A5100392655- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Metabolomics and Mass Spectrometry Studies
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
- Lipid metabolism and biosynthesis
- Mycobacterium research and diagnosis
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Genetic factors in colorectal cancer
- Prostate Cancer Treatment and Research
- PARP inhibition in cancer therapy
- Fibroblast Growth Factor Research
- Cardiac electrophysiology and arrhythmias
- Bladder and Urothelial Cancer Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- interferon and immune responses
- Adipokines, Inflammation, and Metabolic Diseases
- Mitochondrial Function and Pathology
Tianjin Medical University
2020-2025
Second Hospital of Tianjin Medical University
2020-2025
Twist Bioscience (United States)
2023
Second Hospital of Shandong University
2017-2022
Tianjin Medical University General Hospital
2020-2022
Ludong University
2022
Xiangya Hospital Central South University
2019-2020
Central South University
2019-2020
Changchun University of Chinese Medicine
2020
Lanzhou Jiaotong University
2020
// Tong Liu 1, * , Xin Zhang Shanyu Gao 2 Fangmiao Jing 3 Yongmei Yang 1 Lutao Du Guixi Zheng Peilong Li Chen Chuanxin Wang Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, People’s Republic China Anorectal Surgery, Provincial Traditional Chinese Medical Oncology Center, These authors have contributed equally to this work Correspondence to: Wang, email: cxwang@sdu.edu.cn Keywords: exosome, long noncoding RNA, CRNDE-h, colorectal cancer, biomarker Received:...
Abstract Background Oxaliplatin resistance is a major challenge for treatment of advanced colorectal cancer (CRC). Both acquisition epithelial-mesenchymal transition (EMT) and suppressed drug accumulation in cells contributes to development oxaliplatin resistance. Aberrant expression small noncoding RNA, miR-128-3p, has been shown be key regulator tumorigenesis development. However, its roles the progression CRC oxaliplatin-resistance are largely unknown. Methods Oxaliplatin-resistant normal...
Abstract A major reason for oxaliplatin chemoresistance in colorectal cancer is the acquisition of epithelial–mesenchymal transition (EMT) cells. The long noncoding RNA (lncRNA), MALAT1, a highly conserved nuclear ncRNA and key regulator metastasis development several cancers. However, its role oxaliplatin-induced not well known. In this study, we aim to investigate prognostic therapeutic lncRNA MALAT1 patients receiving oxaliplatin-based therapy further explore potential transcriptional...
Genistein is a natural isoflavone with many health benefits, including antitumour effects. Increased hypoxia-inducible factor 1 α (HIF-1α) levels and glycolysis in tumour cells are associated an increased risk of mortality, cancer progression, resistance to therapy. However, the effect genistein on HIF-1α hepatocellular carcinoma (HCC) still unclear. Cell viability, apoptosis rate, lactate production, glucose uptake were measured HCC cell lines incubation. Lentivirus-expressed transporter...
One major reason for the failure of advanced colorectal cancer (CRC) treatment is occurrence chemoresistance to fluoropyrimidine (FU)-based chemotherapy. Long non-coding RNA HOTAIR has been considered as a pro-oncogene in multiple cancers. However, precise functional mechanism not well known. In this study, we investigated biological and clinical role 5FU resistance CRC. Our results showed that negatively regulated miR-218 expression CRC through an EZH2-targeting miR-218-2 promoter...
Emerging evidences indicate that dysregulated long noncoding RNAs (lncRNAs) are implicated in cancer tumorigenesis and progression might be used as diagnosis prognosis biomarker, or potential therapeutic targets. LncRNA H19 has been reported to upregulated diverse human cancers; however, its clinical significance gastric (GC) remains elusive. Expression levels of 128 pairs GC adjacent normal tissues, cell lines juices compared their corresponding controls were detected by real-time...
Cancer-cell-released exosomal microRNAs (miRNAs) are important mediators of cell-cell communication in the tumor microenvironment. In this study, we sequenced serum exosome miRNAs from esophageal squamous cell carcinoma (ESCC) patients and identified high expression miR-320b to be closely associated with peritumoral lymphangiogenesis lymph node (LN) metastasis. Functionally, could enriched transferred by ESCC-released exosomes directly human lymphatic endothelial cells (HLECs), promoting...
Gastric cancer (GC) is a common malignant with poor prognosis. Ferroptosis has been shown to play crucial roles in GC development. Long non-coding RNAs (lncRNAs) also associated tumor progression GC. This study aimed screen the prognostic ferroptosis-related lncRNAs and construct risk model for GC.Ferroptosis-related from The Cancer Genome Atlas (TCGA) expression data was downloaded. First, single factor Cox proportional hazard regression analysis used select seven TCGA database. And then,...
