A5025641802- Peptidase Inhibition and Analysis
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Carbohydrate Chemistry and Synthesis
- Computational Drug Discovery Methods
- Aquatic Ecosystems and Phytoplankton Dynamics
- Click Chemistry and Applications
- Asymmetric Synthesis and Catalysis
- Biochemical and Molecular Research
- Synthesis and Reactions of Organic Compounds
- Synthesis and Catalytic Reactions
- Diabetes Treatment and Management
- Synthesis of heterocyclic compounds
- Silicon Carbide Semiconductor Technologies
- Cancer therapeutics and mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Neuropeptides and Animal Physiology
- Tuberculosis Research and Epidemiology
- Lipoproteins and Cardiovascular Health
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced DC-DC Converters
- HIV/AIDS drug development and treatment
- Plant biochemistry and biosynthesis
- Synthesis of β-Lactam Compounds
- Chronic Lymphocytic Leukemia Research
Army Medical University
2022-2024
Daping Hospital
2022-2024
Jiangxi University of Traditional Chinese Medicine
2022-2024
Xiangnan University
2020-2023
Shanghai Institute of Pharmaceutical Industry
2014-2023
Institute of Hydrobiology
2015-2022
Chinese Academy of Sciences
2015-2022
University of Chinese Academy of Sciences
2015-2022
Jiangnan University
2020-2022
State Key Laboratory of Food Science and Technology
2020
SiC MOSFET devices have great potentials in future high temperature power electronics applications due to their possible higher thermal runaway compared with other semiconductor devices. In this paper, the stability of MOSFETs is investigated by experiments and Saber simulations. The maximum steady-state junction measured exceed 250 °C saber simulations based on experimental model estimate that temperatures are close 300 °C. addition, performance degradation during high-temperature operation...
Background The tumor immune microenvironment (TIME) phenotypes have been reported to mainly impact the efficacy of immunotherapy. Given increasing use immunotherapy in cancers, knowing an individual’s TIME could be helpful screening patients who are more likely respond Our study intended establish, validate, and apply a machine learning model predict profiles non-small cell lung cancer (NSCLC) by using 18 F-FDG PET/CT radiomics clinical characteristics. Methods RNA-seq data 1145 NSCLC from...
To develop and validate a machine learning model using 18F-FDG PET/CT radiomics signature clinical features to predict the presence of micropapillary solid (MP/S) components in lung adenocarcinoma. Eight hundred forty-six patients who underwent preoperative with pathologically confirmed adenocarcinoma were enrolled. After segmentation, 1688 extracted from selected construct predictive models. Then, we developed nomogram based on integrated features. Receiver operating curves, calibration...
This letter presents the design, prototype development, operation, and testing of an 800 kHz, 1 kW, V output boost dc-dc converter module that integrates SiC MOSFET Schottky diode die. It is observed when device loss dominated by switching loss, steady-state junction temperature can reach as high 320°C. highest self-heated operation power devices under room ambient reported in literature. The high-frequency characteristics high-temperature thermal reliability assessed are evaluated detail. A...
The Chinese strong aroma-type liquor ( Baijiu ) fermentation environment is a typical medium-chain fatty acid-producing system with complex nutrients. Although several studies have revealed the correlation between microbial community composition and abiotic factors, adaptation mechanisms of dominant species to are still unknown in this special anaerobic habitat.
In this paper, we report the design, analysis, and simulation of a novel quadrupleband metamaterial absorber at microwave frequencies. The is composed delicate periodic patterned structures metallic background plane, which are separated by dielectric substrate. By manipulating structures, nearly perfect absorption can be obtained four specific resonance Moreover, significantly high absorptions quadruple peaks insensitive to polarization independence, influence incident angle on for both TE...
The secondary injury is more serious after traumatic brain (TBI) compared with primary injury. Release of excessive reactive oxygen species (ROS) and Ca2+ influx at the damaged site trigger Herein, a neutrophil-like cell membrane-functionalized nanoparticle was developed to prevent ROS-associated NCM@MP composed three parts: (1) Differentiated membrane (NCM) synthesized, inflammation-responsive ability achieve effective targeting increase retention time Mn3O4 nimodipine (MP) in deep tissue...
Caproicibacterium lactatifermentans is a unique and robust caproate-producing bacterium in the family Oscillospiraceae due to its lactate utilization capability, whereas close relatives such as amylolyticum , Caproiciproducens galactitolivorans Caproicibacter fermentans cannot utilize but produce main fermentation end product. Moreover, C. can also several saccharides glucose maltose.
Background: Type 2 diabetes (T2D) is a swiftly growing disease which affects human health seriously around the world. So far, nine DPP-4 inhibitors have been launched on markets for patients with T2D. The aminomethyl biaryl derivatives, novel structure scaffold, proved as potential inhibitors. Our team focused modification of derivatives through pharmacophore model. Method: A series were designed according to model, synthesized and evaluated dipeptidyl peptidase 4 (DPP-4) treatment type...
In this paper, reverse characteristics of vertical-channel SiC-JFETs similar to an equivalent diode are discussed and compared with actual SiC-SBD. The relationship between the conduction voltage applied gate-to-source is extracted along channel structure JFETs. Experiments involving operation normally-off in converters then conducted without antiparallel SiC-SBDs at different temperatures. issue JFET mistriggering observed evaluated by introducing extra negative gate bias during switch-off...
Multiple gastrointestinal barriers (mucus clearance and epithelium barrier) are the main challenges in oral administration of nanocarriers. To achieve efficient mucus penetration epithelial absorption, a novel strategy based on mesoporous silica nanoparticles with dendritic superstructure, hydrophilicity, nearly neutral-charged modification was designed. The mPEG covalently grafted (mPEG-DMSNs) had particle size about 200 nm loading capacity up to 50% andrographolide (AG) as nanocrystal...