A5048403734- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Cytomegalovirus and herpesvirus research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Viral-associated cancers and disorders
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Reproductive tract infections research
- Systemic Lupus Erythematosus Research
- Herpesvirus Infections and Treatments
- Immunotherapy and Immune Responses
- Malaria Research and Control
- Mosquito-borne diseases and control
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Parasites and Host Interactions
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- Hepatitis B Virus Studies
- Cooperative Communication and Network Coding
- Caching and Content Delivery
Wenzhou Medical University
2016-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2021-2024
Yancheng First People's Hospital
2024
Nantong University
2024
Albert Einstein College of Medicine
2013-2023
Fudan University
1999-2021
Center for Cancer Research
2017-2021
National Cancer Institute
2021
Guangzhou Medical University
2015
First Affiliated Hospital of Wenzhou Medical University
2014
Tumor-infiltrating immune cells (TIICs) play essential roles in cancer development and progression. However, the association of TIICs with prognosis colorectal (CRC) patients remain elusive. Infiltration was assessed using ssGSEA CIBERSORT tools. The analyzed 1,802 CRC samples date downloaded from GEO (https://www.ncbi.nlm.nih.gov/geo/) TCGA (https://gdc.cancer.gov/) databases. Three populations TIICs, including CD66b+ tumor-associated neutrophils (TANs), FoxP3+ Tregs, CD163+ macrophages...
Abstract The 5-methylcytosine (m5C) RNA methyltransferase NSUN2 is involved in the regulation of cell proliferation and metastasis formation upregulated multiple cancers. However, biological significance gastric cancer (GC) modification itself have not been fully investigated. Here, we analyzed expression level tissue microarrays containing 403 GC tissues by immunohistochemistry. was GC, that it a predictor poor prognosis. promotes proliferation, migration, invasion cells vitro. We also...
Abstract The induction of cuproptosis, a recently identified form copper‐dependent immunogenic cell death, is promising approach for antitumor therapy. However, sufficient accumulation intracellular copper ions (Cu 2+ ) in tumor cells essential inducing cuproptosis. Herein, an intelligent cuproptosis‐inducing nanosystem constructed by encapsulating oxide (CuO) nanoparticles with the ionophore elesclomol (ES). After uptake cells, ES@CuO degraded to release Cu and ES synergistically trigger...
Abstract Long noncoding RNA s (lnc s), a novel class of transcripts that have critical roles in carcinogenesis and progression, emerged as important gene expression modulators. Recent evidence indicates lnc taurine‐upregulated 1 ( TUG 1) functions an oncogene numerous types human cancers. However, its function the development cervical cancer remains unknown. The aim this research was to investigate clinical significance biological cancer. found be significantly upregulated tissues four cell...
Abstract Background Predictive, preventive, and personalized medicine (PPPM/3PM) is a strategy aimed at improving the prognosis of cancer, programmed cell death (PCD) increasingly recognized as potential target in cancer therapy prognosis. However, PCD-based predictive model for serous ovarian carcinoma (SOC) lacking. In present study, we to establish index (CDI)–based using PCD-related genes. Methods We included 1254 genes from 12 PCD patterns our analysis. Differentially expressed (DEGs)...
Background Schistosomiasis japonica remains a major public health problem in China. Its pathogen, Schistosoma japonicum has complex life cycle and unique repertoire of genes expressed at different stages. Exploring schistosome gene regulation will yield the best prospects for new drug targets vaccine candidates. MicroRNAs (miRNAs) are highly conserved class noncoding RNA that control many biological processes by sequence-specific inhibition expression. Although large number miRNAs have been...
Background: Accumulating evidence suggests that differentially expressed non-coding circular RNAs (circRNAs) play critical roles in the progress of autoimmune diseases. However, role circRNAs systemic lupus erythematosus (SLE) remains unclear. Methods: We initially used next-generation sequencing (NGS) to comprehensively analyze circRNA expression profiles peripheral blood mononuclear cells (PBMCs) from ten SLE patients, stratified by their disease activity characteristics (stable or active...
Our understanding of circulating miRNAs related to systemic lupus erythematosus (SLE) remains very limited. In this study, we screened SLE-specific in plasma from 42 B cell-related by using miRNA PCR Array. The selected were firstly confirmed samples 50 SLE patients, 16 rheumatoid arthritis (RA) patients and 20 healthy donors qRT-PCR. We then investigated the relationship between expressions clinical indicators. As a result, fourteen (miR-103, miR-150, miR-20a, miR-223, miR-27a, miR-15b,...