Colorectal cancer (CRC) is the third most lethal and malignant type of in world. Abnormal expression human microRNA-200a (hsa-miRNA-200a or miR-200a) has previously been characterized as a clinically noticeable biomarker several cancers, but its role CRC still unclear. Three miRNA datasets were integratively analyzed by Least Absolute Shrinkage Selector Operation (LASSO) Support Vector Machine-Recursive Feature Elimination (SVM-RFE) algorithms. Nine candidate miRNAs identified validated for...
Purpose: Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute progression. In our study, we aimed investigate the expression clinical pertinence serine peptidase inhibitor, Kunitz type 1 RNA1 ( SPINT1-AS1 ) CRC. Materials methods: The levels corresponding sense transcript SPINT1 mRNA were analyzed 150 pairs CRC tissues adjacent normal (AN)...
Abstract Accumulating evidence implies that long noncoding RNA s (lnc s) play a crucial role in predicting survival for Hepatocellular carcinoma ( HCC ) patients. This study aims to capture the current research hotspots of , based on analysis publications related from 2013 2017, and identify novel lnc signature prognosis through data mining The Cancer Genome Atlas TCGA ). “Prognosis” “biomarker” were located core hotspot. Moreover, was top one frontier research. associations between outcome...
Background: Colorectal cancer (CRC) represents a third leading cause of cancer-related death worldwide. The reliable diagnostic biomarkers for detecting CRC at early stage is critical decreasing the mortality.Method: A conjunctive lipidomic approach was employed to investigate differences in plasma lipid profiles patients (n = 101) and healthy volunteers 52). Based on UHPLC-Q-TOF MS UHPLC-QQQ platforms, total 236 lipids were structurally detected. Multivariate data analysis conducted...
// Jingjing Li 1 , Kan Chen Fan Wang Weiqi Dai Sainan Jiao Feng Liwei Wu Tong Liu Shizan Xu 1, 2 Yujing Xia Jie Lu Yingqun Zhou Ling 3 and Chuanyong Guo Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School Medicine, 200072, China Clinical Medicine Nanjing Medical University, Tongren 200336, Correspondence to: Xu, email: xiaoling05@126.com Guo, guochuanyong@hotmail.com Keywords: Warburg effect, hexokinase 2, hepatoma, methyl jasmonate, glycolysis...
Accumulating literatures have indicated that long non-coding RNAs (lncRNAs) are crucial molecules in tumor progression various human cancers, including colorectal cancer (CRC). However, the clinical significance and regulatory mechanism of a vast majority lncRNAs CRC remain to be determined. The current study aimed explore function molecular lncRNA AC010789.1 progression. found overexpressed tissues cells. High expression was associated with lymph node metastasis poor prognosis. Moreover,...
Papillary thyroid carcinoma (PTC), the most frequent type of malignant tumor, lacks novel and reliable biomarkers patients' prognosis. In current study, we mined The Cancer Genome Atlas (TCGA) to develop lncRNA signature PTC.The intersection PTC lncRNAs was obtained from TCGA database using integrative computational method. By univariate multivariate Cox analysis, key were identified construct prognostic model. Then, all patients divided into high-risk group low-risk perform Kaplan-Meier...
Preoperative prediction of lymph node (LN) metastasis is accepted as a crucial independent risk factor for treatment decision-making esophageal squamous cell carcinoma (ESCC) patients. Our study aimed to establish non-invasive nomogram identify LN preoperatively in ESCC Construction the involved three sequential phases with patient cohorts. In discovery phase (N = 20), metastasis-associated microRNAs (miRNAs) were selected from next-generation sequencing (NGS) assay human serum exosome...
In clinical practice, few prostate cancer (PCa) patients are associated with metabolic syndrome (MetS), while others acquire MetS during treatment. Whether the treatment of PCa increases occurrence remains to be confirmed. This study reviewed changes in before and after evaluate effects various methods on MetS. We analyzed data 1162 patients, whether or not diagnosed MetS, Data lower urinary tract symptoms, C-reactive protein (CRP), platelet distribution width (PDW), prostate-specific...
EZH2 is overexpressed in bladder cancer (BC) and plays important roles tumor development progression. Recent studies show cell free (cf) RNAs released from cells can reflect tissues changes are stable detectable urine. Although conventional quantitative real-time PCR (qPCR) highly sensitive, low abundances of urinary cf-RNAs usually result false-negatives. Thus, this study develops a nested qPCR (nqPCR) approach to quantify cf-EZH2 mRNA urine further assess its clinical significance for BC....