A5064871412- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- DNA and Nucleic Acid Chemistry
- Luminescence and Fluorescent Materials
- Epigenetics and DNA Methylation
- Molecular Sensors and Ion Detection
- Nonlinear Optical Materials Studies
- Bacteriophages and microbial interactions
- interferon and immune responses
- Organic Electronics and Photovoltaics
- Renal Diseases and Glomerulopathies
- Cancer Cells and Metastasis
- Genetics, Aging, and Longevity in Model Organisms
- Electrochemical sensors and biosensors
- Renal and related cancers
- Circadian rhythm and melatonin
- Acute Lymphoblastic Leukemia research
- Polyomavirus and related diseases
- Photochromic and Fluorescence Chemistry
- Cancer Genomics and Diagnostics
Guangdong Pharmaceutical University
2018-2025
University of Waterloo
2025
Nanjing Medical University
2010-2024
Kunming Institute of Zoology
2016-2024
Nanjing Maternity and Child Health Care Hospital
2023-2024
First Affiliated Hospital of Guangdong Pharmaceutical University
2022-2024
Chinese Academy of Sciences
2016-2024
Jiangsu Province Hospital
2010-2024
China Three Gorges University
2021
Sun Yat-sen University
2008-2019
Triple-negative breast cancer (TNBC) exhibits poor prognosis, with high metastasis and low survival. Long non-coding RNAs (lncRNAs) play critical roles in tumor progression. Here, we identified lncRNA MIR100HG as a pro-oncogene for TNBC Knockdown of decreased cell proliferation induced arrest the G1 phase, whereas overexpression significantly increased proliferation. Furthermore, regulated p27 gene to control cycle, subsequently impacted progression TNBC. In analyzing its underlying...
Increasing evidence shows that long noncoding RNAs (lncRNAs) have important roles in the regulation of multiple cellular processes, including cell division, growth, and apoptosis, as well cancer metastasis neurological disease progression; however, mechanism how lncRNAs regulate these processes is not established. In this study, we demonstrated downregulating expression lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) breast cells inhibited growth induced apoptosis. addition,...
Significance Triple-negative breast cancer (TNBC) is responsible for significant mortality among subtypes, with its treatment largely unsuccessful due to ineffective targeted therapies. Our bioinformatics analysis demonstrates a unique alternative splicing pattern in TNBC compared those of other cancers. In analyzing the underlying mechanism distinct profile, TDP43 , critical gene previously implicated neurodegenerative disease, found promote progression. Mechanistically, regulates extensive...
Abstract RNA interference (RNAi) is a powerful tool for rapidly analyzing gene functions. However, little known about the possible use of dsRNA/siRNA as pest control method. Here, we demonstrate that can induce silence chitin synthase A (CHSA), which an important growth and development cuticles trachea in beet armyworm, Spodoptera exigua . Based on vitro RNAi experiments insect cell line ( Trichoplusia ni High 5), vivo was performed by injecting synthesized into 4th instar larvae S....
A novel colorimetric sensing strategy for biomolecule assay has been developed, which integrates the signal amplification of hybridization chain reaction (HCR) with assembly gold nanoparticles (AuNPs) through triplex formation. In presence targets, HCR process can be triggered, products are specifically recognized by triplex-forming oligonucleotide (TFO) functionalized AuNPs, accompanying aggregation AuNPs and a dramatic absorbance change at 522 nm. addition, DNA hairpin probes form rigid...
Titanium dioxide nanoparticles (n-TiO2) could enhance the bioavailability and toxicity of coexisting organic contaminants in aquatic environment. This study attempted to investigate combined effects n-TiO2 difenoconazole (DIF) on neurodevelopment zebrafish underlying mechanisms. In this study, embryos were exposed (100 μg/L), DIF (0, 0.1 0.5 mg/L) their mixtures from 4 96 h post fertilization (hpf) neurotoxicity was evaluated. Our results indicated that adsorbed into brain significantly...
Early diagnosis of HIV biomarkers or genes is the key to reducing acquired immunodeficiency syndrome (AIDS) mortality. In our work, we developed a novel polymerase chain reaction–dynamic light scattering (PCR-DLS) assay for one-step sensitive detection DNA based on average-diameter change gold nanoparticles (AuNPs). This first PCR that makes use DLS technique as signal read-out, with particle size measured by increasing concentration target DNA. With help AuNP probes, this PCR-DLS can...
Precise evaluation of telomerase activity is highly crucial for early cancer diagnosis. In this study, a sensitive catalytic hairpin assembly-dynamic light scattering (CHA-DLS) assay detection developed by using the diameter change gold nanoparticle (AuNP) probes. The substrate primer can be extended in presence telomerase, producing extension product (TEP) with telomeric repeat units (TTAGGG)n at its 3'-end. TEP specifically trigger CHA process and form tremendous AuNPs-H1/H2...
Abstract Alternative splicing (AS) is a promising clinical target for cancer treatment at the post-transcriptional level. We previously identified unique AS profile in triple-negative breast (TNBC), which regulated by regulator TAR DNA-binding protein-43 (TDP43), thus indicating crucial role of TDP43 heterogeneous TNBC. Cluster differentiation 44 (CD44), widely recognized marker stem cells (BCSCs), extensively spliced into CD44 variant isoforms (CD44v) during development cancer. At present,...
Abstract A series of new star‐shaped donor‐π‐acceptor (D‐π‐A) molecules containing the 2,4,6‐tri(thiophen‐2‐yl)‐1,3,5‐triazine unit were synthesized and characterized. The 1,3,5‐triazine group, as a strong electron‐accepting center, is connected to three electron‐donating end groups through π‐conjugated bridges. As result coexistence electron acceptor donor, these compounds show reversible or quasireversible redox behavior. Through changing peripheral group optical properties can be...
Abstract This work presents an amplified colorimetric biosensor for circulating tumor DNA (ctDNA), which associates the hybridization chain reaction (HCR) amplification with G-Quadruplex DNAzymes activity through triplex formation. In presence of ctDNA, HCR occurs. The resulting products are specially recognized by one sequence to include GGG repeat and other containing three repeats, synergetic effect asymmetrically split forming. Such design takes advantage property high peroxidase-like...
// Ran Cheng 1, * , Ya-Jing Liu 2, Jun-Wei Cui 1 Man Yang Xiao-Ling Peng Li Zhan Wang Li-Zhang Zhu Si-Yi Lu Zou Xiao-Qin Wu Yu-Xia 2 You Zhou Zheng-Yu Fang Wei Department of Breast Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, China Institute Biomedical Research, PKU-HKUST Medical Center, First authors Correspondence to: Wei, email: rxwei1123@163.com Fang, fangzy796@163.com Keywords: aspirin, ER-positive breast cancer, c-myc, cyclinD1, tamoxifen resistance Received:...
Abstract Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. However, underlying molecular mechanism less clear. Here we report that TDP-43, RNA-binding protein, underwent positive selection in mammalian lineage. Furthermore, TDP-43 gene ( Tardbp ) loss induces accumulation large droplets severe deficiency mammary epithelial cells outside alveolar lumens, eventually resulting lactation failure pup starvation within three weeks...
The generation of functional arterial endothelial cells (aECs) from embryonic stem (ESCs) holds great promise for vascular tissue engineering. However, the mechanisms underlying their and potential aECs in revascularizing ischemic are not fully understood. Here, we observed that hypoxia exposure mouse ESCs induced an initial phase HIF1α-mediated upregulation transcription factor Etv2, which turn commitment to EC fate. sustained activation HIF1α these progenitors thereafter NOTCH1 signaling...