A5043670132- Ovarian function and disorders
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Systemic Lupus Erythematosus Research
- Lung Cancer Diagnosis and Treatment
- CAR-T cell therapy research
- Medical Imaging Techniques and Applications
- Barrier Structure and Function Studies
- Pancreatitis Pathology and Treatment
- Endometriosis Research and Treatment
- Bladder and Urothelial Cancer Treatments
- Gynecological conditions and treatments
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Retinal Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Microbial Natural Products and Biosynthesis
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Reproductive Biology and Fertility
- Pregnancy-related medical research
- Ferroelectric and Negative Capacitance Devices
China Railway Group (China)
2025
Sun Yat-sen University
2007-2024
Daping Hospital
2021-2024
Army Medical University
2021-2024
Beihang University
2024
Stomatology Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Chongqing Emergency Medical Center
2024
Nanjing Medical University
2020-2023
Abstract Background Chronic lymphocytic leukemia (CLL) results in increased susceptibility to infections. T cell dysfunction is not associated with CLL all patients; therefore, it important identify patients defects. The role of B-cell lymphoma-2 (BCL-2) has been explored; however, few studies have examined its cells patients. Herein, we investigated the regulatory BCL-2 tumor microenvironment. Methods expression was evaluated using flow cytometry. roles were single-cell RNA sequencing...
To develop and validate a machine learning model using 18F-FDG PET/CT radiomics signature clinical features to predict the presence of micropapillary solid (MP/S) components in lung adenocarcinoma. Eight hundred forty-six patients who underwent preoperative with pathologically confirmed adenocarcinoma were enrolled. After segmentation, 1688 extracted from selected construct predictive models. Then, we developed nomogram based on integrated features. Receiver operating curves, calibration...
Traditional magnetic resonance imaging (MRI) contrast agents (CAs) are a type of "always on" system that accelerates proton relaxation regardless their enrichment region. This feature leads to decrease in signal differences between lesions and normal tissues, hampering applications accurate early diagnosis. Herein, we report strategy fabricate glutathione (GSH)-responsive one-dimensional (1-D) manganese oxide nanoparticles (MONPs) with improved T2 relaxivities achieve effective T2/T1...
Abstract RNA interference (RNAi) is a powerful tool for rapidly analyzing gene functions. However, little known about the possible use of dsRNA/siRNA as pest control method. Here, we demonstrate that can induce silence chitin synthase A (CHSA), which an important growth and development cuticles trachea in beet armyworm, Spodoptera exigua . Based on vitro RNAi experiments insect cell line ( Trichoplusia ni High 5), vivo was performed by injecting synthesized into 4th instar larvae S....
To investigate the accuracy of transvaginal three-dimensional hysterosalpingo-contrast sonography using SonoVue (3D SonoVue-HyCoSy) in assessment Fallopian tubal patency.We recruited 75 infertile patients undergoing 3D SonoVue-HyCoSy before standard diagnostic laparoscopy with chromotubation (lap and dye). Tubal patency was assessed by automated coded contrast imaging SonoVue-HyCoSy), findings were compared results lap dye.For detecting among 150 tubes assessed, had a sensitivity 93.5%,...
BACKGROUNDThis study was designed to establish appropriate body mass index (BMI) level for PCOS women and compare metabolic abnormalities between control in Southern China.
The alteration of a watershed's hydrologic response due to urban development, population growth, global warming, and sea level rise have increased the frequency intensity floods. In order cope with new challenges in coastal flood management, many efforts were made after Superstorm Sandy. These call for better understanding hazard, operation infrastructures resilience context, ways mitigate hazard impacts, rebuilding by adaptive design, developing unified scale measuring performance. this...
The sustainable treatment and reuse of waste slurry in shield construction have gained significant attention. This paper explores the application magnetic flocculation technology for treating slurry. CFD-DEM coupling method simulates migration flocs during centrifugation. Two evaluation indexes content floc residue (MCFR) seed recovery rate (MSRR) are introduced. study examines how concentration, feed rate, differential speed affect movement, separation, recovery, proposing directions...
To assess the value of ovarian volume and follicle number in diagnosis polycystic ovary syndrome (PCOS) a Chinese population.This study included 432 women with PCOS selected using National Institutes Health criteria, who were compared 153 age-matched as controls. All participants given transvaginal or transrectal ultrasound scan during day 3-5 menstrual cycle (for regularly menstruating women) randomly oligomenorrheic amenorrheic women). The (calculated simplified formula: 0.5 x length...
Abstract Aims Vascular endothelial growth factor ( VEGF ) and placental PlGF are upregulated in many ocular neovascular diseases such as diabetic retinopathy DR ). KH902 is a recombinant fusion protein with its binding ligand taken from the domains of receptor‐1 VEGFR ‐1) receptor‐2 ‐2) can bind all ‐A isoforms . The aim this study was to investigate underlying mechanisms anti‐angiogenic effects Methods toxic effect on cultured human retinal cells HRECs measured by Annexin V/ PI staining MTT...
Three new phenazine metabolites, strepphenazine A-C (1-3), along with a known compound baraphenazine E 4 were isolated from the culture broth of Streptomyces strain YIM PH20095. The structures elucidated based on spectral data. Compounds 1-4 showed different antifungal activity against Fusarium oxysporum, Plectosphaerella cucumerina, Alternaria panax, and Phoma herbarum, which caused root-rot disease Panax notoginseng minimal inhibitory concentrations (MICs) 16-64 μg/mL; compared 4,...
Oral leukoplakia (OLK) is a common type of potentially malignant disorder. Early identification the malignancy potential leads to better management OLK and prediction development oral squamous cell carcinoma (OSCC). However, there has been no effective biomarker assess risk in OLK. Genomic copy number alteration (CNA) complex chromosomal structural variation genome identified as multiple cancers. This study aimed develop predictive model for transformation by analysis. A total 431 samples...
KH902 is a fusion protein that can bind vascular endothelial growth factor (VEGF) and placental (PlGF) through its binding ligand taken from the domains of VEGF receptor 1 2 (VEGFR2). This study was to investigate effects intravitreal injection on retinas streptozotocin-induced diabetic rats.Two weeks after induction diabetes, left eyes rats in each group received an phosphate-buffered saline (PBS), Avastin or solution, respectively. Four injection, retinal electrophysiological function...
Abstract Anthracyclines are chemotherapeutic drugs used to treat solid and hematologic malignancies. However, life‐threatening cardiotoxicity, with cardiac dilation heart failure, is a drawback. A combination of in vivo for single cell/nucleus RNA sequencing vitro approaches elucidate the underlying mechanism. Genetic depletion pharmacological blocking peptides on phosphatidylinositol binding clathrin assembly (PICALM) evaluate role PICALM doxorubicin‐induced cardiotoxicity vivo. Human...