iron Metabolism and Disorders
- Mosquito-borne diseases and control
- Animal Virus Infections Studies
- Hemoglobinopathies and Related Disorders
- Plant Molecular Biology Research
- Research on Leishmaniasis Studies
- Flame retardant materials and properties
- Bone Tissue Engineering Materials
- Oral Health Pathology and Treatment
- Autophagy in Disease and Therapy
- Invertebrate Immune Response Mechanisms
- Neurological Disease Mechanisms and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Polysaccharides and Plant Cell Walls
- Circular RNAs in diseases
- Electrospun Nanofibers in Biomedical Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Compound Pharmacology Studies
- Phase Change Materials Research
- Carbohydrate Chemistry and Synthesis
Tongji University
2012-2025
Stomatological Hospital of Chongqing Medical University
2023-2024
Chongqing Medical University
2023-2024
Beijing University of Chemical Technology
2023
Tongji Hospital
2016-2023
Sichuan University
2015-2023
University of Illinois Chicago
2023
Xinjiang Production and Construction Corps
2023
Tarim University
2023
Shanghai Medical College of Fudan University
2023
MicroRNAs (miRNAs) are studied as key regulators of gene expression involved in different diseases. Several single nucleotide polymorphisms (SNPs) miRNA genes or target sites (miRNA-related SNPs) have been proved to be associated with human diseases by affecting the miRNA-mediated regulatory function. To systematically analyze miRNA-related SNPs and their effects, we performed a genome-wide scan for pre-miRNAs, flanking regions, sites, designed pipeline predict effects them on miRNA-target...
Background Schistosomiasis japonica remains a major public health problem in China. Its pathogen, Schistosoma japonicum has complex life cycle and unique repertoire of genes expressed at different stages. Exploring schistosome gene regulation will yield the best prospects for new drug targets vaccine candidates. MicroRNAs (miRNAs) are highly conserved class noncoding RNA that control many biological processes by sequence-specific inhibition expression. Although large number miRNAs have been...
The aim of this study was to investigate the feasibility and advantages dual delivery bone morphogenetic protein-2 (BMP-2) basic fibroblast growth factor (bFGF) from nano-composite scaffolds (PLGA/PCL/nHA) loaded with vascular stents (PLCL/Col/nHA) for large defect regeneration in rabbit mandibles. Thirty-six defects were repaired rabbits using engineering composed allogeneic marrow mesenchymal stem cells (BMSCs), bFGF, BMP-2 PLGA/PCL/nHA PLCL/Col/nHA. experiments divided into six groups:...
GABA receptors play an important role in ischemic brain injury. Studies have indicated that autophagy is closely related to neurodegenerative diseases. However, during chronic cerebral hypoperfusion, the changes of hippocampal CA1 area, correlation between and autophagy, their influences on neuronal apoptosis not been well established. Here, we found hypoperfusion resulted rat atrophy, apoptosis, enhancement redistribution down-regulation Bcl-2/Bax ratio, elevation cleaved caspase-3 levels,...
Schistosoma japonicum is one of the major causative agents schistosomiasis. The pairing males and females leads to female sexual maturation maintains this mature state. However, mechanisms by which facilitates are yet be investigated. Parasites isolated from single- double-sex cercariae-infected mice were analyzed Solexa uncover pair-regulated miRNA profiles. To reveal biological functions differentially expressed miRNAs among samples, we predicted target genes these compared gene expression...
Parasitic flatworms of the genus Schistosoma are causative agents schistosomiasis, which afflicts more than 200 million people yearly in tropical regions South America, Asia and Africa. A promising approach to control this many other diseases involves application our understanding small non-coding RNA function design safe effective means treatment. In a previous study, we identified five conserved miRNAs from adult stage japonicum. Here, applied Illumina Solexa high-throughput sequencing...
Gambogic acid (GA), the main active component of gamboge resin, has potent antitumor activity both in vivo and vitro. However, underlying molecular mechanisms remain unclear. In this study, we found that GA could initiate autophagy colorectal cancer cells, inhibition process accelerated effect proliferative apoptotic cell death induced by GA, implying a protective role autophagy. Two-dimensional electrophoresis-based proteomics showed treatment altered expression multiple proteins involved...
