A5047453037- Gastric Cancer Management and Outcomes
- Advanced Radiotherapy Techniques
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Immunotherapy and Immune Responses
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Lipids, and Metabolism
- Radiation Therapy and Dosimetry
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Lung Cancer Research Studies
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Breast Cancer Treatment Studies
- MicroRNA in disease regulation
- Bone Tissue Engineering Materials
Tianjin Medical University General Hospital
2016-2025
Army Medical University
2009-2024
Xinqiao Hospital
2014-2024
UPMC Hillman Cancer Center
2006-2024
Weifang People's Hospital
2024
Army Medical College
2024
Tianjin Medical University
2008-2021
First Affiliated Hospital of Jiamusi University
2021
State Council of the People's Republic of China
2019
Southwest Hospital
2009-2016
Ultrasensitive and quantitative fast screening of cancer biomarkers by immunochromatography test strip (ICTS) is still challenging in clinic. The gold nanoparticles (NPs) based ICTS with colorimetric readout enables a quick spectrum but suffers from nonquantitative performance; although fluorescence (FICTS) allows detection, its sensitivity deserves more efforts attentions. In this work, taking advantages FICTS, we described reverse enhancement (rFICTS) bimodal signal for ultrasensitive...
<h3>Importance</h3> Gastric neuroendocrine carcinoma and mixed adenoneuroendocrine are rare pathological types of gastric cancer, there is a lack multicenter studies comparing the prognosis recurrence patterns carcinoma, adenocarcinoma. <h3>Objective</h3> To compare differences in long-term survival among <h3>Design, Setting, Participants</h3> This cohort study included patients with resectable at 23 hospitals China from January 2006 to December 2016. In addition, adenocarcinoma were...
Background Autism spectrum disorder (ASD) is associated with alterations in the gut microbiome. However, there are few studies on microbiota of children ASD China, and a lack consensus changes bacterial species. Purpose Methods We used 16S rRNA sequencing to analyze (2 12 years), HC years). Results Our findings showed that α-diversity, composition, relative abundance group were significantly different from those groups. Compared group, α-diversity was decreased. At genus level,...
The successful implantation depends on the favorable biocompatibility of implant. In this paper,microgrooves surface Ti-6Al-4V titanium alloy implants were made by laser processing technology,scanning electron microscopy and profilometer used to observe textured samples,firstly. Then, liquid-solid contact angle-measuring instrument was characterize wettability samples. Finally,using a microplate reader confocal microscope, cytological behavior cell proliferation, adhesion, differentiation,...
Background: Down-regulation of suppressor cytokine signaling 3 (SOCS3) inhibits prostate cancer (PCa) cell growth. Liver X receptors (LXRs) agonists have been recently introduced for PCa treatment. We postulated that LXR may inhibit the carcinogenesis via SOCS3 pathway. Methods: LNCaP cells were cultured and transfected with small-interfering RNA (SOCS3-siRNA) control (control-siRNA). Then treated activator (GW3965). The expressions related transcript factors, e.g. transcription (STAT3),...
Colorectal cancer (CRC) is the third most lethal and malignant type of in world. Abnormal expression human microRNA-200a (hsa-miRNA-200a or miR-200a) has previously been characterized as a clinically noticeable biomarker several cancers, but its role CRC still unclear. Three miRNA datasets were integratively analyzed by Least Absolute Shrinkage Selector Operation (LASSO) Support Vector Machine-Recursive Feature Elimination (SVM-RFE) algorithms. Nine candidate miRNAs identified validated for...
Abstract Background Curing locally advanced gastric cancer through surgery alone is difficult. Adjuvant and neoadjuvant chemotherapy bring potential benefits to more patients with based on several clinical trials. According phase II studies guidelines, SOX regimen as efficient. However, the optimal duration of has not been established. In this study, we will evaluate efficacy safety different cycles for cancer. Methods RESONANCE-II trial a prospective, multicenter, randomized, controlled III...
Chemoresistance is a major obstacle in the treatment of gastric cancer (GC). Notably, aberrant expression microRNAs (miRs) closely related to tumor development and progression. In present study, role miR-424-5p chemoresistance GC was investigated. Reverse transcription-quantitative PCR used detect levels tissues different cell lines. Cell viability apoptosis were detected via Counting Kit-8 assay, western blotting flow cytometry. The targeting relationship between SMAD-specific E3 ubiquitin...
AIM:To compare intensity-modulated radiotherapy (IMRT) with conformal (CRT) by investigating the dose profiles of primary tumors, electively treated regions, and doses to organs at risk. METHODS:CRT IMRT plans were designed for five patients upper esophageal carcinoma.For each patient, target volumes lesions (67.2 Gy) regions (50.4 predefined.An experienced planner manually one CRT plan.Four generated same dose-volume constraints, but different beam arrangements.Indices including...
Purpose: Cisplatin (DDP) based chemotherapy regimens are widely used in advanced gastric cancer (GC). Drug resistance often limited the clinical benefits of cisplatin regimen. The mechanisms have not been fully revealed. Therefore, further exploration relevant molecular is urgently needed. Patients and methods: DDP associated miRNA GC microarray dataset GSE86195 was obtained from National Center for Biotechnology Information (NCBI) GEO database, GEO2R applied to compare samples two different...
Background There was much hard work to study the trastuzumab resistance in HER2-positive gastric cancer (GC), but information which would reveal this abstruse mechanism is little. In study, we aimed investigate roles of tumor cell-derived CCL2 on and overcome by treatment with anti-CD40-scFv-linked anti-HER2 (CD40 ×HER2) bispecific antibody (bsAb). Methods We measured levels expression GC tissues, revealed biological functions tumor-associated macrophages (TAMs) resistance. Then, developed...
The purpose of this work is to develop an online plan modification technique compensate for the interfractional anatomic changes prostate cancer intensity-modulated radiation therapy (IMRT) treatment based on daily cone beam CT (CBCT) images. In proposed technique, pre-treatment CBCT images are acquired after patient set up couch using in-room laser with guidance setup skin marks. Instead moving rigidly align target or re-planning images, we modify original IMRT account motion and...
Abstract FBXW2 is a poorly characterized F-box protein, as tumor suppressor that inhibits growth and metastasis of lung cancer by promoting ubiquitylation degradation oncogenic proteins, including SKP2 β-catenin. However, what the biological functions in prostate cells whether targets other substrates to involve progression still unclear. Here, we reported overexpression attenuated proliferation PCa models both vitro vivo, while depletion exhibited opposite effects. Intriguingly, was an E3...
Although laparoscopic distal gastrectomy has been widely used for gastric cancer, the best functional reconstruction type not yet established. Based on previous experience, we propose a modified uncut Roux-en-Y anastomosis. This study aimed to compare outcomes of different intracorporeal anastomoses after gastrectomy.From April 2015 August 2020, data 215 patients who underwent was collected. The were divided into 4 groups according digestive tract method, Billroth-I, Billroth-II, Roux-en-Y,...
The purpose of this work is to determine dose delivery errors that could result from systematic rotational setup (DeltaPhi) for prostate cancer patients treated with three-phase sequential boost IMRT. In order implement this, different around three Cartesian axes were simulated five and dosimetric indices, such as dose-volume histogram (DVH), tumour control probability (TCP), normal tissue complication (NTCP) equivalent uniform (EUD), employed evaluate the corresponding influences....