Epigenetic processes including RNA methylation, post-translational modifications, and noncoding expression have been associated with the heritable risks of systemic lupus erythematosus (Petri et al., 2012). In this study, we aimed to explore dysregulated 5-methylcytosine (m5C) in CD4+ T cells from patients SLE potential function affected mRNAs pathogenesis. mRNA methylation profiles were ascertained through chromatography-coupled triple quadrupole mass spectrometry two pools exhibiting...
Abstract A Plasmodium falciparum chimeric protein 2.9 (PfCP-2.9) was constructed consisting of the C-terminal regions two leading malaria vaccine candidates, domain III apical membrane ag-1 (AMA-1) and 19-kDa fragment merozoite surface 1 (MSP1). The PfCP-2.9 produced by Pichia pastoris in secreted form with a yield 2600 mg/L ∼1 g/L final product obtained from three-step purification process. Analysis conformational properties showed that all six mAbs interacted recombinant were...
Abstract Background The transcriptional regulation of Plasmodium during its complex life cycle requires sequential activation and/or repression different genetic programmes. MicroRNAs (miRNAs) are a highly conserved class non-coding RNAs that important in regulating diverse cellular functions by sequence-specific inhibition gene expression. What is know about double-stranded RNA-mediated silencing (RNAi) and posttranscriptional (PTGS) parasites entice us to speculate whether miRNAs can also...
Parasitic flatworms of the genus Schistosoma are causative agents schistosomiasis, which afflicts more than 200 million people yearly in tropical regions South America, Asia and Africa. A promising approach to control this many other diseases involves application our understanding small non-coding RNA function design safe effective means treatment. In a previous study, we identified five conserved miRNAs from adult stage japonicum. Here, applied Illumina Solexa high-throughput sequencing...
Mouse papillomavirus type 1 (MmuPV1) provides, for the first time, opportunity to study infection and pathogenesis of papillomaviruses in context laboratory mice. In this report, we define transcriptome MmuPV1 genome present papillomas arising experimentally infected mice using a combination RNA-seq, PacBio Iso-seq, 5' RACE, 3' primer-walking RT-PCR, RNase protection, Northern blot situ hybridization analyses. We demonstrate that is transcribed unidirectionally from five major promoters (P)...
Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in head and neck with a complex etiology, such as environmental factors, genetic Epstein-Barr virus infection. The NOP2/Sun domain family, member 2 (NSUN2) methyltransferase m5C methylation modification that has been reported to be involved occurrence progression various tumors, but its role NPC remains unclear. In this study, we found NSUN2 was upregulated predicted poor prognosis for patients both GEO datasets our tissue...
Abstract Abnormal expression and remodeling of cytoskeletal regulatory proteins are important mechanisms for tumor development chemotherapy resistance. This study systematically analyzed the relationship between differential cytoskeleton genes prognosis in gastric cancer (GC). We found Arf GTP-activating protein ASAP1 plays a key role GC patients. Here we level tissue microarrays carrying 564 tissues by immunohistochemistry. The results showed that was upregulated cells can be served as...
Abstract Immunotherapy based on immune checkpoint inhibitors (ICIs) has provided revolutionary results in treating various cancers. However, its efficacy colorectal cancer (CRC), especially microsatellite stability-CRC, is limited. This study aimed to observe the of personalized neoantigen vaccine MSS–CRC patients with recurrence or metastasis after surgery and chemotherapy. Candidate neoantigens were analyzed from whole-exome RNA sequencing tumor tissues. The safety response assessed...
Hepatocellular carcinoma (HCC) is characterized by high vascularity and notable abnormality of blood vessels, where angiogenesis a key process in tumorigenesis metastasis. The main functions Nei Like DNA Glycosylase 3 (NEIL3) include alcoholization repair, immune response regulation, nervous system development function, damage signal transduction. However, the underlying mechanism expression NEIL3 progression HCC whether absence or silencing inhibits cancer remain unclear. Therefore, deeper...
The P. falciparum chimeric protein 2.9 (PfCP-2.9) consisting of the sequences MSP1-19 and AMA-1 (III) is a malaria vaccine candidate that was found to induce inhibitory antibodies in rabbits monkeys. This phase I randomized, single-blind, placebo-controlled, dose-escalation study evaluate safety immunogenicity PfCP-2.9 formulated with novel adjuvant Montanide ISA720. Fifty-two subjects were randomly assigned 4 dose groups 10 participants, each receiving test 20, 50, 100, or 200 microg...