Sixteen cases of blue nevi were investigated using the anti-melanoma specific antibody HMB-45. This has been found to react with junctional but not intradermal nevus cells, and fetal neonatal, adult, melanocytes. Our study shows that HMB-45 also reacts cells nevus, a unique type nevus. The origin is controversial, results this support hypothesis are purely melanocytic or Schwannian origin, derived from precursor cell some common features both melanocyte Schwann cell.
<title>Abstract</title> Background It is currently established that artemisinin kills malaria parasites by disrupting iron or haem utilization. Similarly, chelators also eliminate these interfering with However, the antimalarial effect of significantly greater than chelators. Understanding differences between two mechanisms beneficial for elucidating action and developing strategies to enhance artemisinin-based combination therapies. Methods We employed single-cell RNA sequencing analysis...
Hemozoin is considered a waste byproduct of heme detoxification following hemoglobin digestion; consequently, the biological functions hemozoin in hemozoin-producing organisms have often been overlooked. However, recent findings indicate that Schistosoma facilitates transfer iron from erythrocytes to eggs through its formation and degradation, thereby increasing interest role malarial hemozoin. Using transmission electron microscopy, we compared malaria Through transcriptome analysis...
PTD4-apoptin protein enters cells and harbors tumor-selective cell death activity. Dacarbazine is the mainstay of treatment for malignant melanoma. In this study, we investigated cytotoxic effect and/or dacarbazine in mouse B16-F1 human A875 SK-MEL-5 melanoma vitro by means a model vivo. inhibits growth B16-F1, dose-dependent manner, but not normal lines WI-38 L-02. combined with revealed synergistic (coefficient drug interaction < 1) all three different tumor lines. vivo, alone effectively...
JOURNAL/nrgr/04.03/01300535-202404000-00034/inline-graphic1/v/2023-09-09T133047Z/r/image-tiff Upregulation of vascular endothelial growth factor A/basic fibroblast (VEGFA/bFGF) expression in the penumbra cerebral ischemia can increase volume, reduce lesion and enhance neural cell proliferation differentiation, thereby exerting neuroprotective effects. However, beneficial effects endogenous VEGFA/bFGF are limited as their is only transiently increased. In this study, we generated multilayered...
Neuritin (Nrn1) is a neurotrophin that plays an important role in nervous system plasticity and repair following nerve injury. MicroRNAs (miRNAs) are type of small non-coding RNA regulate nearly all aspects development survival, including apoptosis. Here it was found miR-204 negatively regulates Nrn1 protein expression through direct interaction with transcript. Moreover, activates cleaved caspase-3, enhancing the sensitivity RSC96 Schwann cells to H2O2-induced oxidative stress Thus,...
Apoptin protein harbors tumor-selective cell death activity, which makes it a potential anticancer therapy candidate. This study reports an apoptin approach based on transduction domain 4 (PTD4)-mediated of recombinant protein. In vitro, the PTD4-apoptin fusion is located in nucleus and induces in, e.g., human hepatocarcinoma HepG2 cells. normal L-02 hepatocytes, retained mainly cytoplasmic did not induce detectable levels death, illustrating that PTD4 does affect apoptin's characteristics....
Mitofusin 2 (Mfn2) is outer membrane protein, as the inhibitor of Ras protein. This study aimed to investigate effect Mfn2 on cell proliferation, and cell-cycle in Hela cervical carcinoma lines.After treated with Adv-mfn2 or Adv-control for 48 h 60 h, RNA protein cells were detected by qRT-PCR western blot. The immunofluorescence assay was performed observe expression sub-location cells. flow cytometry detect cycle cells, while blots Ras-NF-κB signal pathway. Then, xenografted cervix mouse...
To investigate the clinical efficacy of aminovalerate hydrochloride photodynamic therapy (PDT) for oral potentially malignant disorder (OPMD),oral leukoplakia (OLK), along with identifying influencing factors.Additionally, study aims to detect rates recurrence and malignancy after PDT.
Gastric adenocarcinoma (GAC) is a common malignant tumor, accounting for 95% of gastric cancers. However, the effects and regulatory mechanisms long non-coding RNA TRPM2-AS (TRPM2-AS) in GAC have not been fully explored. Our study investigates action mechanism GAC. After performing quantitative Real-Time polymerase chain reaction or western blotting, we found that levels Plasminogen Activator, Urokinase (PLAU) were upregulated GAC, whereas level miR-138-5p was downregulated. Cell function...