Extraction, purification, structural modification, activities and application of polysaccharides from different parts mulberry were analyzed discussed.

Protein phosphorylation is a major form of post-translational modification (PTM) that regulates diverse cellular processes. In silico methods for site prediction can provide useful and complementary strategy complete phosphoproteome annotation. Here, we present novel bioinformatics tool, PhosphoPredict, combines protein sequence functional features to predict kinase-specific substrates their associated sites 12 human kinases kinase families, including ATM, CDKs, GSK-3, MAPKs, PKA, PKB, PKC,...

The Chinese strong aroma-type liquor ( Baijiu ) fermentation environment is a typical medium-chain fatty acid-producing system with complex nutrients. Although several studies have revealed the correlation between microbial community composition and abiotic factors, adaptation mechanisms of dominant species to are still unknown in this special anaerobic habitat.

Two recently reported bacterial strains that were identified as the dominant caproate-producing bacteria in pit clay, further characterized to determine their phylogeny and taxonomy. The two strains, designated LBM19010T JNU-WLY1368, short rod-shaped, Gram-stain-positive, non-motile strictly anaerobic. Analysis of 16S rRNA gene sequences revealed JNU-WLY1368 shared a sequence similarity 99.93 % belonged recent proposed genus Caproicibacterium family Oscillospiraceae. type strain, LBM19010T,...

Abstract Although it is known that isoflurane exposure or surgery leads to post‐operative cognitive dysfunction in aged rodents, there are few clinical interventions and treatments available prevent this disorder. Minocycline ( MINO ) produces neuroprotection from several neurodegenerative diseases various experimental animal models. Therefore, we set out investigate the effects of pre‐treatment on induced impairment mice by assessing hippocampal‐dependent spatial memory performance using...

Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in head and neck with a complex etiology, such as environmental factors, genetic Epstein-Barr virus infection. The NOP2/Sun domain family, member 2 (NSUN2) methyltransferase m5C methylation modification that has been reported to be involved occurrence progression various tumors, but its role NPC remains unclear. In this study, we found NSUN2 was upregulated predicted poor prognosis for patients both GEO datasets our tissue...

Abstract Gravitational lithosphere removal in continental interior has been inferred from various observations, including anomalous surface deflections and magmatism. We use numerical models a simplified theoretical analysis to investigate how can be recognized the magmatic record. One style of is Rayleigh‐Taylor‐type instability, where occurs through dripping. The associated magmatism depends on thermal structure. Four types are predicted: (1) For relatively hot (e.g., back arcs),...

Postoperative cognitive dysfunction (POCD) has been one of the most common problems in elderly patients following surgery. But specific mechanism POCD is still not clear. To further understand reason these postoperative behavioral deficits, we evaluated spatial learning memory both adult (3 months) and aged (18 male mice, 3 or 28 days after isoflurane (Iso) exposure for two hours appendectomy (App). Hippocampal microglia activation IL-1β, TNF-α, IFN-γ expression were also at day 3, 14 Iso...

Abstract The failure of multi-step experimental procedures to yield diffraction-quality crystals is a major bottleneck in protein structure determination. Accordingly, several bioinformatics methods have been successfully developed and employed select crystallizable proteins. Unfortunately, the majority existing silico only allow prediction crystallization propensity, seldom enabling computational design mutants that can be targeted for enhancing crystallizability. Here, we present Crysalis,...

Caproicibacterium lactatifermentans is a unique and robust caproate-producing bacterium in the family Oscillospiraceae due to its lactate utilization capability, whereas close relatives such as amylolyticum , Caproiciproducens galactitolivorans Caproicibacter fermentans cannot utilize but produce main fermentation end product. Moreover, C. can also several saccharides glucose maltose.

Introduction: Transthyretin protein-related familial amyloidosis polyneuropathy (TTR-FAP) is an autosomal dominant genetic disease caused by mutations in the TTR gene. The characterized primarily peripheral and autonomic nerve damage. Disease progression associated with frequent involvement of heart, lungs, kidneys, eyes, other organs. most common mutation c.148G>A (p.Val50Met), although FAP resulting from rarely involves spinal cord. Patient Concerns: A 68-year-old man was diagnosed...

ABSTRACT Aquatic vegetated habitats are disappearing rapidly, and restoration projects crucial for maintaining their ecological functions. The success of these hinges on the ability to retain sediment, necessitating a comprehensive understanding sediment transport in areas. Therefore, this study builds model based flow turbulent kinetic energy near riverbed predict bedload transport. comprises terms generated by vegetation, which can be further divided into shear term induced velocity...

An anaerobic isolate, designated me31T, was isolated from pit mud in Yibin, Sichuan Province, PR China. Phylogenetic results based on 16S rRNA gene sequence showed that strain me31T belongs to the family Dysgonomonadaceae, and most closely related relatives were Seramator thermalis SYSU GA16112T (93.65%) Proteiniphilum propionicum JNU-WLY501T (93.22%). The DNA G+C content 44.26 mol%. ANI AAI values between strains 69.25-71.18% 69.59-71.15%, respectively. Cells of Gram-stain-negative,...

Cratons, the ancient cores of continental plates, have remained stable for billions years. The high strength cratonic root has long been considered vital its survival in dynamic mantle. However, recent high-resolution seismic studies unveiled widespread velocity discontinuities within middle mantle lithosphere nearly all cratons. These discontinuities, known as mid-lithospheric (MLDs), are characterized by a sharp reduction 2-7% over 10-20 km, primarily at depths 80-120 km. They typically...

Abstract The stability of cratons has long been attributed to their neutral buoyancy and strong roots. However, recent seismic studies have revealed widespread mid‐lithospheric discontinuities (MLDs) within cratonic Previous studies, based on geophysical xenolith evidence, mainly suggest that MLDs are formed through metamorphic processes low strength. This raises the question how most remain stable with weak MLDs. Using numerical models theoretical analysis, we show spatial distribution can...

Phishing attacks are a major threat to online security, exploiting user vulnerabilities steal sensitive information. Various methods have been developed counteract phishing, each with varying levels of accuracy, but they also face notable limitations. In this study, we introduce PhishAgent, multimodal agent that combines wide range tools, integrating both and offline knowledge bases Multimodal Large Language Models (MLLMs). This combination leads broader brand coverage, which enhances...

This paper proposes a lightweight convolutional neural network model to identify the types of natural earthquake and blasting events quickly accurately. Since an event is generally recorded by several stations, it necessary preprocess classify data based on beforehand. ensures that different station waveforms same do not appear in any two training sets, validation test sets. With three-component stations after preprocessing as input, hyperparameters are optimized analyzing average variance...